Robert M Mcnally

US Patent:

52193284, Jun 15, 1993

Filed:

Jan 3, 1990

Appl. No.:

7/460379

Inventors:

Brenda S. Morse - Chamblee GA
A. Denise Turner - Dunwoody GA
Robert T. McNally - Marietta GA

Assignee:

CryoLife, Inc. - Marietta GA

International Classification:

A61M 3100
A61M 3500

US Classification:

604 49

Abstract:

The present invention relates to a method for the formulation of fibrin sealant in a single delivery system. The method involves mixing a fibrinogen/Factor XIII precipitate solution with thrombin under conditions such that thrombin clotting activity is inhibited and said mixture is applied to a body site under conditions which activate the thrombin to convert fibrinogen into fibrin sealant. A single device, syringe or container, can be used to apply the fibrin sealant formulation.

US Patent:

48904570, Jan 2, 1990

Filed:

Jan 2, 1987

Appl. No.:

7/000095

Inventors:

Robert T. McNally - Marietta GA
Albert Heacox - Marietta GA
Kelvin G. M. Brockbank - Marietta GA
Harvey L. Bank - Charleston SC

Assignee:

CryoLife, Inc. - Atlanta GA

International Classification:

F25D 1304

US Classification:

62 65

Abstract:

A method of freezing, storing and thawing collagen-rich tissue, such as heart valves. The method includes a freezing profile for freezing the tissue down to the temperature of liquid nitrogen with minimal tissue damage due to ice crystal formation. Heart valves cryopreserved according to the present process exhibit a high cell viability when thawed and are suitable for implanting in human patients.

US Patent:

51588676, Oct 27, 1992

Filed:

Jan 23, 1990

Appl. No.:

7/436365

Inventors:

Robert T. McNally - Marietta GA
Cameron McCaa - Marietta GA
Kelvin G. M. Brockbank - Marietta GA
Albert E. Heacox - Marietta GA
Harvey L. Bank - Charleston SC

Assignee:

CryoLife Inc. - Marietta GA
Medical Univ. of South Carolina - Marietta GA

International Classification:

A01N 102

US Classification:

435 1

Abstract:

A device for use in cryopreservation of blood vessels comprising a pair of stylets insertable into the ends of a dissected blood vessel segment. The stylets are mountable on a support track whereby the blood vessel can be distended and supported during cryopreservation procedures. Also disclosed is a freezing and thawing profile capable of maximizing endothelial cell survival. The use of chondroitin sulfate or similar compound is discussed as a novel cryoprotectant.

US Patent:

51221101, Jun 16, 1992

Filed:

Jan 23, 1990

Appl. No.:

7/436357

Inventors:

Robert T. McNally - Marietta GA
Cameron McCaa - Marietta GA
Kelvin G. M. Brockbank - Marietta GA
Albert E. Heacox - Marietta GA
Harvey L. Bank - Charleston SC

Assignee:

CryoLife, Inc. - Marietta GA
Medical Univ. of South Carolina - Marietta GA

International Classification:

A61F 204
A61B 1900

US Classification:

600 36

Abstract:

A device for use in cryopreservation of blood vessels comprising a pair of stylets insertable into the ends of a dissected blood vessel segment. The stylets are mountable on a support track whereby the blood vessel can be distended and supported during cryopreservation procedures. Also disclosed is a freezing and thawing profile capable of maximizing endothelial cell survival. The use of chondroitin sulfate or similar compound is discussed as a novel cryoprotectant.

US Patent:

53185242, Jun 7, 1994

Filed:

Mar 2, 1992

Appl. No.:

7/844497

Inventors:

Brenda S. Morse - Chamblee GA
A. Denise Turner - Dunwoody GA
Robert T. McNally - Marietta GA

Assignee:

CryoLife, Inc. - Marietta GA

International Classification:

A61M 3700

US Classification:

604 82

Abstract:

The present invention relates to a method for the formulation of fibrin sealant in a single delivery system. The method involves mixing a fibrinogen/Factor XIII precipitate solution with thrombin under conditions such that thrombin clotting activity is inhibited and said mixture is applied to a body site under conditions which activate the thrombin to convert fibrinogen into fibrin sealant. A single device, syringe or container, can be used to apply the fibrin sealant formulation.

US Patent:

51496216, Sep 22, 1992

Filed:

Jan 23, 1990

Appl. No.:

7/436364

Inventors:

Robert T. McNally - Marietta GA
Cameron McCaa - Marietta GA
Kelvin G. M. Brockbank - Marietta GA
Albert E. Heacox - Marietta GA
Harvey L. Bank - Charleston SC

Assignee:

CryoLife, Inc. & Medical Univ. of South Carolina - Marietta GA

International Classification:

A01N 102

US Classification:

435 1

Abstract:

A device for use in cryopreservation of blood vessels comprising a pair of stylets insertable into the ends of a dissected blood vessel segment. The stylets are mountable on a support track whereby the blood vessel can be distended and supported during cryopreservation procedures. Also disclosed is a freezing and thawing profile capable of maximizing endothelial cell survival. The use of chondroitin sulfate or similar compound is discussed as a novel cryoprotectant and DMSO is disclosed as a penetrating cyroprotectant.

US Patent:

51457695, Sep 8, 1992

Filed:

Aug 21, 1987

Appl. No.:

7/088092

Inventors:

Robert T. McNally - Marietta GA
Cameron McCaa - Marietta GA
Kelvin G. M. Brockbank - Marietta GA
Albert E. Heacox - Marietta GA
Harvey L. Bank - Charleston SC

Assignee:

CryoLife Inc. - Marietta GA
Medical Univ. of South Carolina - Marietta GA

International Classification:

A01N 102

US Classification:

435 1

Abstract:

A device for use in cryopreservation of blood vessels comprising a pair of styles insertable into the ends of a dissected blood vessel segment. The styles are mountable on a support track whereby the blood vessel can be distended and supported during cryopreservation procedures. Also disclosed is a freezing and thawing profile capable of maximizing endothelial cell survival. The use of chondroitin sulfate or similar compound is discussed as a novel cryoprotectant.