Michael Yi-Hsu Huang

US Patent:

7304781, Dec 4, 2007

Filed:

Jun 29, 2006

Appl. No.:

11/479986

Inventors:

Connie J. Chang-Hasnain - Palo Alto CA, US
Carlos Fernando Rondina Mateus - San Jose De Campos, BR
Michael Chung-Yi Huang - Berkeley CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

G02F 1/07

US Classification:

359260, 359245, 359238

Abstract:

A sub-wavelength grating structure that has a very broad reflection spectrum and very high reflectivity comprising segments made of high refractive index material disposed on a layer of low refractive index material and a low refractive index material disposed above and between the segments. The index differential between the high and low index materials determines the bandwidth and modulation depth. The larger difference in refractive indices gives rise to wider reflection bands. The reflection is sensitive to parameters such as the grating period, the grating thickness, the duty cycle of the grating, the refractive index and the thickness of the low index layer underneath the grating. The design is scalable for different wavelengths, and facilitates monolithic integration of optoelectronic devices at a wide range of wavelengths from visible to far infrared. The sub-wavelength grating reflectors may be used in a variety of settings such as tunable etalon filters and as a replacement for conventional distributed Bragg reflectors.

US Patent:

7472803, Jan 6, 2009

Filed:

Feb 25, 2005

Appl. No.:

11/067657

Inventors:

Krishan L. Kalra - Danville CA, US
Thomas Maxwell - Danville CA, US
Qi Cao - San Leandro CA, US
Michael Huang - San Ramon CA, US
Shahin Iqbal - Danville CA, US

Assignee:

BioGenex Laboratories, Inc. - San Ramon CA

International Classification:

B65G 59/06

US Classification:

221257, 221256, 221263

Abstract:

An automated dispensing assembly includes a base, and a shuttle mounted in the base and movable under automated control between a loading position and a dispensing position. The shuttle includes a cavity configured to carry an object, such as cover. The depth of the cavity in the shuttle is approximately the same (or less) as the thickness of one of the objects. A storage module is mounted proximate the shuttle. The storage module is configured to store a plurality of objects and includes an opening exposing the next object to be dispensed. The cavity is positioned adjacent the opening in the storage module in the loading position and an edge of the cavity separates the object to be dispensed from the other objects in the storage module as the shuttle moves to the dispensing position.

US Patent:

8448496, May 28, 2013

Filed:

Sep 22, 2010

Appl. No.:

12/924281

Inventors:

Michael Huang - San Jose CA, US
Mengya Wu - Santa Clara CA, US
Mengyou Wu - Santa Clara CA, US

Assignee:

Micropoint Bioscience Inc. - Santa Clara CA

International Classification:

G01N 9/00
G01N 11/10

US Classification:

73 32A, 73 5424

Abstract:

This invention provides methods and devices to measure physical characteristics of sample fluids. Samples are introduced into a sample chamber in contact with a mechanically oscillating working member. The vibrations are received by a piezoelectric sensor transducer and correlated to a sample characteristic, such as viscosity or density. The devices include a sample chamber in contact with one or more working members actuated by a piezoelectric actuator and/or monitored by a piezoelectric sensor.

US Patent:

8633711, Jan 21, 2014

Filed:

Sep 9, 2010

Appl. No.:

12/807698

Inventors:

Michael Huang - Santa Clara CA, US
Mengya Wu - Santa Clara CA, US
Mengyou Wu - Santa Clara CA, US

Assignee:

MicroPoint Bioscience, Inc. - Santa Clara CA

International Classification:

G01R 27/28
G01R 27/26

US Classification:

324656

Abstract:

This invention provides methods and devices for detecting the viscosity and conductivity of a conductive fluid sample. A sample fluid can be received into a sample chamber between a field inductor and sensor inductor. Electromagnetic fields generated by the field inductor can be modulated due to the counter-emf induced in the sample. The modulations can be detected by the sensor inductor and correlated to electric parameters in the fluid.

US Patent:

20070153860, Jul 5, 2007

Filed:

May 19, 2006

Appl. No.:

11/438480

Inventors:

Connie Chang-Hasnain - Palo Alto CA, US
Michael Huang - Berkeley CA, US
Ye Zhou - Berkeley CA, US
Carlos Mateus - Sao Jose De Campos-Sp, BR

International Classification:

H01S 5/00
G02B 27/42
G02B 5/18

US Classification:

372050124, 359558000

Abstract:

A vertical cavity surface emitting laser (VCSEL) is described using a sub-wavelength grating (SWG) structure that has a very broad reflection spectrum and very high reflectivity. The grating comprises segments of high and low refractive index materials with an index differential between the high and low index materials. By way of example, a SWG reflective structure is disposed over a low index cavity region and above another reflective layer (either SWG or DBR). In one embodiment, the SWG structure is movable, such as according to MEMS techniques, in relation to the opposing reflector to provide wavelength selective tuning. The SWG-VCSEL design is scalable to form the optical cavities for a range of SWG-VCSELs at different wavelengths, and wavelength ranges.

US Patent:

20220370364, Nov 24, 2022

Filed:

May 18, 2022

Appl. No.:

17/747844

Inventors:

- Redwood City CA, US
Aihua Zhu - Foster City CA, US
Kirk William Johnson - Moraga CA, US
Michael Huang - Ladera Ranch CA, US

International Classification:

A61K 9/19
C07K 16/24
A61K 47/26
A61K 47/18
C07K 16/28

Abstract:

Provided are high concentration stable formulations of anti-CSF1R/CSF1 antibodies. An example formulation includes 105 to 250 mg/mL of the antibody, 100 mM to 200 mM of arginine glutamate or arginine HCl, 10 mM to 50 mM histidine, and 0.015 to 0.035 w/v % of polysorbate 80, at a pH of 5.4 to 5.6. Also provided are methods of using the formulations for treating diseases.

US Patent:

20220183979, Jun 16, 2022

Filed:

Dec 13, 2021

Appl. No.:

17/549785

Inventors:

- Redwood City CA, US
Aihua Zhu - Foster City CA, US
Kirk William Johnson - Moraga CA, US
Michael Huang - Ladera Ranch CA, US

International Classification:

A61K 9/19
C07K 16/24
C07K 16/28
A61K 47/18
A61K 47/26

Abstract:

Provided are high concentration stable formulations of anti-CSF1R/CSF1 antibodies. An example formulation includes 105 to 250 mg/mL of the antibody, 100 mM to 200 mM of arginine glutamate or arginine HCl, 10 mM to 50 mM histidine, and 0.015 to 0.035 w/v % of polysorbate 80, at a pH of 5.4 to 5.6. Also provided are methods of using the formulations for treating diseases.

US Patent:

20230065193, Mar 2, 2023

Filed:

Aug 22, 2022

Appl. No.:

17/821459

Inventors:

- Redwood City CA, US
Laman Alani - Menlo Park CA, US
Michael Huang - Redwood City CA, US

International Classification:

A61K 9/00
C07K 16/28
A61P 35/00
A61P 19/02

Abstract:

The present disclosure provides compositions and methods for intra-articular delivery of anti-CSF1R antibodies to a tissue that is impacted by a disease that is treatable with CSF1/CSF1R inhibition and/or that expresses CSF1R. It was conventional knowledge that the intra-articular dwell time of proteins in joints is typically a few hours or less. The present disclosure shows, however, that intra-articular delivery of an anti-CSF1R antibody can lead to sustained exposure and pharmacologic activity of the antibody in the joints far beyond a few hours, providing an effective means for targeted and extended delivery of the therapeutic agent.