The present invention provides αβintegrin ligands that display high binding affinity, specificity, and stability. The ligands comprise a peptide having n independently selected amino acids, wherein at least one amino acid is an unnatural amino acid or a D-amino acid, and wherein n is an integer of from 3 to 20. Methods are provided for administering the ligands for treating cancer, inflammatory diseases, and autoimmune diseases. Also provided are methods for administering the ligands for imaging a tumor, organ, or tissue in a subject.
Methods And Compositions For Detecting And Treating Cea-Expressing Cancers
Bret Sellman - Gaithersburg MD, US Christine Tkaczyk - Gaithersburg MD, US Lei Hua - Gaithersburg MD, US Partha Chowdhury - Gaithersburg MD, US Reena Varkey - Gaithersburg MD, US Melissa Damschroder - Gaithersburg MD, US Li Peng - Gaithersburg MD, US Vaheh Oganesyan - Gaithersburg MD, US Jamese Johnson Hilliard - Gaithersburg MD, US
Assignee:
MEDIMMUNE, LLC - Gaithersburg MD
International Classification:
C07K 16/12
US Classification:
4241651, 5303895, 435184
Abstract:
Herein provided are compositions, methods of manufacture and methods of use pertaining to anti-alpha toxin antibodies and fragments.
- San Francisco CA, US Michelle Ma - San Mateo CA, US Aniket Patil - Milpitas CA, US Li Peng - Oakland CA, US
International Classification:
G01C 21/34
Abstract:
Techniques are provided for determining and updating locations in databases for providing to transport user devices to facilitate picking up (retrieving) an item and delivery. Location points (e.g., for retrieval or delivery) can be measured by transporter devices when an item is retrieved, and a central value can be determined from the measured location points. The central value can be used to update a pin location in a database for a destination, e.g., when more paths by the transport user devices cross a boundary (geofence) around then central value than a boundary around an existing pin location.
Combination Therapies Using Anti-Pseudomonas Psl And Pcrv Binding Molecules
- Cambridge, GB Paul WARRENER - Gaithersburg MD, US Charles STOVER - Gaithersburg MD, US Bret SELLMAN - Gaithersburg MD, US Ralph MINTER - Cambrige, GB Sandrine GUILLARD - Cambridge, GB Steven RUST - Cambridge, GB Mladen TOMICH - Exton PA, US Vignesh VENKATRAMAN - Cambridge, GB Reena VARKEY - Gaithersburg MD, US Li PENG - Gaithersburg MD, US Melissa DAMSCHRODER - Gaithersburg MD, US Partha S. CHOWDHURY - Gaithersburg MD, US Nazzareno DIMASI - Gaithersburg MD, US Ryan FLEMING - Gaithersburg MD, US Binyam BEZABEH - Gaithersburg MD, US Changshou GAO - Gaithersburg MD, US Godfrey RAINEY - Gaithersburg MD, US Cuihua GAO - Gaithersburg MD, US
International Classification:
C07K 16/12
Abstract:
This disclosure relates to combination therapies comprising anti-Psl and PcrV binding molecules and related compositions, for use in prevention and treatment of infection.
Combination Therapies Using Anti-Pseudomonas Psl And Pcrv Binding Molecules
- CAMBRIDGE, GB Paul WARRENER - Gaithersburg MD, US Charles STOVER - Gaithersburg MD, US Bret SELLMAN - Gaithersburg MD, US Ralph MINTER - Cambridge, GB Sandrine GUILLARD - Cambridge, GB Steven RUST - Cambridge, GB Mladen TOMICH - Exton PA, US Vignesh VENKATRAMAN - Cambridge, GB Reena VARKEY - Gaithersburg MD, US Li PENG - Gaithersburg MD, US Melissa DAMSCHRODER - Gaithersburg MD, US Partha S. CHOWDHURY - Gaithersburg MD, US Nazzareno DIMASI - Gaithersburg MD, US Ryan FLEMING - Gaithersburg MD, US Binyam BEZABEH - Gaithersburg MD, US Changshou GAO - Gaithersburg MD, US Godfrey RAINEY - Gaithersburg MD, US Cuihua GAO - Gaithersburg MD, US
International Classification:
C07K 16/12
Abstract:
This disclosure relates to combination therapies comprising anti-Psl and PcrV binding molecules and related compositions, for use in prevention and treatment of infection.
