Peng Zhou

US Patent:

6722403, Apr 20, 2004

Filed:

Jan 24, 2002

Appl. No.:

10/057370

Inventors:

Peng Zhou - Newtown PA
Edward Joseph Kuspiel - Rahway NJ
Waldemar Ruediger - New Hope PA
Alexander Bertok - Edison NJ
Carl J. Trpisovsky - Kendall Park NJ

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

F62B 1100

US Classification:

141129, 141 83, 141153, 141178, 141181, 141233, 222 52, 222 77, 222413

Abstract:

A bifurcated bracket carries two powder dispensing assemblies. Each assembly includes a powder reservoir and a rotatable screw received within a compliant silicone sleeve. The outer diameter of the screw is slightly larger than the inner diameter of the sleeve such that the screw blade maintains direct contact with the sleeve wall as the screw is rotated. The bracket is sequentially moved to align each assembly with containers in two arrays. Each array of containers is situated in a tray. The trays are manually positioned on independent scales which generate signals that are a function of the sensed weight of each array. To fill each container, the screw in the aligned assembly is rotated at a high rate for an initial period and then at a slower rate. The scales are operational only during the slower rate period. Assembly movement and screw rotation are computer controlled.

US Patent:

7011793, Mar 14, 2006

Filed:

Mar 23, 2004

Appl. No.:

10/807051

Inventors:

Peng Zhou - Newtown PA, US
Lincoln Young - Ithaca NY, US

Assignee:

Kionix, Inc. - Ithaca NY

International Classification:

B01L 3/02
B01L 11/00
B01L 3/00
G01N 15/06
G01N 21/00

US Classification:

422100, 422 50, 422 55, 422 58, 422 681, 422 81, 422 82, 422 8205, 422101, 422102, 422103, 422104, 436 43, 436 52, 436 53, 436 63, 29592, 295921

Abstract:

A reconfigurable modular microfluidic system, providing a microfluidic breadboard platform for the formation of fluidic network and fluidic sealing upon a system assembly. Modular microfluidic elements or “chips” are arranged on a precisely machined alignment base to form a fluidic network, with fluid connections provided directly from chip-to-chip at overlapping corners. Fluidic access to external devices is possible at every fluid connection and through special ingress/egress chips. By maintaining a largely planar layout, optical access is provided for detecting or visualization for every chip. The assembly may be covered by a perforated cover plate.

US Patent:

7608160, Oct 27, 2009

Filed:

Oct 13, 2004

Appl. No.:

10/964216

Inventors:

Peng Zhou - Newtown PA, US
Lincoln C. Young - Ithaca NY, US

Assignee:

Rheonix, Inc. - Ithaca NY

International Classification:

B32B 38/04

US Classification:

1562722, 1562733, 1562737, 156285, 422102

Abstract:

A method for making a polymeric microfluidic structure in which two or more components (layers) of the microfluidic structure are fixedly bonded or laminated with a weak solvent bonding agent, particularly acetonitrile or a mixture of acetonitrile and alcohol. In an aspect, acetonitrile can be used as a weak solvent bonding agent to enclose a microstructure fabricated in or on a non-elastomeric polymer such as polystyrene, polycarbonate, acrylic or other linear polymer to form a three-dimensional microfluidic network. The method involves the steps of wetting at least one of the opposing surfaces of the polymeric substrate components with the weak solvent bonding agent in a given, lower temperature range, adjacently contacting the opposing surfaces, and thermally activating the bonding agent at a higher temperature than the lower temperature range for a given period of time. The contacted polymeric substrates may also be aligned prior to thermal activation and compressed during thermal activation. A laminated, polymeric microfluidic structure is also disclosed.

US Patent:

7837821, Nov 23, 2010

Filed:

Feb 20, 2008

Appl. No.:

12/033958

Inventors:

Peng Zhou - Newtown PA, US
Lincoln C. Young - Ithaca NY, US
Todd Roswech - Ithaca NY, US

Assignee:

Rheonix, Inc. - Ithaca NY

International Classification:

B32B 38/04

US Classification:

1562722, 1562728, 1562733, 1562737, 156285, 422102

Abstract:

