John M Lyle

US Patent:

58639225, Jan 26, 1999

Filed:

Jul 7, 1997

Appl. No.:

8/889041

Inventors:

David J. Mayer - Richmond VA
Donald D. Price - Richmond VA
Jianren Mao - Richmond VA
John W. Lyle - Belmar NJ

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

A61K 31505
A61K 31445
A61K 31165

US Classification:

514270

Abstract:

The analgesic effectiveness of a combination drug containing at least one analgesic is significantly enhanced by the addition of a nontoxic N-methyl-D-aspartate (NMDA) receptor antagonist thereto.

US Patent:

53210123, Jun 14, 1994

Filed:

Apr 6, 1993

Appl. No.:

8/043280

Inventors:

David J. Mayer - Richmond VA
Donald D. Price - Richmond VA
Jianren Mao - Richmond VA
John W. Lyle - Belmar NJ

Assignee:

Virginia Commonwealth University Medical College - Richmond VA

International Classification:

A61K 3170
A61K 3155
A61K 3154
A61K 3144

US Classification:

514 25

Abstract:

Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e. g. , a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA receptor activation, e. g. , a ganglioside such as GM. sub. 1 or GT. sub. 1b, a phenothiazine such as trifluoperazine or a naphthalenesulfonamide such as N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, inhibit the development of tolerance to and/or dependence on addictive drugs, e. g. , narcotic analgesics such as morphine, codeine, etc.

US Patent:

55568386, Sep 17, 1996

Filed:

May 19, 1994

Appl. No.:

8/245970

Inventors:

David J. Mayer - Richmond VA
Donald D. Price - Richmond VA
Jianren Mao - Richmond VA
John W. Lyle - Belmar NJ

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

A61K 3170
A61K 3154
A61K 3144
A61K 31445

US Classification:

514 25

Abstract:

Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e. g. , a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA-receptor activation, e. g. , a ganglioside such as GM. sub. 1 or GT. sub. 1b, a phenothiazine such as trifluoperazine or a naphthalenesulfonamide such as N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, inhibit the development of tolerance to and/or dependence on addictive drugs, e. g. , narcotic analgesics such as morphine, codeine, etc.

US Patent:

53526830, Oct 4, 1994

Filed:

Mar 5, 1993

Appl. No.:

8/027177

Inventors:

David J. Mayer - Richmond VA
Donald D. Price - Richmond VA
Jianren Mao - Richmond VA
John W. Lyle - Belmar NJ

Assignee:

Virginia Commonwealth University Medical College of Virginia - Richmond VA

International Classification:

A61K 31485

US Classification:

514289

Abstract:

Chronic pain is alleviated in a mammal suffering therefrom by administering to the mammal a chronic pain alleviating amount of a nontoxic N-methyl-D-aspartate receptor antagonist such as dextromethorphan, dextrorphan, ketamine or pharmaceutically acceptable salt thereof, alone or in combination with a local anesthetic and optionally in sustained release dosage form.

US Patent:

58344799, Nov 10, 1998

Filed:

Nov 6, 1996

Appl. No.:

8/746202

Inventors:

David J. Mayer - Richmond VA
Donald D. Price - Richmond VA
Jianren Mao - Richmond VA
John W. Lyle - Belmar NJ

International Classification:

A61K 31485

US Classification:

514289

Abstract:

The analgesic effectiveness of an NSAID is significantly enhanced by administering the NSAID prior to, with or following the administration of an analgesia enhancer which is a nontoxic NMDA receptor blocker and/or a nontoxic substance that blocks at least one major intracellular consequence of NMDA receptor activation.

US Patent:

58694986, Feb 9, 1999

Filed:

Jul 7, 1997

Appl. No.:

8/888728

Inventors:

David J. Mayer - Richmond VA
Donald D. Price - Richmond VA
Jianren Mao - Richmond VA
John W. Lyle - Belmar NJ

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

A61K 31445
A61K 3119

US Classification:

514282

Abstract:

The analgesic effectiveness of a combination drug containing at least one analgesic is significantly enhanced by the addition of a nontoxic N-methyl-D-aspartate (NMDA) receptor antagonist thereto.

US Patent:

58407316, Nov 24, 1998

Filed:

Aug 2, 1995

Appl. No.:

8/510546

Inventors:

David J. Mayer - Richmond VA
Donald D. Price - Richmond VA
Jianren Mao - Richmond VA
John W. Lyle - Belmar NJ

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

A61K 3116
A61K 3144

US Classification:

514289

Abstract:

The analgesic effectiveness of a combination drug composition containing at least one analgesic is significantly enhanced by the addition of a nontoxic N-methyl-D-aspartate (NMDA) receptor antagonist thereto.

US Patent:

56542810, Aug 5, 1997

Filed:

Apr 26, 1995

Appl. No.:

8/429114

Inventors:

David J. Mayer - Richmond VA
Donald D. Price - Richmond VA
Jianren Mao - Richmond VA
John W. Lyle - Belmar NJ

Assignee:

Virginia Commonwealth University - Richmond VA

International Classification:

A61K 3170
A61K 3155
A61K 3154
A61K 31535
A61K 3144
A61K 31445

US Classification:

514 25

Abstract:

Nontoxic substances that block the N-methyl-D-aspartate (NMDA) receptor, e. g. , a morphinan such as dextromethorphan or dextrorphan, or that block a major intracellular consequence of NMDA receptor activation, e. g. , a ganglioside such as GM. sub. 1 or GT. sub. 1b, a phenothiazine such as trifluoperazine or a naphthalenesulfonamide such as N-(6-aminohexyl) -5-chloro-1-naphthalenesulfonamide, inhibit the development of tolerance to and/or dependence on addictive drugs, e. g. , narcotic analgesics such as morphine, codeine, etc.