Qi I Zhao

US Patent:

20020053091, May 2, 2002

Filed:

Mar 26, 2001

Appl. No.:

09/816685

Inventors:

Ishwar Chandramouliswaran - Silver Spring MD, US
Qi Zhao - Gaithersburg MD, US
Karen Ketchum - Germantown MD, US
Valentina Di Francesco - Rockville MD, US
Ellen Beasley - Darnestown MD, US

International Classification:

A01K067/00
C07H021/04
C12P021/02
C12N005/06
C07K014/705

US Classification:

800/008000, 530/350000, 435/069100, 435/325000, 435/320100, 536/023500

Abstract:

The present invention provides amino acid sequences of peptides that are encoded by genes within the Human genome, the GPCR peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the GPCR peptides and methods of identifying modulators of the GPCR peptides.

US Patent:

20020064822, May 30, 2002

Filed:

Mar 26, 2001

Appl. No.:

09/816087

Inventors:

Ming-Hui Wei - Germantown MD, US
Wei Shao - Frederick MD, US
Qi Zhao - Gaithersburg MD, US
Valentina Di Francesco - Rockville MD, US
Ellen Beasley - Darnestown MD, US

International Classification:

C12P021/02
C12N005/06
C12Q001/68
C07H021/04
C07K014/705

US Classification:

435/069100, 435/006000, 435/325000, 530/350000, 536/023500

Abstract:

The present invention provides amino acid sequences of peptides that are encoded by genes within the Human genome, the GPCR peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the GPCR peptides and methods of identifying modulators of the GPCR peptides.

US Patent:

20030049790, Mar 13, 2003

Filed:

Oct 15, 2002

Appl. No.:

10/270144

Inventors:

Ming-Hui Wei - Germantown MD, US
Qi Zhao - Gaithersburg MD, US
Anibal Cravchik - Gaithersburg MD, US
Valentina Di Francesco - Rockville MD, US
Ellen Beasley - Darnestown MD, US

Assignee:

APPLERA CORPORATION - Norwalk CT

International Classification:

C12P021/02
C12N005/06
G01N033/53
C07H021/04
C07K014/705

US Classification:

435/069100, 435/320100, 435/325000, 530/350000, 536/023500, 435/007100

Abstract:

The present invention provides amino acid sequences of peptides that are encoded by genes within the Human genome, the GPCR peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the GPCR peptides and methods of identifying modulators of the GPCR peptides.

US Patent:

20030059891, Mar 27, 2003

Filed:

Oct 9, 2002

Appl. No.:

10/266643

Inventors:

Ming-Hui Wei - Germantown MD, US
Wei Shao - Frederick MD, US
Qi Zhao - Gaithersburg MD, US
Valentina Di Francesco - Rockville MD, US
Ellen Beasley - Darnestown MD, US

Assignee:

APPLERA CORPORATION - Norwalk CT

International Classification:

C12P021/02
C12N005/06
C07K014/705
C07H021/04

US Classification:

435/069100, 435/320100, 435/325000, 530/350000, 536/023500

Abstract:

The present invention provides amino acid sequences of peptides that are encoded by genes within the Human genome, the GPCR peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the GPCR peptides and methods of identifying modulators of the GPCR peptides.

US Patent:

20040033565, Feb 19, 2004

Filed:

Aug 13, 2003

Appl. No.:

10/639708

Inventors:

Ishwar Chandramouliswaran - Silver Spring MD, US
Qi Zhao - Gaithersburg MD, US
Karen Ketchum - Germantown MD, US
Valentina Di Francesco - Rockville MD, US
Ellen Beasley - Darnestown MD, US

Assignee:

APPLERA CORPORATION - Norwalk CT

International Classification:

C07K014/705
C07H021/04
C12P021/02
C12N005/06
C12N015/86
C07K017/00
C07K014/00
C07K001/00
C12N005/02
C12N005/00
C12N015/74
C12N015/70
C12N015/63
C12N015/09
C12N015/00
C12P021/06

US Classification:

435/069100, 435/320100, 435/325000, 435/456000, 530/350000, 536/023500

Abstract:

The present invention provides amino acid sequences of peptides that are encoded by genes within the Human genome, the GPCR peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the GPCR peptides and methods of identifying modulators of the GPCR peptides.

US Patent:

20040076951, Apr 22, 2004

Filed:

May 31, 2001

Appl. No.:

09/867570

Inventors:

Ming-Hui Wei - Rockville MD, US
Qi Zhao - Rockville MD, US
Trevor Woodage - Rockville MD, US
Valentina Di Francesco - Rockville MD, US
Ellen Beasley - Rockville MD, US

International Classification:

C12Q001/68
C07H021/04
C07K014/705

US Classification:

435/006000, 435/069100, 435/320100, 435/325000, 530/350000, 536/023500

Abstract:

The present invention provides amino acid sequences of peptides that are encoded by genes within the Human genome, the GPCR peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the GPCR peptides and methods of identifying modulators of the GPCR peptides.

US Patent:

20140044720, Feb 13, 2014

Filed:

Apr 11, 2012

Appl. No.:

14/111507

Inventors:

Dimiter S. Dimitrov - Frederick MD, US
Zhongyu Zhu - Frederick MD, US
Qi Zhao - Frederick MD, US

Assignee:

Department of Health and Human Service - Besthesda MD

International Classification:

C07K 16/22
G01N 33/74

US Classification:

4241361, 53038815, 4241421, 536 2353, 436501, 4353201, 43525233, 435336, 514 44 R

Abstract:

Disclosed herein are human monoclonal antibodies that specifically bind both IGF-I and IGF-II with picomolar affinity and potently inhibit the IGF-IR signal transduction function. These antibodies are active in both an IgG and a scFv format. Bispecific forms of these antibodies are also disclosed. Nucleic acids encoding these antibodies, vectors including these nucleic acids, and host cells transformed with these vectors are also disclosed herein. Also disclosed are pharmaceutical compositions including these antibodies. Methods are provided for treating a subject with cancer and for inhibiting phosphorylation of the insulin-like growth factor-I receptor. Methods are also provided for diagnosing cancer.

US Patent:

20190259474, Aug 22, 2019

Filed:

Feb 18, 2019

Appl. No.:

16/278611

Inventors:

- Tarrytown NY, US
Ying Huang - Ardsley NY, US
Wei Wang - Elmsford NY, US
Qi Zhao - Chappaqua NY, US

International Classification:

G16C 20/70
G16C 99/00
G16C 60/00
G16C 20/30
G16C 20/40
G16C 20/50
G16C 20/90

Abstract:

Methods for training a generative adversarial network (GAN) in conjunction with a convolutional neural network (CNN) are disclosed. The GAN and the CNN can be trained using biological data, such as protein interaction data. The CNN can be used for identifying new data as positive or negative. Methods are disclosed for synthesizing a polypeptide associated with new protein interaction data identified as positive.