Peter M Mccann

US Patent:

52140504, May 25, 1993

Filed:

Mar 5, 1992

Appl. No.:

7/846656

Inventors:

Alan J. Bitonti - Maineville OH
Peter P. McCann - Lebanon IN
Albert Sjoerdsma - Cincinnati OH

Assignee:

Merrell Dow Pharmaceuticals Inc. - Cincinnati OH

International Classification:

A01N 4342
A61K 3144

US Classification:

514299

Abstract:

Red blood cells which are infected with the parasite P. falciparum cause the cells to become sticky and less deformable. This results in a build-up of cells on the vascular wall and creates occlusions to blood flow which are thought to cause the cerebral, renal and liver complications of P. falciparum infections. Certain esters of castanospermine prevent or reduce the adhesion of falciparum infected blood cells to the vascular endothelial wall and are a useful adjunct in the treatment of malaria.

US Patent:

57537143, May 19, 1998

Filed:

Mar 15, 1994

Appl. No.:

8/213386

Inventors:

David M. Stemerick - Fairfield OH
Alan J. Bitonti - Maineville OH
Michael L. Edwards - Cincinnati OH
Peter P. McCann - Cincinnati OH
Albert Sjoerdsma - Cincinnati OH

Assignee:

Merrell Pharmaceuticals Inc. - Cincinnati OH

International Classification:

A61K 31135
C07C21143

US Classification:

514654

Abstract:

This invention relates to certain polyamine derivatives, to the methods and intermediates useful for their preparation, and to their use in treating diseases caused by infestation with a variety of parasitic protozoa.

US Patent:

51964503, Mar 23, 1993

Filed:

Sep 30, 1991

Appl. No.:

7/768789

Inventors:

Albert Sjoerdsma - Cincinnati OH
Peter P. McCann - Lebanon IN
Philippe Bey - Cincinnati OH
Patrick J. Casara - Fairfield OH

Assignee:

Merrell Dow Pharmaceuticals Inc. - Cincinnati OH

International Classification:

A61K 31195

US Classification:

514565

Abstract:

This invention relates to the use of. alpha. - halomethyl,. alpha. -acetylenic or. alpha. -allenic derivatives of arginine and agmatine, or their dehydro analogs, in the treatment of Chagas disease and Coccidiosis.

US Patent:

47600918, Jul 26, 1988

Filed:

Feb 18, 1987

Appl. No.:

7/016026

Inventors:

Chrislyn M. Carson - Antioch CA
Peter P. McCann - Cincinnati OH

Assignee:

The Dow Chemical Company - Midland MI

International Classification:

A01N 3712
A01N 3744
A01N 3706

US Classification:

514561

Abstract:

This invention relates to a method of controlling phytopathogenic rust and smut fungi of the Uredinales order in a plant locus which comprises applying a fungicidally effective amount of an ornithine decarboxylase inhibitor.

US Patent:

43991513, Aug 16, 1983

Filed:

May 11, 1981

Appl. No.:

6/262275

Inventors:

Albert Sjoerdsma - Cincinnati OH
Peter P. McCann - Cincinnati OH

Assignee:

Merrell Dow Pharmaceuticals Inc. - Cincinnati OH

International Classification:

A61K 31195
A61K 3113
A61K 3170

US Classification:

424319

Abstract:

alpha. -Substituted amines and. alpha. -substituted-. alpha. -amino acids are described which are useful in inhibiting the growth of protozoa in animals.