Peter G Varlashkin

US Patent:

61073024, Aug 22, 2000

Filed:

Sep 22, 1997

Appl. No.:

8/875173

Inventors:

Barry Howard Carter - Kinston NC
Jane Muse Partin - Raleigh NC
Peter Gregory Varlashkin - Clayton NC
Richard Augustus Winnike - Durham NC
William Bayne Grubb - Athens GA
Gregory Alan Conway - Greenville SC
Philip George Lake - Dartford, GB
David Michael Skinner - Dartford, GB
David James Whatrup - Dartford, GB

Assignee:

Glaxo Wellcome Inc. - Research Triangle Park NC

International Classification:

A01N 4390
C07F 502
C07F 902
C07D47300

US Classification:

514262

Abstract:

The invention relates to an anhydrous crystalline form of (2-[2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy]ethyl L-valinate hydrochloride (otherwise known as valaciclovir hydrochloride) and a process for preparing it.

US Patent:

20220267257, Aug 25, 2022

Filed:

Aug 3, 2021

Appl. No.:

17/393144

Inventors:

- Stamford CT, US
Jiping LIU - Stamford CT, US
Ricky Wayne COUCH - Durham NC, US
Peter Gregory VARLASHKIN - Durham NC, US
Mai LI - Greenville SC, US
Yonghong GAN - Simpsonville SC, US

Assignee:

SpringWorks Therapeutics Inc. - Stamford CT

International Classification:

C07C 259/10
A61K 9/00
A61K 9/20
A61K 9/48

Abstract:

The present disclosure relates to: a) crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide; b) pharmaceutical compositions comprising one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide, and, optionally, one or more pharmaceutically acceptable carriers; c) methods of treating a tumor a cancer, or a Rasopathy disorder by administering one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide to a subject in need thereof; and methods of producing essentially pure Form IV of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide.

US Patent:

20230032403, Feb 2, 2023

Filed:

Jun 14, 2022

Appl. No.:

17/806821

Inventors:

- Stamford CT, US
Jiping LIU - Stamford CT, US
Ricky Wayne COUCH - Durham NC, US
Peter Gregory VARLASHKIN - Durham NC, US
Mai LI - Greenville SC, US
Yonghong GAN - Simpsonville SC, US

Assignee:

SpringWorks Therapeutics Inc. - Stamford CT

International Classification:

C07C 259/10
A61K 9/00
A61K 9/20
A61K 9/48

Abstract:

The present disclosure relates to: a) crystalline forms of N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide; b) pharmaceutical compositions comprising one or more crystalline forms of N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide, and, optionally, one or more pharmaceutically acceptable carriers; c) methods of treating a tumor a cancer, or a Rasopathy disorder by administering one or more crystalline forms of N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide to a subject in need thereof; and methods of producing essentially pure Form IV of N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide.