Stephen E Mercer

US Patent:

6620823, Sep 16, 2003

Filed:

Jul 10, 2001

Appl. No.:

09/901937

Inventors:

Thomas P Maduskuie - Wilmington DE
Jingwu Duan - Newark DE
Stephen E Mercer - Greenville DE

Assignee:

Bristol-Myers Squibb Pharme Company - Princeton NJ

International Classification:

C07D40300

US Classification:

514314, 514326, 514422, 540480, 546176, 546208, 548517, 548518, 548527

Abstract:

The present application describes novel lactams and derivatives thereof of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 4-8 membered cyclic amide comprising 0-3 additional heteroatoms selected from N, O, and S, which are useful as metalloprotease inhibitors.

US Patent:

7125870, Oct 24, 2006

Filed:

Oct 30, 2003

Appl. No.:

10/697545

Inventors:

Thomas P. Maduskuie - Wilmington DE, US
Stephen E. Mercer - Middletown CT, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A01N 47/40

US Classification:

5142352, 51425307, 514307, 514339, 514378, 544 60, 544128, 544363, 546175, 548240

Abstract:

The present application describes novel isoxazoline of formula I or II:.

US Patent:

7384930, Jun 10, 2008

Filed:

Oct 11, 2005

Appl. No.:

11/247697

Inventors:

Prasad V. Chaturvedula - Cheshire CT, US
Stephen E. Mercer - Middletown CT, US
Haiquan Fang - Madison CT, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D 487/04
C07D 401/14
C07D 519/00
A61P 25/06
A61K 31/55

US Classification:

51421206, 540521

Abstract:

The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.

US Patent:

7384931, Jun 10, 2008

Filed:

May 3, 2006

Appl. No.:

11/417326

Inventors:

Prasad V. Chaturvedula - Cheshire CT, US
Stephen E. Mercer - Middletown CT, US
Haiquan Fang - Madison CT, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D 487/04
C07D 401/14
C07D 519/00
A61K 31/55
A61P 25/06

US Classification:

51421206, 540521

Abstract:

The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.

US Patent:

7470679, Dec 30, 2008

Filed:

May 1, 2007

Appl. No.:

11/742615

Inventors:

Stephen E. Mercer - Middletown CT, US
Prasad V. Chaturvedula - Cheshire CT, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D 487/04
C07D 401/14
C07D 519/00
A61K 31/55
A61P 25/06

US Classification:

51421206, 540521

Abstract:

The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.

US Patent:

7470680, Dec 30, 2008

Filed:

May 1, 2007

Appl. No.:

11/742626

Inventors:

Prasad V. Chaturvedula - Cheshire CT, US
Stephen E. Mercer - Middletown CT, US
Haiquan Fang - Madison CT, US
Xiaojun Han - Cheshire CT, US
Guanglin Luo - Madison CT, US
Gene M. Dubowchik - Middlefield CT, US
Graham S. Poindexter - Old Saybrook CT, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D 487/04
C07D 401/14
C07D 519/00
A61K 31/55
A61P 25/06

US Classification:

51421206, 540521

Abstract:

The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.

US Patent:

7544680, Jun 9, 2009

Filed:

Apr 18, 2008

Appl. No.:

12/105434

Inventors:

Prasad V. Chaturvedula - Cheshire CT, US
Stephen E. Mercer - Middletown CT, US
Haiquan Fang - Madison CT, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D 487/00
C07D 491/00
A61K 31/55
A61P 25/06

US Classification:

51421207, 540523

Abstract:

The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.

US Patent:

7772244, Aug 10, 2010

Filed:

Mar 28, 2005

Appl. No.:

11/091429

Inventors:

Andrew P. Degnan - New Haven CT, US
Xiaojun Han - Cheshire CT, US
Gene M. Dubowchik - Middlefield CT, US
John E. Macor - Guilford CT, US
Stephen E. Mercer - Middletown CT, US

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31/517
A61K 31/47
C07D 215/227
C07D 239/80

US Classification:

51426622, 514312, 544286, 546157

Abstract:

The present invention relates to compounds of Formula (I).