Emma R. Parmee - Scotch Plains NJ, US Yusheng Xiong - Plainsboro NJ, US Jian Guo - Scotch Plains NJ, US Rui Liang - East Brunswick NJ, US Linda Brockunier - Orange NJ, US
Assignee:
Merck & Co., Inc - Rahway NJ
International Classification:
A61K 31/416 C07D 231/02
US Classification:
514406, 5483771, 5483644
Abstract:
Pyrazoles having a naphthyl group attached are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
Substituted Pyrazoles, Compositions Containing Such Compounds And Methods Of Use
Linda Brockunier - Orange NJ, US Jian Guo - Scotch Plains NJ, US Rui Liang - East Brunswick NJ, US Emma R. Parmee - Scotch Plains NJ, US Subharekha Raghavan - Teaneck NJ, US George Scott Tria - Princeton NJ, US Yusheng Xiong - Plainsboro NJ, US
The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.
Pyrazole Derivatives, Compositions Containing Such Compounds And Methods Of Use
Emma R. Parmee - Scotch Plains NJ, US Yusheng Xiong - Plainsboro NJ, US Jian Guo - Scotch Plains NJ, US Rui Liang - East Brunswick NJ, US Linda Brockunier - Orange NJ, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
A61K 31/415 A61K 31/4162 C07D 231/10
US Classification:
514406, 5483771, 544350, 514249
Abstract:
Pyrazoles having a naphthyl group attached are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
Sanyog Pendharkar - Old Bridge NJ, US Jian Guo - Bridgewater NJ, US
International Classification:
A61F015/00 B32B027/12
US Classification:
424/445000, 442/123000
Abstract:
The present invention is directed to a hemostatic wound dressing that utilizes a fibrous, fabric substrate made from a biocompatible polymer and containing a first wound-contacting surface and a second surface opposing the first surface, the fabric having flexibility, strength and porosity effective for use as a hemostat; and further having a porous, polymeric matrix distributed at least on the first surface and through the fabric, the porous, polymeric matrix being made of a biodegradable biocompatible, water-soluble or water-swellable aldehyde-oxidized polysaccharide.
Pyrazole Derivatives, Compositions Containing Such Compounds And Methods Of Use
Emma Parmee - Scotch Plains NJ, US Yusheng Xiong - Plainsboro NJ, US Jian Guo - Scotch Plains NJ, US Linda Brockunier - Orange NJ, US
International Classification:
A61K 31/415 C07D 231/12
US Classification:
514406000, 548377100
Abstract:
Pyrazoles having a naphthyl group attached are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.
Linda L. Brockunier - Orange NJ, US Jian Guo - Scotch Plains NJ, US Emma R. Parmee - Scotch Plains NJ, US Subharekha Raghavan - Teaneck NJ, US Keith Rosauer - Laurence Harbor NJ, US Darby Schmidt - Arlington MA, US John E. Stelmach - Westfield NJ, US
Compounds of Formula I are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of the Formula I, to their use for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of the Formula I.
Subharekha Raghavan - Teaneck NJ, US John E. Stelmach - Westfield NJ, US Cameron J. Smith - Lawrenceville NJ, US Hong Li - Edison NJ, US Alan Whitehead - Scotch Plains NJ, US Sherman T. Waddell - Westfield NJ, US Yi-Heng Chen - Whippany NJ, US Shouwu Miao - Edison NJ, US Olga A. Ornoski - Teaneck NJ, US Joie Garfunkle - Metuchen NJ, US Xibin Liao - Edison NJ, US Jiang Chang - Westfield NJ, US Xiaoqing Han - Edison NJ, US Jian Guo - Scotch Plains NJ, US Jonathan A. Groeper - Metuchen NJ, US Linda L. Brockunier - Orange NJ, US Keith Rosauer - New Hampton IA, US Emma R. Parmee - Doylestown PA, US
A compound of Formula (I): or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula I, or a pharmaceutically acceptable salt thereof, for their use in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical preparations which comprise compounds of Formula (I) or a pharmaceutically acceptable salt thereof.
