The present disclosure concerns methods for recombinantly producing functional ataxia-telangiectasia (ATM) protein, methods for isolating recombinant functional ATM protein, and uses of ATM protein. In particular, a method is disclosed for using a vaccinia virus vector to express ATM, and using immunoprecipitation or affinity tagging to isolate recombinant ATM.
Richard Gatti - Sherman Oaks CA, US Anthony Butch - Pacific Palisades CA, US Helen Chun - Woodland Hills CA, US Xia Sun - Beijing, CN
International Classification:
G01N033/574 G01N033/53 G01N033/537 G01N033/543
US Classification:
435/007230, 435/007920
Abstract:
The present disclosure concerns methods for recombinantly producing functional ataxia-telangiectasia (ATM) protein, methods for isolating recombinant functional ATM protein, and uses of ATM protein including diagnosing a patient for A-T and/or susceptibility to various conditions including cancer, particularly breast cancer, neurological disorders, and heart disease. Specifically, a method is disclosed for determining the amount of ATM protein in a patient's cells, comparing that amount to a reference, and forming a diagnosis.
Name / Title
Company / Classification
Phones & Addresses
Helen Y. Chun
Chatham Investments, LLC Investment Company · Investor
1901 Ave Of The Stars, Los Angeles, CA 90067 23 Chatham, Manhattan Beach, CA 90266 26 Chatham, Manhattan Beach, CA 90266
Helen Chun Owner
Gabriel Dental Ceramics Dental Ceramics
3829 Foothill Blvd, Glendale, CA 91214 (818)9570504
Jeongsang Language School Dongtan, KR Mar 2012 to Feb 2013 English Language InstructorWagner Elementary School Placentia, CA Oct 2011 to Dec 2011 Student TeacherInland Presbyterian Church Pomona, CA Aug 2010 to Aug 2011 Children DirectorInland Vacation Bible School Pomona, CA Jun 2005 to Jun 2011 Event CoordinatorDr. Albert Schweitzer Elementary School Magnolia, CA Sep 2010 to Oct 2010 Student TeacherInland Presbyterian Church Pomona, CA Sep 2004 to Sep 2010 Sunday School Bible Study TeacherInland Presbyterian Summer School Pomona, CA Jun 2008 to Jun 2010 TeacherOak Ridge Elementary School Chino Hills, CA Sep 2009 to Nov 2009 Classroom Volunteer
Education:
California State University, Fullerton Fullerton, CA 2010 to 2011 Multiple Subject Teaching Credential, SB 2042California State University Fullerton, CA 2006 to 2010 Bachelors of Arts in Liberal Studies