Robert L Holton

US Patent:

7358378, Apr 15, 2008

Filed:

Jun 8, 2006

Appl. No.:

11/449075

Inventors:

Phong Vu - Little Falls NJ, US
Robert A. Holton - Tallahassee FL, US

Assignee:

Florida State University Research Foundation, Inc. - Tallahassee FL

International Classification:

C07D 305/12

US Classification:

549510

Abstract:

The present invention provides processes for the production of paclitaxel. Paclitaxel is produced by protecting the C(7) and the C(10) hydroxy groups of 10-DAB with a bridging silicon-based protecting group. The resulting 7,10-protected 10-DAB derivative is then derivatized and deprotected to form paclitaxel.

US Patent:

7541458, Jun 2, 2009

Filed:

Jun 8, 2006

Appl. No.:

11/449462

Inventors:

Phong Vu - Little Falls NJ, US
Robert A. Holton - Tallahassee FL, US

Assignee:

Florida State University Research Foundation, Inc. - Tallahassee FL

International Classification:

C07D 205/08

US Classification:

540200

Abstract:

The present invention is directed to a process for the preparation of β-lactams. Generally, an imine is cyclocondensed with a ketene acetal or enolate to form the β-lactam product in a “one pot” synthesis, this process is generally performed at a higher temperature than conventional processes.

US Patent:

7550608, Jun 23, 2009

Filed:

Jun 8, 2006

Appl. No.:

11/449048

Inventors:

Phong Vu - Little Falls NJ, US
Robert A. Holton - Tallahassee FL, US

Assignee:

Florida State University Research Foundation, Inc. - Tallahassee FL

International Classification:

C07D 305/00
C07D 407/00

US Classification:

549510, 549511, 549214

Abstract:

The present invention provides processes for the production of docetaxel. Docetaxel is produced by protecting the C(7) and the C(10) hydroxy groups of 10-DAB with a bridging silicon-based protecting group. The resulting 7,10-protected 10-DAB derivative is then derivatized and deprotected to form docetaxel.

US Patent:

7667055, Feb 23, 2010

Filed:

Jun 8, 2006

Appl. No.:

11/449535

Inventors:

Phong Vu - Little Falls NJ, US
Robert A. Holton - Tallahassee FL, US

Assignee:

Florida State University Research Foundation, Inc. - Tallahassee FL

International Classification:

C07D 407/00

US Classification:

549510, 549511

Abstract:

The present invention provides processes for the production of polycyclic fused ring compounds. The polycyclic fused ring compounds are produced by protecting a polycyclic fused ring polyol with a bridging silicon-based protecting group and attaching a suitable side chain. Polycyclic fused ring compounds and intermediate compounds are also described.

US Patent:

20060281918, Dec 14, 2006

Filed:

Jun 8, 2006

Appl. No.:

11/449045

Inventors:

Phong Vu - Little Falls NJ, US
Robert Holton - Tallahassee FL, US

Assignee:

Florida State University Research Foundation, Inc. - Tallahassee FL

International Classification:

C07D 205/08

US Classification:

540354000

Abstract:

A new process for resolution of an enantiomeric mixture of C3-hydroxyl substituted β-lactams is disclosed. Generally, the enantiomeric mixture is treated with an optically active proline acylating agent to form a C3-ester substituted β-lactam diastereomer or a mixture of C3-ester substituted β-lactam diastereomers followed by selective recovery of the unreacted enantiomer or of one of the diastereomers.

US Patent:

41436962, Mar 13, 1979

Filed:

Aug 8, 1977

Appl. No.:

5/822487

Inventors:

Robert J. Holton - North Caldwell NJ
James F. Waterson - Cranford NJ

Assignee:

Eaton Corp. - Cleveland OH

International Classification:

H02G 314
F16B 3702

US Classification:

151 4175

Abstract:

An improved self-retaining fastener which allows non-rotational, longitudinal insertion of an externally threaded fastener and prevents non-rotational, longitudinal removal thereof. The improved fastener includes antirotation means adapted for frontal insertion into a mounting structure, means for self-locking upon insertion into the mounting structure, and means for enhancing the locking frictional force imposed on the externally threaded fastener.

US Patent:

43854311, May 31, 1983

Filed:

Jul 9, 1981

Appl. No.:

6/288277

Inventors:

Robert J. Holton - North Caldwell NJ

Assignee:

Eaton Corporation - Cleveland OH

International Classification:

B23P 1902

US Classification:

29525

Abstract:

An improved, thin walled fastener for retaining studs, rods, or the like is provided. The fastener is of the push-on type comprising a one-piece, generally thin, stamped sheet metal resilient body defining a generally centrally located stud retaining aperture for receipt and retention of studs, rods or the like. The body is preferably generally frusto-conical or dome shaped in cross section. The fastener is formed by punching or shearing a hole in a blank and then forming a generally dome shaped impression in the blank, the impression being generally coaxial with the axis of the punched hole. The required transverse extensions of the body are minimized by the utilization of the relatively smooth continuous edge of the punched hole rather than the burred edge of a punched hole as the stud retaining edge of the fastener stud retaining aperture.

US Patent:

42597676, Apr 7, 1981

Filed:

Jul 9, 1979

Appl. No.:

6/055740

Inventors:

Robert J. Holton - North Caldwell NJ

Assignee:

Eaton Corporation - Cleveland OH

International Classification:

F16B 220

US Classification:

24 73SM

Abstract:

A one-piece, spring steel fastener (10) for releasably retaining the edge of a plastic panel (P) with a predetermined resistance to release is provided. The fastener comprises a base section (12) and a pair of leg sections (14, 16) extending therefrom. The leg sections each comprise a first portion (22, 24) extending upwardly and inwardly from the base section and a second portion (34, 36) extending downwardly and inwardly from the first portion to a free edge (38, 40). A tab (46, 48) is sheared from the second leg portions and extends generally inwardly therefrom. The free edges are separated by a distance (42) generally equal to the thickness (44) of the panel while the innermost edges of the tabs are separated by a distance (50) less than the thickness of the panel.