Feng Xu

US Patent:

7101912, Sep 5, 2006

Filed:

Dec 8, 2003

Appl. No.:

10/728942

Inventors:

Jia-Ning Xiang - Palo Alto CA, US
Mark A. Gallop - Los Altos CA, US
Kenneth C. Cundy - Redwood City CA, US
Jianhua Li - Sunnyvale CA, US
Feng Xu - Palo Alto CA, US
Cindy X. Zhou - Palo Alto CA, US
Laxminarayan Bhat - Santa Clara CA, US

Assignee:

XenoPort, Inc. - Santa Clara CA

International Classification:

A61K 31/216
C07C 229/28

US Classification:

514533, 514538, 514450, 514452, 514456, 514466, 514469, 514470, 514471, 549229, 549267, 549274, 549436, 549438, 549444, 549304, 549310, 549292, 549313, 558269, 560 34

Abstract:

Prodrugs of carbidopa, derivatives of carbidopa prodrugs, methods of making prodrugs of carbidopa and derivatives thereof, methods of using prodrugs of carbidopa and derivatives thereof, and compositions of prodrugs of carbidopa and derivatives thereof are disclosed.

US Patent:

7220875, May 22, 2007

Filed:

Jan 28, 2004

Appl. No.:

10/766990

Inventors:

Mark A. Gallop - Los Altos CA, US
Feng Xu - Palo Alto CA, US
Kenneth C. Cundy - Redwood City CA, US
Thomas W. Woiwode - San Carlos CA, US

International Classification:

C07C 229/00
A61K 31/385

US Classification:

560 19, 514534

Abstract:

The present invention provides propofol prodrugs, methods of making propofol prodrugs, pharmaceutical compositions of propofol prodrugs and methods of using propofol prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pain and post-chemotherapy or post-operative surgery nausea and vomiting.

US Patent:

7230003, Jun 12, 2007

Filed:

Sep 9, 2004

Appl. No.:

10/958089

Inventors:

Mark A. Gallop - Los Altos CA, US
Feng Xu - Palo Alto CA, US

Assignee:

XenoPort, Inc. - Santa Clara CA

International Classification:

A61K 31/44
A61K 31/235

US Classification:

514277, 546335, 560106, 514345, 514352, 514543, 514544, 514532

Abstract:

Prodrugs of propofol, methods of making prodrugs of propofol, pharmaceutical compositions of prodrugs of propofol and methods of using prodrugs of propofol and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pain and post-chemotherapy or post-operative surgery nausea and vomiting are disclosed herein.

US Patent:

7241807, Jul 10, 2007

Filed:

Jul 12, 2005

Appl. No.:

11/180332

Inventors:

Feng Xu - Palo Alto CA, US
Mark A. Gallop - Los Altos CA, US

Assignee:

XenoPort, Inc. - Santa Clara CA

International Classification:

A61K 31/265

US Classification:

514512, 558248

Abstract:

The present invention provides propofol prodrugs, methods of making propofol prodrugs, pharmaceutical compositions of propofol prodrugs and methods of using propofol prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pain and post-chemotherapy or post-operative surgery nausea and vomiting.

US Patent:

7550506, Jun 23, 2009

Filed:

Jul 12, 2005

Appl. No.:

11/180064

Inventors:

Feng Xu - Palo Alto CA, US
Mark A. Gallop - Los Altos CA, US
Vivek Sasikumar - San Francisco CA, US

Assignee:

XenoPort, Inc. - Santa Clara CA

International Classification:

A61K 31/24
C07C 229/36

US Classification:

514534, 560 19

Abstract:

The present invention provides propofol prodrugs, methods of making propofol prodrugs, pharmaceutical compositions of propofol prodrugs and methods of using propofol prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pain and post-chemotherapy or post-operative surgery nausea and vomiting.

US Patent:

7576127, Aug 18, 2009

Filed:

Aug 21, 2006

Appl. No.:

11/507968

Inventors:

Mark A. Gallop - Los Altos CA, US
Feng Xu - Palo Alto CA, US

Assignee:

XenoPort, Inc. - Santa Clara CA

International Classification:

A61K 31/265
A61K 31/235

US Classification:

514512, 514533, 558273, 560 41

Abstract:

Prodrugs of propofol, methods of making prodrugs of propofol, pharmaceutical compositions of prodrugs of propofol and methods of using prodrugs of propofol and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pain and post-chemotherapy or post-operative surgery nausea and vomiting are disclosed herein.

US Patent:

7585996, Sep 8, 2009

Filed:

Sep 13, 2007

Appl. No.:

11/901194

Inventors:

Mark A. Gallop - Los Altos CA, US
Feng Xu - Palo Alto CA, US
Thu Phan - Fremont CA, US
Usha Dilip - Sunnyvale CA, US
Ge Peng - Mountain View CA, US

Assignee:

XenoPort, Inc. - Santa Clara CA

International Classification:

C07C 271/06
A61K 31/662

US Classification:

560115, 514119

Abstract:

Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of making acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of using acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, and pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs 3-aminopropylphosphinic acid and analogs thereof for treating diseases or disorders such as mild cognitive impairment, cognitive impairment associated with Alzheimer's disease Alzheimer's disease, depression, anxiety, and epilepsy are disclosed. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, which are suitable for oral administration and sustained release oral dosage forms are also disclosed.

US Patent:

7619110, Nov 17, 2009

Filed:

Dec 22, 2005

Appl. No.:

11/317418

Inventors:

Feng Xu - Palo Alto CA, US
Mark A. Gallop - Los Altos CA, US
Vivek Sasikumar - San Francisco CA, US
Usha Dilip - Sunnyvale CA, US

Assignee:

XenoPort, Inc. - Santa Clara CA

International Classification:

C07C 229/06

US Classification:

560 46, 514 19, 514171, 514295, 514299, 514397, 558276

Abstract:

The present invention provides a prodrug of propofol and crystalline forms thereof, methods of making the propofol prodrug and crystalline forms thereof, pharmaceutical compositions of the propofol prodrug and crystalline forms thereof, methods of using the propofol prodrug and crystalline forms thereof and pharmaceutical compositions thereof to treat diseases or disorders such as headache pain, post-chemotherapy or post-operative surgery nausea and vomiting, neurodegenerative disorders, and mood disorders.