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Takeo Iwamoto

age ~66

from Davis, CA

Takeo Iwamoto Phones & Addresses

  • Davis, CA
  • 3705 Katherine Cir, Manhattan, KS 66503 • (785)5398242

Work

  • Position:
    Service Occupations

Education

  • Degree:
    Graduate or professional degree

Us Patents

  • M2Glyr Derived Channel Forming Peptides

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  • US Patent:
    6750200, Jun 15, 2004
  • Filed:
    Nov 9, 2000
  • Appl. No.:
    09/710419
  • Inventors:
    John M. Tomich - Manhattan KS
    Takeo Iwamoto - Manhattan KS
    James R. Broughman - Manhattan KS
    Bruce D. Schultz - Wamego KS
  • Assignee:
    Kansas State University Research Foundation - Manhattan KS
  • International Classification:
    C12Q 100
  • US Classification:
    514 13, 530300, 530326, 435 4, 435325, 436151, 514 14
  • Abstract:
    The present invention provides a family of peptides based upon the M2GlyR sequence. These peptides are derivatives of the M2GlyR sequence and can be modified at their ends to include a plurality of polar amino acid residues to enhance their solubility. Particularly preferred derivatives include portions of the M2GlyR sequence which are palindromic to another portion of the peptide or to the M2GlyR sequence itself. Preferably these portions are at least 7 amino acid residues in length. Peptides embraced by the present invention are characterized by having greater effects on the transepithelial electrical resistance of cells at lower concentrations. Peptides of the present invention have been shown to increase Isc in MDCK epithelial cell monolayers with half maximal effects observed at or below 30 M, a nearly 10-fold improvement over any peptide previously characterized in the M2GlyR family.
  • Peptide-Enhanced Corneal Drug Delivery

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  • US Patent:
    7592341, Sep 22, 2009
  • Filed:
    Dec 15, 2005
  • Appl. No.:
    11/304929
  • Inventors:
    John M. Tomich - Manhattan KS, US
    Takeo Iwamoto - Manhattan KS, US
  • Assignee:
    Kansas State University Research Foundation - Manhattan KS
  • International Classification:
    A61K 47/16
  • US Classification:
    514249, 5147723, 514773
  • Abstract:
    Improved methods and preparations are provided for ocular administration of therapeutic drugs. The preparations include respective quantities of a drug and a peptide which enhances transport of the drug across ocular tissues. The drug and peptide components may be separately administered or used as a mixture. The preferred peptide is NC-1059 (SEQ. ID NO. 1).
  • Ph Dependent Adhesive Peptides

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  • US Patent:
    7745570, Jun 29, 2010
  • Filed:
    Dec 16, 2005
  • Appl. No.:
    11/793187
  • Inventors:
    John Tomich - Manhattan KS, US
    Takeo Iwamoto - Manhattan KS, US
    Xinchun Shen - Chapel Hill NC, US
    Xiuzhi Susan Sun - Manhattan KS, US
  • Assignee:
    Kansas State University Research Foundation - Manhattan KS
  • International Classification:
    C07K 7/00
    C07K 14/00
  • US Classification:
    530300
  • Abstract:
    A novel peptide adhesive motif is described that requires no receptor or cross-links to achieve maximal adhesive strength. Several peptides with different degrees of adhesive strength have been designed and synthesized using solid phase chemistries. All peptides contain a common hydrophobic core sequence flanked by positively or negatively charged amino acids sequences.
  • Branched Amphipathic Oligo-Peptides That Self-Assemble Into Vesicles

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  • US Patent:
    20120021020, Jan 26, 2012
  • Filed:
    Mar 26, 2010
  • Appl. No.:
    13/259771
  • Inventors:
    John M. Tomich - Manhattan KS, US
    Takeo Iwamoto - Manhattan KS, US
    Yasuaki Hiromasa - Manhattan KS, US
    Sushanth Gudlur - Manhattan KS, US
  • Assignee:
    KANSAS STATE UNIVERSITY RESEARCH FOUNDATION - Manhattan KS
  • International Classification:
    A61K 9/00
    A61K 38/16
    A61K 38/43
    A61K 51/12
    A61K 31/7088
    A61K 38/10
    A61K 47/42
  • US Classification:
    424400, 530327, 530326, 530325, 530324, 514773, 424 121, 514 44 R, 424 941
  • Abstract:
    The present invention provides branched amphipathic peptides and vesicles formed thereof. The peptides comprise a polar/positively charged C-terminal segment, a branch point, and two hydrophobic N -terminal segments extending from the branch point. The vesicles are formed using a plurality of first and second peptides, wherein the first peptide has a different chain length from the second peptide. When a plurality of the first and second peptides are mixed together, they self-assemble to form small spheres defined by a membrane consisting of an interlocking peptide network bilayer and having a liquid-receiving interior space (i.e., hollow core). In the bi-layer, the respective hydrophobic segments of the peptides form beta-sheet structures having a hydrogen bond-stabilized, anti-parallel orientation in which the opposed sequences interlock to form a zipper-like structure in three dimensions. Thus, the peptide assembly (i.e., vesicle) can be held together at reduced concentrations where lipid vesicles would breakdown.
  • Methods For Purifying Synthetic Peptides

