Jian N Xu

US Patent:

6073017, Jun 6, 2000

Filed:

May 29, 1997

Appl. No.:

8/864927

Inventors:

Jian Ming Xu - Plano TX
Patrick N. Sollee - Richardson TX
Adam E. T. Bryant - Oxfordshire, GB

Assignee:

Nortel Networks Corporation - Montreal

International Classification:

H04Q 720

US Classification:

455435

Abstract:

A system and method for increasing capacity of a cellular system by reducing call overhead processing and transmission congestion previously required in updating a subscriber's mobile station data position as the subscriber moves among locations within a geographic area served by a network service provider is presented. A predetermined N number of copies of mobile station subscriber data is distributed among multiple Visiting Location Registers (VLRs) within the area served by a cellular system. Unlike previous systems, when mobile stations traverse location boundaries, the current VLR corresponding to the current location does not need to update the subscriber data if that data has not changed since the subscriber was last in that location.

US Patent:

60919523, Jul 18, 2000

Filed:

May 29, 1997

Appl. No.:

8/864926

Inventors:

Jian Ming Xu - Plano TX
Patrick N. Sollee - Richardson TX
Adam E. T. Bryant - Benson, GB

Assignee:

Nortel Networks Corporation - Montreal

International Classification:

H04Q 720

US Classification:

455433

Abstract:

A system and method for increasing capacity of a cellular system by reducing call overhead processing and transmission congestion previously required in updating a subscriber's mobile station data position as the subscriber moves among locations within a geographic area served by a network service provider is presented. A predetermined N number of copies of mobile station subscriber data is distributed among multiple Visiting Location Registers (VLRs) within the area served by a cellular system. Unlike previous systems, when mobile stations traverse location boundaries, the current VLR corresponding to the current location does not need to update the subscriber data if that data has not changed since the subscriber was last in that location.

US Patent:

20200087651, Mar 19, 2020

Filed:

Sep 17, 2019

Appl. No.:

16/573389

Inventors:

- Boston MA, US
Daniel E. Bauer - Cambridge MA, US
Jian Xu - Plano TX, US

Assignee:

The Children's Medical Center Corporation - Boston MA

International Classification:

C12N 15/01
C07K 14/47
C07K 14/805
C12N 15/10
C12N 15/63
A61K 35/12
A61K 38/46
C12N 9/22

Abstract:

Provided herein are methods and compositions for increasing fetal hemoglobin levels in a cell by disrupting BCL11A expression at the genomic level. Also provided herein are methods and compositions relating to the treatment of hemoglobinopathies by reinduction of fetal hemoglobin levels.

US Patent:

20190062736, Feb 28, 2019

Filed:

Aug 22, 2018

Appl. No.:

16/108307

Inventors:

- Austin TX, US
Jian Xu - Plano TX, US

International Classification:

C12N 15/11
C12N 15/113

Abstract:

The present invention includes a method for detecting or isolating one or more specific genomic target regions and molecules interacting therewith comprising: contacting a recombinant nuclease-deficient Cas9 fusion protein (dCas9) modified to comprise a biotinylation sequence and one or more sequence-specific guide RNAs, with one or more specific genomic DNA targets in cells to form a CRISPR complex; and detecting or isolating the CRISPR complex with a streptavidin or an avidin to detect or isolate the one or more specific genomic target regions and molecules in the CRISPR complex.

US Patent:

20180119130, May 3, 2018

Filed:

Nov 17, 2017

Appl. No.:

15/816083

Inventors:

- Boston MA, US
Daniel E. Bauer - Cambridge MA, US
Jian Xu - Plano TX, US

Assignee:

The Children's Medical Center Corporation - Boston MA

International Classification:

C12N 15/01
C07K 14/47
C12N 15/10
A61K 35/12
A61K 38/46
C12N 15/63
C07K 14/805
C12N 9/22

Abstract:

Provided herein are methods and compositions for increasing fetal hemoglobin levels in a cell by disrupting BCL11A expression at the genomic level. Also provided herein are methods and compositions relating to the treatment of hemoglobinopathies by reinduction of fetal hemoglobin levels.

US Patent:

20150307867, Oct 29, 2015

Filed:

Nov 27, 2013

Appl. No.:

14/647547

Inventors:

- Boston MA, US
Daniel E. BAUER - Cambridge MA, US
Jian XU - Plano TX, US

Assignee:

CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA

International Classification:

C12N 15/01
A61K 38/46
A61K 35/12
C12N 9/22

Abstract:

Provided herein are methods and compositions for increasing fetal hemoglobin levels in a cell by disrupting BCL11A expression at the genomic level. Also provided herein are methods and compositions relating to the treatment of hemoglobinopathies by reinduction of fetal hemoglobin levels.