Feng Liang Miao

US Patent:

20070292857, Dec 20, 2007

Filed:

Aug 8, 2006

Appl. No.:

11/501662

Inventors:

Rama Natarajan - Hacienda Heights CA, US
Feng Miao - Arcadia CA, US

International Classification:

C12Q 1/68

US Classification:

435006000

Abstract:

Many human diseases are now realized to have epigenetic features. Post-translational modification of histones plays a major role in these epigenetic features. Chromatin immunoprecipitation assay (ChIP) is currently the method of choice for localizing histone modifications in a step-wise fashion. This technique utilizes histone modification-specific antibodies to enrich DNA (ChIP DNA), followed by the use of promoter-specific primers to localize the modification. Methods of using DNA microarrays to screen ChIPed DNA are provided herein.

US Patent:

20220313666, Oct 6, 2022

Filed:

Apr 6, 2022

Appl. No.:

17/714569

Inventors:

- Duarte CA, US
Feng Miao - Alhambra CA, US
Nagarajan Vaidehi - Arcadia CA, US
Supriyo Bhattacharya - Monrovia CA, US
Adrien Beau Larsen - Duarte CA, US

International Classification:

A61K 31/437
A61P 3/10
A61K 31/496
A61K 31/4439
A61K 31/5377
A61K 31/4035

Abstract:

Disclosed herein, inter alia, are compounds and methods for inhibiting the thioredoxin-thioredoxin-interacting-protein (TXNIP-TRX) complex.

US Patent:

20200085800, Mar 19, 2020

Filed:

Sep 13, 2019

Appl. No.:

16/570802

Inventors:

- Duarte CA, US
Feng Miao - Alhambra CA, US
Nagarajan Vaidehi - Arcadia CA, US
Supriyo Bhattacharya - Monrovia CA, US
Adrien Beau Larsen - Duarte CA, US

International Classification:

A61K 31/437
A61P 3/10
A61K 31/4035
A61K 31/4439
A61K 31/5377
A61K 31/496

Abstract:

Disclosed herein, inter alia, are compounds and methods for inhibiting the thioredoxin-thioredoxin-interacting-protein (TXNIP-TRX) complex.