Michael J Lowe

US Patent:

20110105509, May 5, 2011

Filed:

Nov 3, 2010

Appl. No.:

12/938479

Inventors:

Neelu Kaila - Lexington MA, US
Eddine Saiah - Brookline MA, US
Bruce Christopher Follows - Littleton MA, US
Adrian Huang - Lexington MA, US
Kristin Marie Janz - Arlington MA, US
Michael Dennis Lowe - Boston MA, US
Alessandro Fabio Moretto - Somerville MA, US
Jennifer Romanic Thomason - Bedford MA, US
Tarek Suhayl Mansour - New City NY, US
Cara Margaret May Williams - Methuen MA, US

Assignee:

Wyeth, LLC - Madison NJ

International Classification:

A61K 31/502
C07D 403/04
A61K 31/501
C07D 401/06
A61K 31/4439
C07D 403/14
C07D 403/06
A61K 31/4725
C07D 417/14
C07D 401/14
A61P 11/00
A61P 1/00
A61P 17/00
A61P 29/00
A61P 37/06
A61P 37/08
C12N 5/02

US Classification:

514248, 544237, 544238, 51425206, 5462781, 514339, 546141, 514309, 435375

Abstract:

Disclosed are compounds of Formula (I):

US Patent:

61591580, Dec 12, 2000

Filed:

Jul 6, 1999

Appl. No.:

9/348195

Inventors:

Michael W. Lowe - Liberty MO

International Classification:

A61B 508

US Classification:

600529

Abstract:

An apparatus and method for identifying and marking regions of tissue obstruction in the upper airway of a patient. The invention provides a greatly improved method for use during a sleep apnea study to particularize the location of a region of obstruction. The precise location of the obstruction may be marked for surgical removal or reduction. Broadly speaking, the apparatus includes a multiluminate catheter having an outer wall circumscribed by multiple discrete perforate regions. The proximal portion of each lumen opens into a selected perforate region and the distal portion is coupled with a pressure transducer. Each lumen is equipped with a syringe port for injecting a tissue marking dye into the obstructing tissue region. The catheter outer wall may include a radiopaque marker in order to facilitate location of the catheter within the airway of a patient.

US Patent:

20200377511, Dec 3, 2020

Filed:

Aug 18, 2020

Appl. No.:

16/996117

Inventors:

- New York NY, US
Katherine Lin Lee - West Newton MA, US
Mark Edward Bunnage - Concord MA, US
Seungil Han - Mystic CT, US
David Hepworth - Concord MA, US
Frank Eldridge Lovering - Acton MA, US
John Paul Mathias - Concord MA, US
Nikolaos Papaioannou - Newton MA, US
Betsy Susan Pierce - East Lyme CT, US
Joseph Walter Strohbach - Wentzville MO, US
Stephen Wayne Wright - Old Lyme CT, US
Christoph Wolfgang Zapf - Marlborough MA, US
Lori Krim Gavrin - Villanova PA, US
Arthur Lee - San Carlos CA, US
David Randolph Anderson - Salem CT, US
Kevin Joseph Curran - Somerset NJ, US
Christoph Martin Dehnhardt - Burnaby, CA
Eddine Saiah - Brookline MA, US
Joel Adam Goldberg - New Orleans LA, US
Xiaolun Wang - San Diego CA, US
Horng-Chih Huang - Chesterfield MO, US
Richard Vargas - Bedford MA, US
Michael Dennis Lowe - White Plains NY, US
Akshay Patny - Waltham MA, US

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D 491/056
C07F 7/18
C07D 401/14
C07D 405/14
C07D 217/02
C07D 217/22
C07D 217/24
C07C 69/94
C07D 239/86
C07D 239/88
C07D 263/24
C07D 207/273
C07D 498/04
C07D 209/52
A61K 31/4015
A61K 31/47
A61K 31/4709
A61K 31/4725
A61K 31/517
A61K 31/5377
A61K 31/541
A61K 45/06
C07D 207/26
C07D 215/48
C07D 401/12
C07D 403/12
C07D 405/12
C07D 407/14
C07D 413/12
C07D 417/12
C07D 487/04
A61K 31/40
C07D 207/08
C07D 207/267

Abstract:

Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia,as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

US Patent:

