- Experience in the multiple-step synthe... • amino acid analysis and mass spectrometr... • circular dichroism • FTIR and NMR spectroscopy - Experience i... • ready-to-use • lyo cake and topical formulation develop... • cGMP synthesis of API and drug products ... • purification as well as structure elucid... • blood samples and skin biopsies - Knowle... • GPC-MALLS • DLS • LC-MS • HPLC • ion-exchange chromatography and size-exc... • drawing • image-editing • page-layout and graphing programs on a v... • PC • Sun • and Silicon Graphics
Us Patents
2,4-Pentadienoic Acid Derivatives Having Selective Activity For Retinoid X (Rxr) Receptors
Compounds having the formulas below, where R is H, lower alkyl, or a pharmaceutically acceptable salt, and where R represents i-propyl, t-butyl or n-butyl groups, have selective RXR retionoid agonist activity.
[3-(C5-14Alkyl-2-Oxo-1,2,3,4-Tetrahydro-Quinolin-6-Yl)-3-Oxo-Propenyl]-Phenyl And [3-(C5-14Alkyl-2-Oxo-1,2,3,4- Tetrahydro-Quinolin-6-Yl)-3-Oxo-Propenyl]-Heteroaryl Derivatives Having Anti-Tumor Activity
Richard L. Beard - Newport Beach CA, US Tien T. Duong - Irvine CA, US Janet A. Takeuchi - Anaheim CA, US Ling Li - Irvine CA, US Kwok Yin Tsang - Irvine CA, US Xiaoxia Liu - Tustin CA, US Jayasree Vasudevan - Anaheim CA, US Liming Wang - Irvine CA, US Santosh C. Sinha - Irvine CA, US Haiqing Yuan - Irvine CA, US Roshantha A. Chandraratna - Laguna Hills CA, US
Assignee:
Allergan, Inc. - Irvine CA
International Classification:
A61K031/35 A61K031/235 A61K031/19
US Classification:
514456, 514532, 514569, 560 56, 562466
Abstract:
Compounds of the formula where the variations have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effects of transiently increasing triglyceride levels and reducing serum thyroxine levels.
5-[Phenyl-Tetrahydronaphthalene-2-Yl Dihydronaphthalen-2-Yl And Heteroaryl-Cyclopropyl]-Pentadienoic Acid Derivatives Having Serum Glucose Reducing Activity
Jayasree Vasudevan - Anaheim CA, US Liming Wang - Irvine CA, US Xiaoxia Liu - Tustin CA, US Kwok Yin Tsang - Irvine CA, US Ling Li - Irvine CA, US Janet A. Takeuchi - Anaheim CA, US Thong Vu - Garden Grove CA, US Richard Beard - Newport Beach CA, US Smita Bhat - Irvine CA, US Vidyasagar Vuligonda - Irvine CA, US Roshantha A. Chandraratna - Laguna Hills CA, US
Assignee:
Allergan, Inc. - Irvine CA
International Classification:
A61K 31/135 C07C 62/00 C07C 69/52 C07C 211/16
US Classification:
514654, 562500, 564384
Abstract:
Compounds of formulas 1 through 17 provided in the specification specifically or selectively inhibit either the cytochrome P450RAI-1 enzyme or the cytochrome P450RAI-2 enzyme.
Disubstituted Chalcone Oximes Having Rarγ Retinoid Receptor Antagonist Activity
Kwok Yin Tsang - Irvine CA, US Santosh Sinha - Irvine CA, US Xiaoxia Liu - Tustin CA, US Smita Bhat - Irvine CA, US Roshantha A. Chandraratna - Laguna Hills CA, US
Assignee:
Allergan, Inc. - Irvine CA
International Classification:
C07C 249/00 C07D 211/08 C07D 335/04
US Classification:
564265, 546192, 546 26, 549 23, 564253
Abstract:
Compounds of the formula.
Disubstituted Chalcone Oximes Having Rarγ Retinoid Receptor Antagonist Activity
Kwok Yin Tsang - Irvine CA, US Santosh Sinha - Irvine CA, US Xiaoxia Liu - Tustin CA, US Smita Bhat - Irvine CA, US Roshantha A. Chandraratna - Laguna Hills CA, US
Assignee:
Allergan, Inc. - Irvine CA
International Classification:
C07C 205/00 C07C 229/00 C07C 249/00
US Classification:
560 21, 560 20, 560 19, 562440, 562442, 562451
Abstract:
Compounds of the formula.
Disubstituted Chalcone Oximes As Selective Agonists Of Rar Retinoid Receptors
Kwok Yin Tsang - Irvine CA, US Santosh Sinha - Ladera Ranch CA, US Xiaoxia Liu - Lake Forest CA, US Smita Bhat - Irvine CA, US Roshantha A. Chandraratna - Laguna Hills CA, US
2009 to 2000 Associate DirectorNURX PHARMACEUTICAL Irvine, CA 2008 to 2009 Principal Research ScientistSPECTRUM PHARMACEUTICAL Irvine, CA 2007 to 2008 Chemical Process Development Manager/Senior Research ScientistVITAE PHARMACEUTICAL Irvine, CA 2004 to 2006 Senior Research ScientistALLERGAN INC Irvine, CA 1997 to 2004 Principal Research Scientist / Retinoid ResearchMASSACHUSETTS INSTITUTE OF TECHNOLOGY Cambridge, MA 1995 to 1997 Postdoctoral Associate / Chemistry DepartmentTEXASA&MUNIVERSITY College Station, TX 1990 to 1994 Graduate Research Assistant / Chemistry DepartmentTEXASA&MUNIVERSITY
1990 to 1994 Teaching Assistant / Chemistry DepartmentKwok Yin Hong Kong, Hong Kong Island 1989 to 1990 Research Assistant / Chemistry Department
Education:
Texas A&M University College Station, TX 1990 to 1994 PhD in ChemistryHong Kong Baptist College Hong, MO 1986 to 1989 BS in Chemistry
Skills:
- Experience in the multiple-step synthesis of small organic compounds and polymerization using various modern synthetic techniques - Experience in structure-based molecular modeling - Experience in oligonucleotide synthesis - Experience in the parallel synthesis of peptides utilizing various solid phase methodologies; HF cleavage of peptides; peptide purification and identification by HPLC, amino acid analysis and mass spectrometry (MALDI and Plasma Desorption mass spectrometry); structural analysis and characterization employing UV-Vis spectroscopy, circular dichroism, FTIR and NMR spectroscopy - Experience in oral, ready-to-use, lyo cake and topical formulation development - Experience in managing/coordinating chemical process development, cGMP synthesis of API and drug products and their stability study in CROs and CMOs - Experience in separation, purification as well as structure elucidation of trace impurities derived from the API process chemistry - Experience in developing and executing analytical methods for active pharmaceutical ingredients (API) analysis in various formulations, blood samples and skin biopsies - Knowledge of and experience in the techniques involved in peptide and protein crystallization as well as various chromatography techniques including GC,GPC-MALLS, DLS,LC-MS, HPLC, ion-exchange chromatography and size-exclusion chromatography - Experience in interacting with patent attorneys for various patent issues in US and foreign countries. Broad experience in NCE patent preparation and prosecution - Experience in the use of various word processing, drawing, image-editing, page-layout and graphing programs on a variety of platforms including MAC, PC, Sun, and Silicon Graphics
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