Shi Jeng Huang

US Patent:

6974589, Dec 13, 2005

Filed:

Oct 10, 2000

Appl. No.:

09/685940

Inventors:

Shi Kun Huang - Castro Valley CA, US
Samuel Zalipsky - Redwood City CA, US
Wei-Ming Zhang - San Francisco CA, US
Bei Jin - Union City CA, US
Yolanda P. Quinn - Daly City CA, US

Assignee:

Miza Corporation - Mountain View CA

International Classification:

A61K009/127

US Classification:

424450, 424 121, 424 9321, 424 951, 424417, 4284022

Abstract:

A lipid represented by the formula: wherein each of Rand Ris an alkyl or alkenyl chain having between about 8 to about 24 carbon atoms; n=0–20; L is selected from the group consisting of (i) —X—(C═O)—Y—, (ii) —X—(C═O)—, and (iii) —X—CH—, wherein X and Y are independently selected from oxygen, NH, and a direct bond; and Z is a weakly basic moiety that has a pK of less than about 7. 4 and greater than about 4. 0 is described.

US Patent:

7108863, Sep 19, 2006

Filed:

Mar 26, 2002

Appl. No.:

10/108154

Inventors:

Samuel Zalipsky - Redwood City CA, US
Theresa M. Allen - Edmonton, CA
Shi Kun Huang - Castro Valley CA, US

Assignee:

Alza Corporation - Mountain View CA

International Classification:

A61B 5/055
A61B 8/00
A61K 9/127

US Classification:

424450, 424 9321, 424 951

Abstract:

A liposomal composition and a method of using the same for achieving intracellular delivery of a liposome-entrapped agent is described. The liposomes are composed of a pH sensitive lipid and include a targeting ligand to direct the liposomes to a target cell. The liposomes also include a stabilizing component, such a polymer-derivatized lipid, where the polymer is attached to the lipid by a releasable linkage. Administration of the liposomes results in cellular internalization and destabilization of the liposome for intracellular delivery of the entrapped agent.

US Patent:

20050260261, Nov 24, 2005

Filed:

May 19, 2005

Appl. No.:

11/133879

Inventors:

Shi Huang - Castro Valley CA, US
Samuel Zalipsky - Redwood City CA, US
Wei-Ming Zhang - San Francisco CA, US
Bei Jin - Union City CA, US
Yolanda Quinn - Daly City CA, US

International Classification:

C07D233/54
A61K009/127

US Classification:

424450000, 548338100

Abstract:

A lipid represented by the formula: wherein each of Rand Ris an alkyl or alkenyl chain having between about 8 to about 24 carbon atoms; n=0-20; L is selected from the group consisting of (i) —X—(C═O)—Y—, (ii) —X—(C═O)—, and (iii) —X—CH—, wherein X and Y are independently selected from oxygen, NH and a direct bond; and Z is a weakly basic moiety that has a pK of less than about 7.4 and greater than about 4.0 is described.

US Patent:

20060240009, Oct 26, 2006

Filed:

Jun 20, 2006

Appl. No.:

11/472140

Inventors:

Samuel Zalipsky - Redwood City CA, US
Theresa Allen - Edmonton, CA
Shi Huang - Castro Valley CA, US

International Classification:

A61K 39/395
A61K 9/127

US Classification:

424144100, 424450000

Abstract:

A liposomal composition and a method of using the same for achieving intracellular delivery of a liposome-entrapped agent is described. The liposomes are composed of a pH sensitive lipid and include a targeting ligand to direct the liposomes to a target cell. The liposomes also include a stabilizing component, such a polymer-derivatized lipid, where the polymer is attached to the lipid by a releasable linkage. Administration of the liposomes results in cellular internalization and destabilization of the liposome for intracellular delivery of the entrapped agent.

US Patent:

58518185, Dec 22, 1998

Filed:

Mar 28, 1997

Appl. No.:

8/827236

Inventors:

Shi Kun Huang - Castro Valley CA
Edwin Kiyoshi Oto - Redwood City CA
Mohammad Hassanipour - Vallejo CA
Bei Jin - Union City CA

Assignee:

Sequus Pharmaceuticals, Inc. - Menlo Park CA

International Classification:

C12N 1564
A01N 2526
B01J 1302
C12P 2102

US Classification:

4353201

Abstract:

An improvement in a method of preparing plasmid-liposome complexes for in vivo transfection is described. The improvement includes selecting a condensing agent to condense the plasmid prior to contact with the liposomes, selecting a working medium and selecting a ratio of liposome lipid to plasmid. Also disclosed are DNA plasmid-liposome complexes formed by the method.

US Patent:

53566335, Oct 18, 1994

Filed:

Oct 7, 1992

Appl. No.:

7/958100

Inventors:

Martin C. Woodle - Menlo Park CA
Francis J. Martin - San Francisco CA
Shi K. Huang - Castro Valley CA

Assignee:

Liposome Technology, Inc. - Menlo Park CA

International Classification:

A61K 9127
A61K 3722

US Classification:

424450

Abstract:

A method of and composition for concentrating a therapeutic agent in an inflamed dermal region are disclosed. The composition, which is also used in the method, is a liposomal composition. The liposomes contain the therapeutic agent in entrapped form and are composed of vesicle-forming lipids including a vesicle-forming lipid derivatized with hydrophilic biocompatible polymer. After intravenous administration, the liposomes are taken up by the inflamed region within 24-48 hours, for site-specific release of entrapped compound into the inflamed region.

US Patent:

61330264, Oct 17, 2000

Filed:

Sep 11, 1998

Appl. No.:

9/151436

Inventors:

Shi Kun Huang - Castro Valley CA
Edwin Kiyoshi Oto - Redwood City CA
Mohammad Hassanipour - Vallejo CA
Bei Jin - Union City CA

Assignee:

Sequus Pharmaceuticals, Inc. - Menlo Park CA

International Classification:

C12N 1563
A01N 2526
C07H 2104
C12P 2102

US Classification:

4353201

Abstract:

A plasmid-liposome composition for transfection of a cell is described. The composition includes plasmid molecules condensed with a polycationic condensing agent and cationic liposomes. Also disclosed is a method for preparing the plasmid-liposome complexes.