20200138141, May 7, 2020

Filed:

Nov 1, 2019

Appl. No.:

16/671770

Inventors:

- Redwood City CA, US
David Stoutamire - Menlo Park CA, US
Michael Lowe - Santa Cruz CA, US

International Classification:

A42B 3/06
A42B 3/20
A42B 3/12
A42B 3/04

Abstract:

A helmet may be worn on a head of a wearer having a shape and a contour. The helmet may have a plurality of layers coupled together including an energy management layer and an outer shell layer disposed over the energy management layer. The plurality of layers are integrally formed with one another, and the energy management layer is configured to absorb and dissipate energy received by the helmet during an impact by an external force. The outer shell layer is configured to disperse and dissipate impact energy from the external force. Each of the plurality of layers has a density and a geometry, and the density or geometry of at least one layer differs from the density or geometry of at least another layer.

US Patent:

20190270751, Sep 5, 2019

Filed:

May 14, 2019

Appl. No.:

16/411679

Inventors:

- New York NY, US
Katherine Lin Lee - West Newton MA, US
Mark Edward Bunnage - Concord MA, US
Seungil Han - Mystic CT, US
David Hepworth - Concord MA, US
Frank Eldridge Lovering - Acton MA, US
John Paul Mathias - Concord MA, US
Nikolaos Papaioannou - Newton MA, US
Betsy Susan Pierce - East Lyme CT, US
Joseph Walter Strohbach - Wentzville MO, US
Stephen Wayne Wright - Old Lyme CT, US
Christoph Wolfgang Zapf - Marlborough MA, US
Lori Krim Gavrin - Villanova PA, US
Arthur Lee - San Carlos CA, US
David Randolph Anderson - Salem CT, US
Kevin Joseph Curran - Somerset NJ, US
Christoph Martin Dehnhardt - Burnaby, CA
Eddine Saiah - Brookline MA, US
Joel Adam Goldberg - New Orleans LA, US
Xiaolun Wang - San Diego CA, US
Horng-Chih Huang - Chesterfield MO, US
Richard Vargas - Bedford MA, US
Michael Dennis Lowe - White Plains NY, US
Akshay Patny - Waltham MA, US

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D 491/056
C07F 7/18
A61K 31/4015
C07D 207/267
C07D 207/08
C07D 209/52
C07D 498/04
C07D 207/273
C07D 263/24
C07D 239/88
C07D 239/86
C07C 69/94
C07D 217/24
C07D 217/22
C07D 217/02
C07D 405/14
C07D 401/14
C07D 487/04
A61K 31/47
A61K 31/4709
A61K 31/4725
A61K 31/517
A61K 31/5377
A61K 31/541
A61K 45/06
C07D 207/26
C07D 215/48
C07D 401/12
C07D 403/12
C07D 405/12
C07D 407/14
C07D 413/12
C07D 417/12
A61K 31/40

Abstract:

Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia,as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

US Patent:

20180127432, May 10, 2018

Filed:

Jan 5, 2018

Appl. No.:

15/862691

Inventors:

- New York NY, US
Katherine Lin Lee - West Newton MA, US
Mark Edward Bunnage - Concord MA, US
Seungil Han - Mystic CT, US
David Hepworth - Concord MA, US
Frank Eldridge Lovering - Acton MA, US
John Paul Mathias - Concord MA, US
Nikolaos Papaioannou - Newton MA, US
Betsy Susan Pierce - East Lyme CT, US
Joseph Walter Strohbach - Wentzville MO, US
Stephen Wayne Wright - Old Lyme CT, US
Christoph Wolfgang Zapf - Marlborough MA, US
Lori Krim Gavrin - Villanova PA, US
Arthur Lee - Littleton MA, US
David Randolph Anderson - Salem CT, US
Kevin Joseph Curran - Somerset NJ, US
Christoph Martin Dehnhardt - Burnaby, CA
Eddine Saiah - Brookline MA, US
Joel Adam Goldberg - New Orleans LA, US
Xiaolun Wang - San Diego CA, US
Horng-Chih Huang - Chesterfield MO, US
Richard Vargas - Bedford MA, US
Michael Dennis Lowe - White Plains NY, US
Akshay Patny - Waltham MA, US

