Feng Xu

US Patent:

7009055, Mar 7, 2006

Filed:

Jul 19, 2002

Appl. No.:

10/484610

Inventors:

Feng Xu - Staten Island NY, US
Kimberly A. Savary - Rahway NJ, US
John M. Williams - Hillsborough NJ, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07D 215/16

US Classification:

546177, 546180, 568 34, 568 28

Abstract:

A dibromomethyl moiety is converted to a sulfonylmethyl moiety by treatment with a sulfinic acid salt. For example, (methyl-sulfonyl)methyl bromo-quinoline is prepared by the treatment of dibromomethyl bromo-quinoline with a sulfinic acid salt.

US Patent:

7339054, Mar 4, 2008

Filed:

Feb 6, 2004

Appl. No.:

10/544575

Inventors:

Feng Xu - Staten Island NY, US
Matthew M Bio - London, GB
Cameron Cowden - Hoddesdon, GB
Kimberly A. Petrillo - Philadelphia PA, US
J. Michael Williams - Hillsborough NJ, US
Chunhua Yang - Edison NJ, US
Marjorie See Waters - Cranbury NJ, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C07H 19/14
C07D 487/00

US Classification:

536 2711, 536 272, 544262

Abstract:

A process is provided for the preparation of branched-chain ribonucleosides of formula (I):.

US Patent:

7902376, Mar 8, 2011

Filed:

Jan 22, 2009

Appl. No.:

12/321533

Inventors:

Feng Xu - Staten Island NY, US
Mary M. Kim - Cheltenham PA, US
Yoshinori Kohmura - Ibaraki, JP
Tricia Sladicka - Schenectady NY, US
Jonathan D. Rosen - Iowa City IA, US
Michael J. Zacuto - Jersey City NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ
Banyu Pharmaceutical Co., Ltd. - Tokyo

International Classification:

C07D 498/04
C07D 487/04
C07D 309/10

US Classification:

548218, 548242, 5483605, 549419

Abstract:

A novel process is provided for the preparation of chiral trans-2,3-disubstituted 5-oxotetrahydropyrans of structural formula (I):.

US Patent:

8022084, Sep 20, 2011

Filed:

Jan 26, 2006

Appl. No.:

11/813796

Inventors:

Daniel J. Kumke - Rahway NJ, US
Jerry A. Murry - Rahway NJ, US
Bryon L. Simmons - Rahway NJ, US
Feng Xu - Rahway NJ, US

Assignee:

H. Lundbeck A/S - Valby

International Classification:

A61K 31/4355
C07D 498/04

US Classification:

514302, 546116

Abstract:

The present invention is directed to novel polymorphic forms of the compound 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrate (gaboxadol monohydrate). The invention is further concerned with pharmaceutical compositions containing the polymorphic forms as an active ingredient, methods for treatment of disorders susceptible to amelioration by GABAA receptor agonism with the polymorphic forms, and processes for the preparation of the polymorphic forms.

US Patent:

20170233382, Aug 17, 2017

Filed:

Aug 10, 2015

Appl. No.:

15/503035

Inventors:

Steven P. MILLER - Rahway NJ, US
Carmela MOLINARO - Rahway NJ, US
David THAISRIVONGS - Rahway NJ, US
Feng XU - Rahway NJ, US
Richard DESMOND - Rahway, US
Hongming LI - Rahway NJ, US
Qinghao CHEN - Rahway NJ, US
Andrew STAMFORD - Rahway NJ, US
Zhiguo Jake SONG - Rahway NJ, US
Lushi TAN - Rahway NJ, US
- Rahway NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 417/12
C07C 313/06
C07C 311/33
C07D 213/81

Abstract:

This invention provides processes for the preparation of verubecestat (Compound of Formula (I)), a potent inhibitor of BACE-1 and BACE-2. In addition, the invention provides certain synthetic intermediates which are useful, among other things, for the preparation of the Compound of Formula (I).

US Patent:

20160251375, Sep 1, 2016

Filed:

Oct 14, 2014

Appl. No.:

15/029876

Inventors:

Feng XU - Rahway NJ, US
Richard DESMOND - Rahway NJ, US
Guy R. HUMPHREY - Rahway NJ, US
Hongming LI - Rahway NJ, US
Ji QI - East Chang An, Beijing, CN
Rebecca T. RUCK - Rahway NJ, US
Zhiguo Jake SONG - Rahway NJ, US
Tao WANG - Berkeley Heights NJ, US
Yong-Li ZHONG - Rahway NJ, US
Jeonghan PARK - Whippany NJ, US
Laura Marie ARTINO - Rahway NJ, US
Richard John VARSOLONA - Rahway NJ, US
- Rahway NJ, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C07D 498/16
C07C 231/12
C07C 45/00
C07C 45/63
C07C 271/34
C07C 29/58
C07C 269/04
C07D 403/12
C07K 5/12
C07C 29/36
C07C 27/20

Abstract:

The present invention includes compounds useful as intermediates in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing macrolactams. One use of the methods and intermediates described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. HCV NS3 inhibitory compounds have therapeutic and research applications.

US Patent:

20140200343, Jul 17, 2014

Filed:

Aug 16, 2012

Appl. No.:

14/239393

Inventors:

Feng Xu - Staten Island NY, US
Guy Humphrey - Hillsborough NJ, US
Tao Pei - Morganville NJ, US
Zhiguo Jake Song - Edison NJ, US
Tao Wang - Berkeley Heights NJ, US
Laura Artino - Oakhurst NJ, US

International Classification:

C07D 498/16
C07D 403/12

US Classification:

540457, 544354

Abstract:

The present invention includes compounds useful as intermediates in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing macrolactams from the intermediates. One use of the methods and intermediates described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. HCV NS3 inhibitory compounds have therapeutic and research applications.