A method for making a polymeric microfluidic structure in which two or more components (layers) of the microfluidic structure are fixedly bonded or laminated with a weak solvent bonding agent, particularly acetonitrile or a mixture of acetonitrile and alcohol. In an aspect, acetonitrile can be used as a weak solvent bonding agent to enclose a microstructure fabricated in or on a non-elastomeric polymer such as polystyrene, polycarbonate, acrylic or other linear polymer to form a three-dimensional microfluidic network. The method involves the steps of wetting at least one of the opposing surfaces of the polymeric substrate components with the weak solvent bonding agent in a given, lower temperature range, adjacently contacting the opposing surfaces, and thermally activating the bonding agent at a higher temperature than the lower temperature range for a given period of time with RF or ultrasonic energy. The contacted polymeric substrates may also be aligned prior to thermal activation and compressed during thermal activation. A laminated, polymeric microfluidic structure is also disclosed.

US Patent:

7959875, Jun 14, 2011

Filed:

Jan 5, 2007

Appl. No.:

11/650006

Inventors:

Peng Zhou - Newtown PA, US
Lincoln Young - Ithaca NY, US

Assignee:

Rheonix, Inc. - Ithaca NY

International Classification:

B01L 3/00

US Classification:

422502, 422501

Abstract:

The systems and methods described herein include a microfluidic chip having a plurality of microfeatures interconnected to provide a configurable fluid transport system for processing at least one reagent. Inserts are provided to removably interfit into one or more of the microfeatures of the chip, wherein the inserts include sites for interactions with the reagent. As will be seen from the following description, the microfluidic chip and the inserts provide an efficient and accurate approach for conducting parallel assays.

US Patent:

7976795, Jul 12, 2011

Filed:

Nov 8, 2006

Appl. No.:

11/594444

Inventors:

Peng Zhou - Newtown PA, US
Lincoln Young - Ithaca NY, US

Assignee:

Rheonix, Inc. - Ithaca NY

International Classification:

B01L 3/00
F04B 19/00
G01N 1/10

US Classification:

422505, 422500, 422501, 422502, 422503, 422504, 436180

Abstract:

The systems and methods disclosed herein include a microfluidic system, comprising a pneumatic manifold having a plurality of apertures, and a chip manifold having channels disposed therein for routing pneumatic signals from respective ones of the apertures to a plurality of valves in a microfluidic chip, wherein the channels route the pneumatic signals in accordance with a configuration of the plurality of valves in the microfluidic chip.

US Patent:

8057629, Nov 15, 2011

Filed:

Aug 12, 2009

Appl. No.:

12/539797

Inventors:

Peng Zhou - Newtown PA, US
Lincoln C. Young - Ithaca NY, US

Assignee:

Rheonix, Inc. - Ithaca NY

International Classification:

B32B 38/04

US Classification:

1562722, 1562728, 1562733, 1562737, 156285, 422502, 422503

Abstract:

A method for making a polymeric microfluidic structure in which two or more components (layers) of the microfluidic structure are fixedly bonded or laminated with a weak solvent bonding agent, particularly acetonitrile or a mixture of acetonitrile and alcohol. In an aspect, acetonitrile can be used as a weak solvent bonding agent to enclose a microstructure fabricated in or on a non-elastomeric polymer such as polystyrene, polycarbonate, acrylic or other linear polymer to form a three-dimensional microfluidic network. The method involves the steps of wetting at least one of the opposing surfaces of the polymeric substrate components with the weak solvent bonding agent in a given, lower temperature range, adjacently contacting the opposing surfaces, and thermally activating the bonding agent at a higher temperature than the lower temperature range for a given period of time. The contacted polymeric substrates may also be aligned prior to thermal activation and compressed during thermal activation. A laminated, polymeric microfluidic structure is also disclosed.

US Patent:

8101428, Jan 24, 2012

Filed:

Jun 3, 2011

Appl. No.:

13/152881

Inventors:

Peng Zhou - Newtown PA, US
Lincoln C. Young - Ithaca NY, US

Assignee:

Rheonix, Inc. - Ithaca NY

International Classification:

B01L 3/00
F04B 19/00
G01N 1/10

US Classification:

436180, 422500, 422501, 422502, 422503, 422504, 422505

Abstract:

The systems and methods disclosed herein include a microfluidic system, comprising a pneumatic manifold having a plurality of apertures, and a chip manifold having channels disposed therein for routing pneumatic signals from respective ones of the apertures to a plurality of valves in a microfluidic chip, wherein the channels route the pneumatic signals in accordance with a configuration of the plurality of valves in the microfluidic chip.