Several AstraZenca Excellence awards for delivering workshops such as: a roller compaction (including modeling) workshop in April 2008 and a leadership capabilities workshop in June 2008, • Ondetti and Cushman Innovation Award (November 2003) for discovery of a novel platform technology for orally disintegrating tablets. This is the highest level discovery award at Bristol-Myers Squibb that honors work that can make a significant scientific and economic impact for Bristol-Myers Squibb. • Five Bristol-Myers Squibb Star Awards for collaborative work, driving performance and direct communication on several high-priority projects. • Bristol-Myers Squibb-Excellence Award for the year 2000.
Joseph Richard Creekmore - Wilmington DE, US Sanjeev Hukmichand Kothari - Wilmington DE, US Bradford J. Mueller - Wilmington DE, US Yingxu Peng - Wilmington DE, US
Assignee:
AstraZeneca UK Limited - London
International Classification:
A61K 9/32 A61K 31/505 A61K 9/36
US Classification:
424480, 424494, 424497, 514275
Abstract:
The invention relates to pharmaceutical compositions containing rosuvastatin calcium of formula (I) and processes for their manufacture.
Sanjeev Kothari - Princeton NJ, US Divyakant Desai - West Windsor NJ, US
International Classification:
A61K009/14 A61K009/20 A61K031/47 A61K031/225
US Classification:
424/465000, 514/019000, 514/312000, 514/547000
Abstract:
There is provided granules for the production of flash-melt pharmaceutical oral dosage forms. In addition to one or more medicaments, the granules are composed of an excipient combination consisting of a superdisintegrant, a dispersing agent, a distributing agent, and a binder and may also include other conventional ingredients such as sweetening and flavoring agents. The subject granules are advantageous in that they are stable and can be prepared without the aid of solvents and without the need for special environments or handling. Dosage forms, especially tablets, prepared therefrom on conventional equipment disintegrate in the mouth in under about twenty five seconds.
Omar Sprockel - Bridgewater NJ, US Chiajen Lai - Kendall Park NJ, US Robert Discordia - Pennington NJ, US Chenkou Wei - Prnceton Junction NJ, US Sanjeev Kothari - Princeton NJ, US Soojin Kim - West Orange NJ, US
International Classification:
A61K009/20
US Classification:
424/465000
Abstract:
The invention is directed toward a method for increasing the compactability of an active ingredient by determining the crystallization parameters of the active ingredient that affect compactability; and controlling the crystallization parameters to achieve increased compactability.
Omar Sprockel - Bridgewater NJ, US Chiajen Lai - Kendall Park NJ, US Chenkou Wei - Princeton Junction NJ, US Sanjeev Kothari - Princeton NJ, US Robert Discordia - Pennington NJ, US Soojin Kim - West Orange NJ, US
Divyakant Desai - West Windsor NJ, US Sanjeev Kothari - Princeton NJ, US Laxmikant Sharma - Indianapolis IN, US
International Classification:
A61K 31/522 A61K 9/22 A61K 31/16 A61K 31/175
US Classification:
424468000, 514263340, 514592000, 514629000
Abstract:
The present invention relates to a pharmaceutical delivery system comprising a gel-like structure that comprises at least one water-soluble polymer, such as, for example, povidone or hydroxypropyl cellulose, and at least one fatty acid, such as, for example, stearic acid or lauric acid. The invention further relates to a sustained release drug delivery composition comprising the gel-like structure and at least one drug trapped or dissolved therein, wherein said system is capable of releasing the drug in a dissolution medium at a controlled rate. The invention is also directed to a method for preparing the sustained release drug delivery composition.
There is provided granules for the production of flash-melt pharmaceutical oral dosage forms. In addition to one or more medicaments, the granules are composed of an excipient combination consisting of a superdisintegrant, a dispersing agent, a distributing agent, and a binder and may also include other conventional ingredients such as sweetening and flavoring agents. The subject granules are advantageous in that they are stable and can be prepared without the aid of solvents and without the need for special environments or handling. Dosage forms, especially tablets, prepared therefrom on conventional equipment disintegrate in the mouth in under about twenty five seconds.
SANJEEV KOTHARI - Princeton NJ, US DIVYAKANT S. DESAI - West Windsor NJ, US
International Classification:
A61K 47/00
US Classification:
514770
Abstract:
There is provided granules for the production of flash-melt pharmaceutical oral dosage forms. In addition to one or more medicaments, the granules are composed of an excipient combination consisting of a superdisintegrant, a dispersing agent, a distributing agent, and a binder and may also include other conventional ingredients such as sweetening and flavoring agents. The subject granules are advantageous in that they are stable and can be prepared without the aid of solvents and without the need for special environments or handling. Dosage forms, especially tablets, prepared therefrom on conventional equipment disintegrate in the mouth in under about twenty five seconds.
Sanjeev Kothari - Princeton NJ, US Divyakant Desai - West Windsor NJ, US
International Classification:
A61K 9/00 A61K 31/496
US Classification:
424400, 51425307
Abstract:
There is provided granules for the production of flash-melt pharmaceutical oral dosage forms. In addition to one or more medicaments, the granules are composed of an excipient combination consisting of a superdisintegrant, a dispersing agent, a distributing agent, and a binder and may also include other conventional ingredients such as sweetening and flavoring agents. The subject granules are advantageous in that they are stable and can be prepared without the aid of solvents and without the need for special environments or handling. Dosage forms, especially tablets, prepared therefrom on conventional equipment disintegrate in the mouth in under about twenty five seconds.
Genentech since Sep 2010
Senior Scientific Manager
AAPS MSE Subgroup 2009 - 2010
Committee Member
AstraZeneca Oct 2007 - Sep 2010
Team Manager, Product Development (Material Science and Process Engineering)
BMS 1998 - 2007
Senior Research Investigator
Bristol-Myers Squibb (New Brunswick, NJ) 1998 - 2007
Research Investigator I and II; Senior Research Investigator I and II
Education:
University of Iowa 1993 - 1998
Ph.D., Pharmaceutics
University of Pune 1986 - 1990
B.Pharm, Pharmacy
St. Vincents
Honor & Awards:
• Several AstraZenca Excellence awards for delivering workshops such as: a roller compaction (including modeling) workshop in April 2008 and a leadership capabilities workshop in June 2008,
• Ondetti and Cushman Innovation Award (November 2003) for discovery of a novel platform technology for orally disintegrating tablets. This is the highest level discovery award at Bristol-Myers Squibb that honors work that can make a significant scientific and economic impact for Bristol-Myers Squibb.
• Five Bristol-Myers Squibb Star Awards for collaborative work, driving performance and direct communication on several high-priority projects.
• Bristol-Myers Squibb-Excellence Award for the year 2000.
Youtube
Sanjeev Kothari - Message for Youth
Sanjeev Kothari, Director, Orion EduTech. Hunar Hai To Kadar Hai. Visi...