Kelly S Kraft

US Patent:

7279597, Oct 9, 2007

Filed:

Nov 6, 2000

Appl. No.:

10/111144

Inventors:

Kelly Kraft - Hopewell Junction NY, US
Maria A. P. Boyd - Garrison NY, US

Assignee:

Emisphere Technologies, Inc. - Tarrytown NY

International Classification:

C07C 229/28
A61K 31/19

US Classification:

562455, 562458, 514570, 514571

Abstract:

Phenyl amine carboxylic acid compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.

US Patent:

7297794, Nov 20, 2007

Filed:

Nov 13, 2002

Appl. No.:

10/495797

Inventors:

David Gschneidner - Thornwood NY, US
Kelly Kraft - Hopewell Junction NY, US
Chen Zhu - Berkeley Heights NJ, US
Yi Chen - Cheshire CT, US

Assignee:

Emisphere Technologies, Inc. - Tarrytown NY

International Classification:

C07D 295/03
C07D 233/58
C07C 215/46
A61K 31/535
A61K 31/415
A61K 31/135

US Classification:

544174, 5483411, 564353, 5142392, 514399, 514651

Abstract:

Phenoxy amine compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.

US Patent:

7951971, May 31, 2011

Filed:

Jun 13, 2008

Appl. No.:

12/139276

Inventors:

Kelly Kraft - Hopewell Junction NY, US
Maria Aurora P. Boyd - Garrison NY, US
Puchun Liu - Chappaqua NY, US
Pingwah Tang - Elmsford NY, US
Jun Liao - Yorktown Heights NY, US
John Smart - Katonah NY, US

Assignee:

Emisphere Technologies, Inc. - Cedar Knolls NJ

International Classification:

C07C 65/30

US Classification:

562459

Abstract:

Phenoxy carboxylic acid compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.

US Patent:

8227409, Jul 24, 2012

Filed:

Jun 11, 2010

Appl. No.:

12/813839

Inventors:

Kelly S. Kraft - Poughquag NY, US
Karla Somerville - Corona CA, US

Assignee:

MannKind Corporation - Valencia CA

International Classification:

A61K 47/22
A61K 38/02
A61K 38/22
A61K 38/28
A61K 38/29
A61K 38/26
A61K 38/23
C07D 241/08
A61P 3/10

US Classification:

514 59, 514 11, 514 117, 514 118, 514 119, 514 69, 514 72, 514784, 514 97, 544385

Abstract:

Disclosed herein are fumaryl diketopiperazine (FDKP) compositions and microparticles having a specific trans isomer content of about 45% to about 65%. The FDKP microparticles can comprise a drug such as an endocrine hormone, including, peptide, including, insulin, glucagon, parathyroid hormones and the like and can be used to make a powder formulation for pulmonary delivery of the drug.

US Patent:

8314106, Nov 20, 2012

Filed:

Dec 29, 2009

Appl. No.:

12/649210

Inventors:

Kelly Sullivan Kraft - Hopewell Junction NY, US

Assignee:

MannKind Corporation - Valencia CA

International Classification:

A61K 31/4965
C07D 241/00

US Classification:

51425502, 544385

Abstract:

Disclosed are drug delivery systems for the delivery of small molecule and macromolecular drugs. More particularly, disclosed are substituted analogs of 3,6-di(alkyl-4 aminobutyl)-2,5-diketopiperazine (which may also be referred to DKP), their use in the formulation of both small molecule and macromolecular drugs including therapeutic, prophylactic and diagnostic agents, stabilizing agents and systems for their delivery.

US Patent:

8410309, Apr 2, 2013

Filed:

Jul 18, 2006

Appl. No.:

11/458331

Inventors:

Kelly Kraft - Hopewell Junction NY, US
David Gschneidner - Thornwood NY, US
Maria Aurora P. Boyd - Garrison NY, US
Puchun Liu - Chappaqua NY, US
Pingwah Tang - Elmsford NY, US
Jun Liao - Yorktown Heights NY, US
John Smart - Katonah NY, US

Assignee:

Emisphere Technologies, Inc. - Roseland NJ

International Classification:

C07C 59/90
C07C 62/32
C07C 65/40

US Classification:

562471, 562433, 562459, 562465, 562493

Abstract:

Phenoxy carboxylic acid compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.

US Patent:

20130053309, Feb 28, 2013

Filed:

Oct 11, 2012

Appl. No.:

13/649430

Inventors:

Kelly Sullivan Kraft - Hopewell Junction NY, US

International Classification:

A61K 38/28
A61P 3/10

US Classification:

514 65

Abstract:

Disclosed are drug delivery systems for the delivery of small molecule and macromolecular drugs. More particularly, disclosed are substituted analogs of 3,6-di(alkyl-4 aminobutyl)-2,5-diketopiperazine (which may also be referred to DKP), their use in the formulation of both small molecule and macromolecular drugs including therapeutic, prophylactic and diagnostic agents, stabilizing agents and systems for their delivery.

US Patent:

20130289278, Oct 31, 2013

Filed:

Mar 15, 2013

Appl. No.:

13/834106

Inventors:

Kelly Sullivan Kraft - Poughquag NY, US
John J. Freeman - New Fairfield CT, US
Paul Serwinski - Bristol CT, US
Vinnie Pavia - Valencia CA, US
Otto Phanstiel, IV - Oviedo FL, US
Navneet Kaur - Danbury CT, US

Assignee:

MANNKIND CORP - Valencia CA

International Classification:

C07D 241/08
C07C 67/39
C07C 201/12

US Classification:

544385, 560 20, 560204

Abstract:

Disclosed embodiments relate to improved methods for the synthesis of activated fumarate intermediates and their use in chemical synthesis. Disclosed embodiments describe the synthesis of activated fumarate esters including those derived from activating groups including: 4-nitrophenyl, diphenylphosphoryl azide, pivaloyl chloride, chlorosulfonyl isocyanate, p-nitrophenol, MEF, trifluoroacetyl and chlorine, for example, ethyl fumaroyl chloride and the subsequent use of the activated ester in situ. Further embodiments describe the improved synthesis of substituted aminoalkyl-diketopiperazines from unisolated and unpurified intermediates allowing for improved yields and reactor throughput.