Multi-Specific Anti-Pseudomonas Psl And Pcrv Binding Molecules And Uses Thereof
- GAITHERSBURG MD, US - CAMBRIDGE, GB Charles STOVER - Gaithersburg MD, US Bret SELLMAN - Gaithersburg MD, US Ralph MINTER - Cambridge, UK Sandrine GUILLARD - Cambridge, UK Steven RUST - Cambridge, UK Mladen TOMICH - Exton PA, US Vignesh VENKATRAMAN - Cambridge, UK Reena VARKEY - Gaithersburg MD, US Li PENG - Gaithersburg MD, US Melissa DAMSCHRODER - Gaithersburg MD, US Partha CHOWDHURY - Gaithersburg MD, US Nazzareno DIMASI - Gaithersburg MD, US Ryan FLEMING - Gaithersburg MD, US Binyam BEZABEH - Gaithersburg MD, US Changshou GAO - Gaithersburg MD, US Godfrey RAINEY - Gaithersburg MD, US Cuihua GAO - Gaithersburg MD, US
International Classification:
C07K 16/12 A61K 45/06 A61K 39/40
Abstract:
This disclosure relates to combination therapies comprising anti-Psl and PcrV bispecific binding molecules and related compositions, for use in prevention and treatment of infection.
Combination Therapies Using Anti-Pseudomonas Psl And Pcrv Binding Molecules
- Gaithersburg MD, US - Cambridge, GB Charles Stover - Gaithersburg MD, US Bret Sellman - Gaithersburg MD, US Ralph Minter - Cambridge, GB Sandrine Guillard - Cambridge, GB Steven Rust - Cambridge, GB Mladen Tomich - Exton PA, US Vignesh Venkatraman - Cambridge, GB Reena Varkey - Gaithersburg MD, US Li Peng - Gaithersburg MD, US Melissa Damschroder - Gaithersburg MD, US Partha Chowdhury - Gaithersburg MD, US Nazzareno Dimasi - Gaithersburg MD, US Ryan Fleming - Gaithersburg MD, US Binyam Bezabeh - Gaithersburg MD, US Changshou Gao - Gaithersburg MD, US
International Classification:
C07K 16/12 A61K 39/40 A61K 45/06
Abstract:
The disclosure relates to combination therapies comprising anti-Psl and PcrV binding molecules and related compositions, for use in prevention and treatment of infection.
kate spade - Las Vegas, Nevada Area Aug 2012 - Jan 2013
Sales Associate
Caesars Entertainment Corporation - Las Vegas, Nevada Area Jun 2011 - Jul 2011
Summer Intern
Education:
University of Nevada-Las Vegas 2010 - 2012
BA, Hospitality
George Fox University 2008 - 2009
BA, Business
Palleon Pharmaceuticals
Chief Scientific Officer
Medimmune Jun 2015 - Aug 2016
Senior Scientist
Medimmune Dec 1, 2010 - Jun 2015
Scientist Ii
Medimmune Jan 2007 - Dec 2010
Scientist I
Genentech Jun 2006 - Dec 2006
Intern
Education:
University of California, Davis 2001 - 2006
Doctorates, Doctor of Philosophy, Molecular Biology, Biochemistry
Capital Normal University 1998 - 2001
Master of Science, Masters
University of California
Skills:
Protein Chemistry Molecular Biology Assay Development Elisa Protein Purification Antibodies Biotechnology Cell Culture Biochemistry Protein Expression Cell Drug Discovery Life Sciences Purification Sds Page Protein Engineering High Throughput Screening Cell Biology Antibody Discovery and Engineering