Joshua H Weinstein

US Patent:

20130196861, Aug 1, 2013

Filed:

May 6, 2011

Appl. No.:

13/696375

Inventors:

The Board of Trustees of the Leland Stanford Junior Univeristy - Palo Alto CA, US
Joshua Weinstein - Stanford CA, US
Ning Jiang - Stanford CA, US
Daniel S. Fisher - Los Altos CA, US

Assignee:

THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY - Palo Alto CA

International Classification:

C12Q 1/68
G06F 19/18

US Classification:

506 2, 702 19

Abstract:

A precise measurement of the immunological receptor diversity present in a sample is obtained by sequence analysis. Samples of interest are generally complex, comprising more than 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10or more different sequences for a receptor of interest. Immunological receptors of interest include immunoglobulins, T cell antigen receptors, and major histocompatibility receptors. The specific composition of immunological receptor sequence variations in the sample can be recorded and output. The composition is useful for predictive, diagnostic and therapeutic methods relating to the immune capabilities and history of an individual. Such predictions and diagnoses are used to guide clinical decisions.

US Patent:

20210366572, Nov 25, 2021

Filed:

Feb 23, 2021

Appl. No.:

17/182817

Inventors:

- Cambridge MA, US
Joshua Asher Weinstein - Cambridge MA, US
Patrick Hsu - Cambridge MA, US

Assignee:

The Broad Institute, Inc. - Cambridge MA
Massachusetts Institute of Technology - Cambridge MA
President and Fellows of Harvard College - Cambridge MA

International Classification:

G16B 20/30
G16B 20/00
C12N 15/10
C12N 9/22
C12N 15/113

Abstract:

Disclosed are thermodynamic and multiplication methods concerning CRISPR-Cas systems, and apparatus therefor.

US Patent:

20210054461, Feb 25, 2021

Filed:

Sep 1, 2020

Appl. No.:

17/009386

Inventors:

- Stanford CA, US
Joshua Weinstein - Stanford CA, US
Ning Jiang - Austin TX, US
Daniel S. Fisher - Los Altos CA, US

International Classification:

C12Q 1/6883

Abstract:

High-throughput long read sequencing is used to perform immunogenomic characterization of expressed antibody repertoires in the context of vaccination. Informatic analysis allows global characterizations of isotype distributions, determination of the lineage structure of the repertoire and measure age and antigen related mutational activity. Global analysis of the immune system's clonal structure provides direct insight into the effects of vaccination and provides a detailed molecular portrait of age-related effects.

US Patent:

20210002722, Jan 7, 2021

Filed:

Jul 16, 2020

Appl. No.:

16/931102

Inventors:

- Stanford CA, US
Joshua Weinstein - Stanford CA, US
Ning Jiang - Austin TX, US
Daniel S. Fisher - Los Altos CA, US

International Classification:

C12Q 1/6876
G16B 20/00
G16B 30/00
C12Q 1/6883
C12Q 1/6809
C12Q 1/6886

Abstract:

A precise measurement of the immunological receptor diversity present in a sample is obtained by sequence analysis. Samples of interest are generally complex, comprising more than 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10or more different sequences for a receptor of interest. Immunological receptors of interest include immunoglobulins, T cell antigen receptors, and major histocompatibility receptors. The specific composition of immunological receptor sequence variations in the sample can be recorded and output. The composition is useful for predictive, diagnostic and therapeutic methods relating to the immune capabilities and history of an individual. Such predictions and diagnoses are used to guide clinical decisions.

US Patent:

20190024171, Jan 24, 2019

Filed:

Aug 31, 2018

Appl. No.:

16/119602

Inventors:

- Stanford CA, US
Joshua Weinstein - Stanford CA, US
Ning Jiang - Austin TX, US
Daniel S. Fisher - Los Altos CA, US

International Classification:

C12Q 1/6876
C12Q 1/6809
C12Q 1/6883
C12Q 1/6886
G06F 19/22
G06F 19/18
C12Q 1/6874
C40B 50/06

Abstract:

A precise measurement of the immunological receptor diversity present in a sample is obtained by sequence analysis. Samples of interest are generally complex, comprising more than 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10or more different sequences for a receptor of interest. Immunological receptors of interest include immunoglobulins, T cell antigen receptors, and major histocompatibility receptors. The specific composition of immunological receptor sequence variations in the sample can be recorded and output. The composition is useful for predictive, diagnostic and therapeutic methods relating to the immune capabilities and history of an individual. Such predictions and diagnoses are used to guide clinical decisions.

US Patent:

20180363059, Dec 20, 2018

Filed:

Jun 21, 2018

Appl. No.:

16/014900

Inventors:

- Stanford CA, US
Joshua Weinstein - Stanford CA, US
Ning Jiang - Austin TX, US
Daniel S. Fisher - Los Altos CA, US

International Classification:

C12Q 1/6883

Abstract:

High-throughput long read sequencing is used to perform immunogenomic characterization of expressed antibody repertoires in the context of vaccination. Informatic analysis allows global characterizations of isotype distributions, determination of the lineage structure of the repertoire and measure age and antigen related mutational activity. Global analysis of the immune system's clonal structure provides direct insight into the effects of vaccination and provides a detailed molecular portrait of age-related effects.

US Patent:

20180127827, May 10, 2018

Filed:

Dec 20, 2017

Appl. No.:

15/848715

Inventors:

- Stanford CA, US
Joshua Weinstein - Stanford CA, US
Ning Jiang - Austin TX, US
Daniel S. Fisher - Los Altos CA, US

International Classification:

C12Q 1/6883

Abstract:

High-throughput long read sequencing is used to perform immunogenomic characterization of expressed antibody repertoires in the context of vaccination. Informatic analysis allows global characterizations of isotype distributions, determination of the lineage structure of the repertoire and measure age and antigen related mutational activity. Global analysis of the immune system's clonal structure provides direct insight into the effects of vaccination and provides a detailed molecular portrait of age-related effects.

US Patent:

20160333405, Nov 17, 2016

Filed:

Feb 10, 2016

Appl. No.:

15/040887

Inventors:

- Stanford CA, US
Joshua Weinstein - Stanford CA, US
Ning Jiang - Austin TX, US
Daniel S. Fisher - Los Altos CA, US

International Classification:

C12Q 1/68

Abstract:

A precise measurement of the immunological receptor diversity present in a sample is obtained by sequence analysis. Samples of interest are generally complex, comprising more than 10, 10, 10, 10, 10, 10, 10, 10, 10, 10, 10or more different sequences for a receptor of interest. Immunological receptors of interest include immunoglobulins, T cell antigen receptors, and major histocompatibility receptors. The specific composition of immunological receptor sequence variations in the sample can be recorded and output. The composition is useful for predictive, diagnostic and therapeutic methods relating to the immune capabilities and history of an individual. Such predictions and diagnoses are used to guide clinical decisions.