Systems And Methods For Detecting Wireless Charger Coupling
- Cupertino CA, US Guangwu Duan - Cupertino CA, US Jian Guo - Palo Alto CA, US Chaitanya Mudivarthi - Sunnyvale CA, US Long T. Pham - San Jose CA, US
International Classification:
H02J 50/90 H02J 50/10
Abstract:
Circuitry in the electronic device may use a plurality of magnetic sensors to detect an alternating current signal transmitted by the wireless charger and/or to detect a magnetic field generated by one or more magnets in the wireless charger. The circuitry may determine a position of the wireless charger relative to a wireless power transfer coil in the electronic device and provide feedback to guide users in attaching the wireless charger to the correct position on the electronic device, including such as visual indications on a device display.
Deepx Asset Management
Founder and Chief Executive Officer
Fenghe Asset Management Sep 2015 - Oct 2016
Chief Research Officer
Tenxor Technology Oct 1, 2014 - Jun 2016
Chief Executive Officer and Co-Founder at Tenxor Technology, Inc
Harvard University May 1, 2011 - Jul 2014
Assistant Professor
University of Michigan Sep 2006 - Apr 2011
Ph.d Student
Education:
University of Michigan 1989 - 2011
Doctorates, Doctor of Philosophy, Advertising, Mining, Statistics
Tsinghua University 1999 - 2003
Bachelors, Bachelor of Science, Mathematics, Applied Mathematics
Beijing No. 2 High School
Skills:
Research Computer Science Entrepreneurship Start Ups Internet Research Online Advertising Mobile Internet Social Media Social Networking Search Data Mining Information Retrieval Statistics Big Data R Machine Learning
Interests:
New Technology Michigan Entrepreneurship Boston Yahoo Labs Hong Kong Machine Learning Venture Capital Silicon Valley Ann Arbor Harvard University Computational Advertising Augmented Reality Web 2 Beijing Mobile Internet
Languages:
Mandarin English
Senior Manager Business Intelligence And Data Analytics Architecture
Stryker
Senior Manager Business Intelligence and Data Analytics Architecture
Jpmorgan Chase & Co. Aug 2013 - Feb 2016
Lead Architect and Vice President
Goldman Sachs Jun 2011 - Jul 2013
Solution Architect - Financial Risk Technology
Goldman Sachs Sep 2006 - May 2011
Senior System Engineer - Enterprise Technology
Goldman Sachs Jul 2001 - Aug 2006
System Analyst - Securities Division
Education:
New York University May 2010
Master of Business Administration, Masters
Nyu Stern School of Business 2007 - 2010
Master of Business Administration, Masters
Drexel University Jun 2001
Master of Science, Masters
University of Pennsylvania 1999 - 2001
Master of Science, Masters
Beijing Institute of Technology Oct 1998
Master of Science, Masters
Drexel University 1996 - 1998
Masters, Mechanical Engineering
Beijing Institute of Technology Jun 1996
Bachelors, Bachelor of Science
Beijing Institute of Technology 1992 - 1996
Bachelors, Mechanical Engineering
Skills:
It Strategy Enterprise Architecture Solution Architecture Trading Systems Business Analysis Sdlc Software Development Strategy Fixed Income Risk Management Sybase Equities Requirements Analysis Market Data Big Data Derivatives Software Project Management Systems Management Business Intelligence Virtualization Low Latency Cloud Computing It Infrastructure Management Bloomberg Financial Modeling Technical Architecture Valuation
OmniVision - Santa Clara, CA since Sep 2011
Analog Design Engineer
Tufts University Sep 2006 - Sep 2011
PhD Candidate
Texas Instruments Feb 2010 - Aug 2010
Characterization Engineer
GE May 2008 - Aug 2008
Embedded System Engineer
Shanghai Jiao Tong University Jun 2004 - Oct 2005
Research Assistant
Education:
Tufts University 2006 - 2011
PhD, Analog & Mixed-Signal IC design, A/D Converters
Tufts University 2006 - 2009
Master in Electrical Engineering, Analog and Mixed-Signal IC design
Shanghai Jiao Tong University 2002 - 2006
B.S., Electrical Engineering
They alleged that, between August 2023 and mid-February this year, she repeatedly passed information to Jian Guo a German national who was an aide to far-right European Parliament lawmaker Maximilian Krah and was arrested in April. That, prosecutors said, included above all information on the tran