Matthias A Oberli from 4 Rollins Ct, Cambridge, MA 02139, age 46, Phone: (617)4358990

Oligosaccharides And Oligosaccharide-Protein Conjugates Derived From Clostridium Difficile Polysaccharide Ps-Ii, Methods Of Synthesis And Uses Thereof, In Particular As A Vaccine
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US Patent:

20130344104, Dec 26, 2013
Filed:

Mar 7, 2012
Appl. No.:

14/003801
Inventors:

Peter H. Seeberger - Kleinmachnow, DE
Matthias Oberli - Cambridge MA, US
Marie-Lyn Hecht - Buchrain, CH
International Classification:

A61K 39/08
C08B 37/00
C07K 16/12
C07K 14/34
US Classification:

42419711, 530395, 5361231, 4242471, 5303875, 530363
Abstract:

The present invention provides an oligosaccharide-protein conjugate comprising an oligosaccharide, in particular synthetic oligosaccharide, derived from the repeating unit of the glycopolymer PS-II and a protein carrier. More specifically, the oligosaccharide is the hexasaccharide having the following formula (I) wherein R is a linker or spacer group. In a specific embodiment of the invention, R is (CH2)NH, with n being an integer from 2 to 50. The present invention also provides the use of said oligosaccharide and said oligosaccharide-protein conjugate for the treatment or prevention of a disease caused by the pathogen In still further aspects, the present invention also provides a favourable method for preparing said oligosaccharide and said oligosaccharide-protein conjugate.

Compositions, Devices, And Methods For Treating Fabry Disease
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US Patent:

20220267794, Aug 25, 2022
Filed:

Mar 27, 2020
Appl. No.:

17/598176
Inventors:

- Cambridge MA, US
Michael Beauregard - Boston MA, US
Guillaume Carmona - Cambridge MA, US
Francisco Caballero Gonzalez - Brookline MA, US
Richard Heidebrecht - Somerville MA, US
Erika Ellen Johnston - Cambridge MA, US
Robert James Miller - East Bridgewater MA, US
Owen O'Connor - Raynham MA, US
Matthias Alexander Oberli - Cambridge MA, US
David Peritt - Skokie IL, US
Jared A. Sewell - Somerville MA, US
Devyn McKinley Smith - Barrington RI, US
Omid Veiseh - Bellaire TX, US
Jeffrey Charles Way - Cambridge MA, US
Paul Kevin Wotton - Boston MA, US
Zoe Yin - Boston MA, US
Elina Makino - Winchester MA, US
Brian Richard Fluharty - Boston MA, US
Marianthi Papakosta - Cambridge MA, US
International Classification:

C12N 15/85
A61K 38/47
A61K 47/22
A61K 9/50
C08L 5/04
Abstract:

Described herein are RPE cells engineered to secrete a GLA protein, as well as compositions, pharmaceutical preparations, and implantable devices comprising the engineered RPE cells, and methods of making and using the same for treating Fabry disease.

Implantable Particles And Related Methods
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US Patent:

20210145759, May 20, 2021
Filed:

Mar 27, 2019
Appl. No.:

17/045127
Inventors:

- Cambridge MA, US
Michael Beauregard - Boston MA, US
Guillaume Carmona - Cambridge MA, US
Francisco Caballero Gonzalez - Brookline MA, US
Richard Heidebrecht - Somerville MA, US
Erika Ellen Johnston - Cambridge MA, US
Robert James Miller - East Bridgewater MA, US
Matthias Alexander Oberli - Cambridge MA, US
Owen O'Connor - Raynham MA, US
David Peritt - Skokie IL, US
Jared A. Sewell - Somerville MA, US
Devyn McKinley Smith - Barrington RI, US
Omid Veiseh - Bellaire TX, US
Paul Kevin Wotton - Boston MA, US
International Classification:

A61K 9/50
A61K 35/28
A61K 35/30
C07K 14/755
C07K 14/62
C12N 9/64
Abstract:

Described herein are particles comprising a first compartment, a second compartment, and a compound of Formula (I), as well as compositions and methods of making and using the same. The particles may comprise a cell capable of expressing a therapeutic agent useful for the treatment of a disease, disorder, or condition described herein.

Methods, Compositions, And Implantable Elements Comprising Active Cells
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US Patent:

20200263196, Aug 20, 2020
Filed:

Sep 27, 2018
Appl. No.:

16/651892
Inventors:

- Cambridge MA, US
Francisco Caballero Gonzalez - Brookline MA, US
Richard Heidebrecht - Somerville MA, US
Robert James Miller - East Bridgewater MA, US
Matthias Alexander Oberli - Cambridge MA, US
David Peritt - Skokie IL, US
Jared A. Sewell - Somerville MA, US
Devyn McKinley Smith - Barrington RI, US
Omid Veiseh - Bellaire TX, US
Paul Kevin Wotton - Boston MA, US
International Classification:

C12N 15/85
C12N 5/079
A61K 35/30
C07K 14/755
C07K 14/55
C07K 14/635
A61K 9/00
A61K 9/48
A61K 47/54
Abstract:

Described herein are cell compositions comprising an active cell (e.g., an engineered active cell, e.g., an engineered RPE cell) or derivatives thereof, as well as compositions, pharmaceutical products, and implantable elements comprising an active cell, and methods of making and using the same. The cells and compositions may express a therapeutic agent useful for the treatment of a disease, disorder, or condition described herein.

Compounds, Devices, And Uses Thereof
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US Patent:

20200039943, Feb 6, 2020
Filed:

Oct 3, 2017
Appl. No.:

16/339285
Inventors:

- Cambridge MA, US
Richard Heidebrecht - Somerville MA, US
Paul Kevin Wotton - Boston MA, US
Matthias Alexander Oberli - Cambridge MA, US
Robert James Miller - East Bridgewater MA, US
International Classification:

C07D 249/04
A61P 37/04
A61P 37/06
A61K 9/00
A61K 35/30
C07K 16/22
A61K 39/395
C12N 9/40
A61K 38/47
A61K 31/541
C07D 405/12
A61K 31/4192
C07D 295/088
A61K 31/54
C07H 15/26
A61K 31/7056
C07F 7/18
A61K 31/695
C07D 405/14
C07D 403/12
C07D 409/04
Abstract:

The present invention provides compounds, e.g., compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are implantable elements (e.g., devices and materials) comprising the same, as well as methods of use thereof, e.g., for treating or preventing a disease, disorder, or condition.

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Author
Matthias Oberli

ISBN #
3897390388

Matthias A Oberli