Elizabeth A Stout

US Patent:

20220226281, Jul 21, 2022

Filed:

May 28, 2020

Appl. No.:

17/614118

Inventors:

- San Diego CA, US
- La Jolla CA, US
Farhana Barmare - San Diego CA, US
Ippei Usui - San Diego CA, US
Venkata Rami Reddy Macherla - San Diego CA, US
Elizabeth Paige Stout - San Diego CA, US
Jacob Neal Beverage - San Diego CA, US
Eduardo Esquenazi - San Diego CA, US
Peter A. Jordan - San Diego CA, US
Phil S. Baran - San Diego CA, US
John R. Teijaro - San Diego CA, US

International Classification:

A61K 31/365
A61K 31/395
A61P 35/00
A61K 45/06

Abstract:

The present disclosure relates to the reversal of T cell exhaustion using aplysiatoxin analogs or PKC theta agonist compounds for anti-cancer immunotherapy. The treatment with aplysiatoxin analogs or PKC theta agonist compounds improve the anti-tumour activity of a T cell, inducing a NFAT-dependent T cell activation, increasing the pool of immune-checkpoint inhibitor responsive T cells, increasing lymphocyte infiltration and increasing the population of activated CD4+ and/or CD8+ cells. The methods of the present disclosure provide treatment of tumors and infections.

US Patent:

20200316214, Oct 8, 2020

Filed:

Jun 18, 2020

Appl. No.:

16/905699

Inventors:

- San Diego CA, US
Venkata Rami Reddy Macherla - San Diego CA, US
Alexander Wayne Schammel - San Diego CA, US
Ippei Usui - San Diego CA, US
Jacob Neal Beverage - San Diego CA, US
Elizabeth Paige Stout - San Diego CA, US
Bryan Junn Lee - San Diego CA, US
Steven Bruce Cohen - San Diego CA, US
Eduardo Esquenazi - La Jolla CA, US

International Classification:

A61K 47/68
C07K 5/02
C07D 277/22
A61P 35/00
C07K 16/28
C07K 16/30

Abstract:

Disclosed herein are compounds, drug-conjugates thereof, methods of preparing drug-conjugates, and uses thereof. Also disclosed are pharmaceutical compositions and methods of treatment. The compounds and drug-conjugates disclosed herein can be used to treat a variety of conditions, diseases and ailments such as bladder cancer, breast cancer, colon cancer, rectal cancer, endometrial cancer, kidney cancer, lung cancer, melanoma, non-Hodgkin lymphoma, glioblastoma, pancreatic cancer, prostate cancer, and thyroid cancer.

US Patent:

20180296688, Oct 18, 2018

Filed:

Sep 27, 2016

Appl. No.:

15/765232

Inventors:

- San Diego CA, US
Venkata Rami Reddy Macherla - San Diego CA, US
Alexander Wayne Schammel - San Diego CA, US
Ippei Usui - San Diego CA, US
Jacob Neal Beverage - San Diego CA, US
Elizabeth Paige Stout - San Diego CA, US
Bryan Junn Lee - San Diego CA, US
Steven Bruce Cohen - San Diego CA, US
Eduardo Esquenazi - La Jolla CA, US

International Classification:

A61K 47/68
C07K 16/28
C07K 16/30
C07K 5/02
A61P 35/00

Abstract:

Disclosed are compounds based on dolastatins, drug-conjugates, methods of preparing drug-conjugates, and uses thereof. Also disclosed are pharmaceutical compositions and methods of treatment. The compounds and drug-conjugates disclosed herein can be used to treat diseases such as bladder cancer, breast cancer, colon cancer, rectal cancer, endometrial cancer, kidney cancer, lung cancer, melanoma, non-Hodgkin lymphoma, glioblastoma, pancreatic cancer, prostate cancer, and thyroid cancer.

US Patent:

20170015710, Jan 19, 2017

Filed:

Mar 3, 2016

Appl. No.:

15/060479

Inventors:

- San Diego CA, US
Alexander Wayne SCHAMMEL - San Diego CA, US
Ippei USUI - San Diego CA, US
Elizabeth Paige STOUT - San Diego CA, US
Jacob Neal BEVERAGE - La Jolla CA, US
Bryan Junn LEE - San Diego CA, US
Steven Bruce COHEN - San Diego CA, US

Assignee:

Sirenas LLC - San Diego CA

International Classification:

C07K 11/02
A61K 38/15
C07K 16/32
A61K 47/48

Abstract:

Provided are cyclic peptide analogs, conjugates comprising such compounds, and pharmaceutical compositions comprising such compounds and conjugates, and methods of treating cancer with such compounds and conjugates.