Michael L Liang

US Patent:

20020102405, Aug 1, 2002

Filed:

Jul 17, 2001

Appl. No.:

09/907551

Inventors:

Robert Chapman - Burlingame CA, US
Emanuele Ostuni - Cambridge MA, US
Michael Liang - Somerville MA, US
Lin Yan - East Brunswick NJ, US
George Whitesides - Newton MA, US

International Classification:

B32B009/04
B32B017/06
B32B013/04
B32B015/04
B32B027/00

US Classification:

428/411100, 428/426000, 428/446000, 428/457000, 428/500000

Abstract:

The present invention provides articles resistant to the adsorption of proteins, cells and bacteria. The articles can either have a chemical chain bonded thereon where the chemical chain can comprise a terminal group free of a hydrogen bond donor or where a hydrogen bond donor is sufficiently buried such that an exposed surface of the article including the chemical chain is free of a hydrogen bond donor. The chemical chain, or plurality of chemical chains, can comprise a monolayer such as a self-assembled monolayer (SAM) which can be homogeneous (one type of SAM) or mixed, i.e. or more different types of SAMs. Other more specific examples of chemical chains are provided. The plurality of chemical chains can comprise a polymer such as a polyamine. In many aspects, the plurality of chemical chains is sufficiently free of cross-linking or branching. The present invention also provides an article capable of specific binding of a desired biomolecule while preventing non-specific binding of biomolecules.

US Patent:

20050163648, Jul 28, 2005

Filed:

Jan 26, 2004

Appl. No.:

10/707919

Inventors:

MICHAEL LIANG - ALAMEDA CA, US

International Classification:

A61L002/00
A62B007/08
B01J019/08
A61L009/00

US Classification:

422001000, 422024000, 422121000, 422186000, 422305000

Abstract:

A sterilizing method and apparatus for destroying live microorganisms including viruses in fluent material, such as air and water, in large volume. As a preferred embodiment of this invention, air is drawn, from the inlet , through the inlet filter unit and into the circuitous sterilizing chamber that is irradiated by numbers of UV lamp tubes , and through the discharging filter unit and then out through outlet . A sample window is built in for quality supervision. Visual inspection windows and UV sensors are provided for easy supervision and auto-control. The sterilizing chamber also includes flow resistant reducing feature and internal reflecting surfaces