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D 491/056
C07D 239/88
C07D 239/86
C07D 263/24
C07D 207/267
A61K 31/40
C07D 207/08
C07F 7/18
C07D 209/52
C07D 498/04
C07D 207/273
C07C 69/94
C07D 217/24
C07D 217/22
C07D 217/02
C07D 405/14
C07D 401/14
C07D 487/04
A61K 31/47
A61K 31/4709
A61K 31/4725
A61K 31/517
A61K 31/5377
A61K 31/541
A61K 45/06
C07D 407/14
C07D 215/48
C07D 207/26
C07D 401/12
C07D 403/12
C07D 405/12
C07D 413/12
C07D 417/12
A61K 31/4015

Abstract:

Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia,as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

US Patent:

20160347760, Dec 1, 2016

Filed:

Aug 10, 2016

Appl. No.:

15/232892

Inventors:

- New York NY, US
Katherine Lin Lee - West Newton MA, US
Mark Edward Bunnage - Concord MA, US
Seungil Han - Mystic CT, US
David Hepworth - Concord MA, US
Frank Eldridge Lovering - Acton MA, US
John Paul Mathias - Concord MA, US
Nikolaos Papaioannou - Newton MA, US
Betsy Susan Pierce - East Lyme CT, US
Joseph Walter Strohbach - Wentzville MO, US
Stephen Wayne Wright - Old Lyme CT, US
Christoph Wolfgang Zapf - Marlborough MA, US
Lori Krim Gavrin - Villanova PA, US
Arthur Lee - Littleton MA, US
David Randolph Anderson - Salem CT, US
Kevin Joseph Curran - Somerset NJ, US
Christoph Martin Dehnhardt - Burnaby, CA
Eddine Saiah - Brookline MA, US
Joel Adam Goldberg - New Orleans LA, US
Xiaolun Wang - San Diego CA, US
Horng-Chih Huang - Chesterfield MO, US
Richard Vargas - Bedford MA, US
Michael Dennis Lowe - White Plains NY, US
Akshay Patny - Waltham MA, US

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D 491/056
A61K 31/4709
C07D 405/12
C07D 215/48
A61K 31/47
A61K 31/4725
C07D 417/12
A61K 31/541
C07D 413/12
A61K 31/5377
C07D 207/267
A61K 31/4015
C07D 207/08
A61K 31/40
C07D 407/14
C07D 487/04
C07D 403/12
A61K 31/517
A61K 45/06
C07D 401/12

Abstract:

Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia,as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

US Patent:

20150284405, Oct 8, 2015

Filed:

Apr 3, 2015

Appl. No.:

14/678114

Inventors:

- New York NY, US
Katherine Lin Lee - West Newton MA, US
Mark Edward Bunnage - Concord MA, US
Seungil Han - Mystic CT, US
David Hepworth - Concord MA, US
Frank Eldridge Lovering - Acton MA, US
John Paul Mathias - Concord MA, US
Nikolaos Papaioannou - Boston MA, US
Betsy Susan Pierce - East Lyme CT, US
Joseph Walter Strohbach - Wentzville MO, US
Stephen Wayne Wright - Old Lyme CT, US
Christoph Wolfgang Zapf - Marlborough MA, US
Lori Krim Gavrin - Villanova PA, US
Arthur Lee - Gaithersburg MD, US
David Randolph Anderson - Salem CT, US
Kevin Joseph Curran - Somerset NJ, US
Christoph Martin Dehnhardt - Burnaby, CA
Eddine Saiah - Brookline MA, US
Joel Adam Goldberg - New Orleans LA, US
Xiaolun Wang - San Diego CA, US
Horng-Chih Huang - Chesterfield MO, US
Richard Vargas - Bedford MA, US
Michael Dennis Lowe - White Plains NY, US
Akshay Patny - Waltham MA, US

Assignee:

Pfizer Inc. - New York NY

International Classification:

C07D 491/056
A61K 31/4709
A61K 45/06
C07D 405/12
C07D 215/48
A61K 31/47
A61K 31/4725
C07D 417/12
A61K 31/541
C07D 413/12
A61K 31/5377
C07D 207/26
A61K 31/4015
C07D 407/14
C07D 487/04
C07D 403/12
A61K 31/517
C07D 401/12

Abstract:

Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula Ia,as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.