Robert Louis Chao

US Patent:

6414536, Jul 2, 2002

Filed:

Aug 4, 2000

Appl. No.:

09/632407

Inventors:

Robert L. Chao - Los Altos CA 94022

International Classification:

H03K 1772

US Classification:

327540, 327563

Abstract:

An improved voltage reference circuit relies on electrically adjustable analog devices fabricated on a common substrate. The circuit has two electrically adjustable matched transistor pairs. A first matched transistor pair includes an adjusting transistor and a differential pair transistor. A second matched transistor pair also includes an adjusting transistor and a differential pair transistor. Each of the matched transistor pairs share an insulated gate or electrically connected insulated gates. Geometrical and electrical matching occurs as between the two adjusting transistors and between the two differential pair transistors. The two differential pair transistors are electrically connected at the source terminals to form a differential circuit. A feedback loop, which includes an amplifier, a fixed resistor and a current source complete the circuit.

US Patent:

7320990, Jan 22, 2008

Filed:

Feb 11, 2005

Appl. No.:

11/057009

Inventors:

Robert Chao - Santa Clara CA, US
Miroslav Rapta - Sunnyvale CA, US
Pierre-Jean Colson - San Francisco CA, US
Junning Lee - El Granada CA, US

Assignee:

Theravance, Inc. - South San Francisco CA

International Classification:

C07D 211/56
C07D 211/72
A61K 31/47

US Classification:

514317, 546224, 546304, 546312

Abstract:

The invention provides a crystalline naphthalene-1,5-disulfonic acid salt of biphenyl-2-ylcarbamic acid 1-{9-[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydro-quinolin-5 -yl)ethylamino]nonyl}piperidin-4-yl ester or a solvate thereof. This invention also provides pharmaceutical compositions comprising such a salt or prepared using such a salt; processes and intermediates for preparing such a salt; and methods of using such a salt to treat a pulmonary disorder.

US Patent:

7521558, Apr 21, 2009

Filed:

Aug 15, 2005

Appl. No.:

11/204065

Inventors:

Robert S. Chao - Santa Clara CA, US
Miroslav Rapta - Sunnyvale CA, US
Pierre-Jean Colson - San Francisco CA, US

Assignee:

Theravance, Inc. - South San Francisco CA

International Classification:

C07D 453/04
C07D 211/56

US Classification:

546135, 546224, 546242

Abstract:

The invention provides a crystalline 1,2-ethanedisulfonic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-5-methoxyphenylcarbamoyl)ethyl]piperidin-4-yl ester or a solvate thereof. This invention also provides pharmaceutical compositions comprising such a salt or prepared using such a salt; processes and intermediates for preparing such a salt; and methods of using such a salt to treat a pulmonary disorder.

US Patent:

7524880, Apr 28, 2009

Filed:

Jun 9, 2005

Appl. No.:

11/148728

Inventors:

Li Li - Sunnyvale CA, US
Robert Chao - Santa Clara CA, US
Adam Hughes - Belmont CA, US
Yu-Hua Ji - Redwood City CA, US
Davar Khossravi - San Mateo CA, US
Weijiang Zhang - Concord CA, US

Assignee:

Theravance, Inc. - South San Francisco CA

International Classification:

A61K 31/40
C07D 207/09

US Classification:

514428, 548571

Abstract:

The invention provides a crystalline naphthalene-1,5-disulfonic acid salt of 2-[(S)-1-(8-methylaminooctyl)pyrrolidin-3-yl]-2,2-diphenylacetamide or a solvate thereof. This invention also provides pharmaceutical compositions comprising the salt or prepared using the salt; processes and intermediates for preparing the salt; and methods of using the salt to treat a pulmonary disorder.

US Patent:

7728004, Jun 1, 2010

Filed:

Apr 5, 2006

Appl. No.:

11/398119

Inventors:

Paul R. Fatheree - San Francisco CA, US
S. Derek Turner - San Francisco CA, US
Adam A. Goldblum - San Francisco CA, US
Robert S. Chao - Santa Clara CA, US
Daniel Genov - San Francisco CA, US

Assignee:

Theravance, Inc. - South San Francisco CA

International Classification:

A61K 31/46
C07D 451/02

US Classification:

514304, 546126

Abstract:

The invention provides a crystalline hydrochloride salt of 1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid {(1S,3R,5R)-8-[(R)-2-hydroxy-3-(methanesulfonyl-methyl-amino)propyl]-8-azabicyclo[3. 2. 1]oct-3-yl}amide or a solvate thereof. The invention also provides pharmaceutical compositions comprising such crystalline salt forms, methods of using such crystalline salt forms to treat diseases associated with 5-HTreceptor activity, and processes useful for preparing such crystalline salt forms.

US Patent:

7855221, Dec 21, 2010

Filed:

Sep 29, 2009

Appl. No.:

12/569058

Inventors:

Robert S. Chao - Santa Clara CA, US
Weijiang Zhang - Concord CA, US

Assignee:

Theravance, Inc. - South San Francisco CA

International Classification:

A61K 31/415
C07D 233/54

US Classification:

514398, 5483255

Abstract:

The invention provides a crystalline freebase form of 4′-{2-ethoxy-4-ethyl-5-[((S)-2-mercapto-4-methylpentanoylamino)methyl]imidazol-1-ylmethyl}-3′-fluorobiphenyl-2-carboxylic acid. This invention also provides pharmaceutical compositions comprising the crystalline compound, processes and intermediates for preparing the crystalline compound, and methods of using the crystalline compound to treat diseases such as hypertension.

US Patent:

7880010, Feb 1, 2011

Filed:

Apr 24, 2007

Appl. No.:

11/789154

Inventors:

Jennifer Bolton - Edinburgh, GB
Robert S. Chao - Santa Clara CA, US
Miroslav Rapta - Sunnyvale CA, US
Lisa Williams - Santa Clara CA, US
Richard D. Wilson - El Sobrante CA, US

Assignee:

Theravance, Inc. - South San Francisco CA

International Classification:

C07D 211/46
A61K 31/445

US Classification:

546222, 514327

Abstract:

The invention relates to crystalline free base forms of biphenyl-2-ylcarbamic acid 1-[2-(4-{[(R)-2-(3-formylamino-4-hydroxyphenyl)-2-hydroxyethylamino]methyl}-2,5-dimethylphenylcarbamoyl)ethyl]piperidin-4-yl ester or a solvate thereof. This invention also relates to pharmaceutical compositions containing or prepared from such crystalline forms; processes and intermediates useful for preparing such crystalline forms; and methods of using such crystalline forms to, for example, treat a pulmonary disorder.

US Patent:

8101766, Jan 24, 2012

Filed:

Feb 11, 2009

Appl. No.:

12/369605

Inventors:

Robert S. Chao - Santa Clara CA, US
Miroslav Rapta - Sunnyvale CA, US
Pierre-Jean Colson - San Francisco CA, US

Assignee:

Theravance, Inc. - South San Francisco CA

International Classification:

C07D 215/38

US Classification:

546156, 546135

Abstract:

The invention provides a crystalline 1,2-ethanedisulfonic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-5-methoxyphenylcarbamoyl)ethyl]piperidin-4-yl ester or a solvate thereof. This invention also provides pharmaceutical compositions comprising such a salt or prepared using such a salt; processes and intermediates for preparing such a salt; and methods of using such a salt to treat a pulmonary disorder.