Robin D Zimmer

US Patent:

20230049988, Feb 16, 2023

Filed:

Apr 29, 2021

Appl. No.:

17/612238

Inventors:

- New York NY, US
Atilio Anzellotti - Oak Ridge TN, US
Nancy Tommye Jordan - Knoxville TN, US
Boyce Lee Muller - Knoxville TN, US
Robin D. Zimmer - Loudon TN, US
Adam Michael Cable - Lenoir City TN, US

Assignee:

DAXOR CORP. - New York NY

International Classification:

A61K 49/00

Abstract:

Pharmaceutical compositions and methods are presented for creating a ternary structure involving a fluorescent molecule, an intermediate carrier molecule, and a larger protein or polymer with a binding site receptive to the intermediate molecule or fluorescent/intermediate complex. The resulting ternary system improves the binding stability of the fluorescent dye to the protein, both in-vivo and in-vitro. This improved stability results in a longer half-life in medical use, enabling improved qualitative and quantitative use of the dye.