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  • US Patent:
    59228407, Jul 13, 1999
  • Filed:
    Jul 23, 1996
  • Appl. No.:
    8/685279
  • Inventors:
    John M. Tomich - Manhattan KS
    Takeo Iwamoto - Manhattan KS
  • Assignee:
    Kansas State University Research Foundation - Manhattan KS
  • International Classification:
    A61K 3804
  • US Classification:
    530344
  • Abstract:
    Methods for making preparations of homogenous peptides are disclosed. In these methods, reversible alterations of the physicochemical properties of the peptides are exploited. In preferred embodiments, the methods include the following sequential steps: (1) exhaustive capping is carried out during solid-phase synthesis of a desired peptide; (2) a cleavable linker is attached to the peptide, (3) a polymer is added to the peptide either by condensation with preformed polymer or by in situ polymerization such that the linker is interposed between the polymer moiety and the peptide moiety of the resultant adduct; alternatively, steps (2) and (3) can be conducted simultaneously by attaching a combination polymer/linker to the peptide; (4) the polymer-peptide adduct is cleaved from the resin; (5) the polymer-peptide adduct is purified from undesired, nonadducted peptides; and (6) the polymer-peptide adduct is cleaved at the linker, and the desired peptide is purified from the polymer. In some cases, it may be desirable to omit step (6) in order to leave the polymer moiety attached to the desired peptide. For example, the polymer-peptide adducts of the present invention are very soluble in water, and therefore can be used to solubilize amphipathic peptides.
  • Synthetic Macromolecular Channel Assembly For Transport Of Chloride Ions Through Epithelium Useful In Treating Cystic Fibrosis

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  • US Patent:
    60778261, Jun 20, 2000
  • Filed:
    Jun 8, 1998
  • Appl. No.:
    9/093227
  • Inventors:
    John M. Tomich - Manhattan KS
    Takeo Iwamoto - Manhattan KS
    Lawrence P. Sullivan - Shawnee KS
  • Assignee:
    Kansas State University Research Foundation - Manhattan KS
  • International Classification:
    C07K 1400
    A61K 3816
  • US Classification:
    514 12
  • Abstract:
    The present invention is directed to multiple-peptide channel assemblies for transport of anions such as chloride ions through epithelial cells, synthetic peptides capable of forming such channel assemblies and methods for using channel assemblies in therapeutic contexts for altering the flux of water across epithelial cells. The channel assemblies are composed of a plurality of peptides that transport through the membrane of an epithelial cell and provide for alteration of the flux of water through the cell. The peptides are soluble in water to a level of at least 10 mM and exhibit at least about 50% helical content when dispersed in a 40% trifluoroethanol/60% water solution. The peptides ideally have the amino acid sequence ABC(X). sub. n DEF, where A, B, C, D, F and X are individual amino acid residues, n ranges from 12-24 and at least one of the amino acids selected from the group consisting of A, B, and C is a charged amino acid, and at least one of the amino acids selected from the group consisting of D, E, and F is a charged amino acid. The method hereof provides for altering flux of water from an epithelial cell and includes providing from 3-6 peptides capable of forming a channel assembly with each of such peptides having from about 18-30 amino acid residues therein, then contacting the peptides with a surface of an epithelial cell to cause the peptides to embed therein and alter the flux of water across the cell.

News

Strong Earthquake Strikes off Northeastern Japan

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  • Immediately following Friday's quake, there were no problems at any of the nuclear plants operated by Fukushima Dai-Ichi operator Tokyo Electric Power Co., said a TEPCO spokesman, Takeo Iwamoto. Only two of Japan's 50 nuclear plants are currently operating; the rest have been shut down for maintenan
  • Date: Dec 08, 2012
  • Category: World
  • Source: Google

Japan's post-quake tsunami warning lifted

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  • , said a TEPCO spokesman, Takeo Iwamoto. Only two of Japan's 50 nuclear plants are currently operating; the rest have been shut down for maintenance and safety checks while the country re-examines the future of nuclear power there.
  • Date: Dec 07, 2012
  • Category: World
  • Source: Google

Typhoon Roke Makes Landfall in Japan; Three People Killed

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  • Several works and operations at the Fukushima Dai-Ichiwere affected due to wind and heavy rain brought by thetyphoon, Takeo Iwamoto, a spokesman at the utility, said bytelephone today. We halted sea-water sampling, sea-watertreatment and works to build water shields.
  • Date: Sep 21, 2011
  • Source: Google

Typhoon Roke Hits Japan on Course for Leaking Nuclear Plant

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  • The company is in the process of installing a cover for theNo. 1 reactor building and aims to put similar covers over units3 and 4 next year after debris is cleared, Tokyo Electricspokesman Takeo Iwamoto said today. The tops of those threeunits were blown off by hydrogen explosions in March.
  • Date: Sep 20, 2011
  • Category: World
  • Source: Google

Typhoon Songda strengthens; may hit Fukushima nuclear station

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  • We are still considering typhoon measures and cant announce detailed plans yet, Takeo Iwamoto, a spokesman at Tokyo Electric Power Co., said by phone when asked about the storm. The utility known as Tepco plans to complete the installation of covers for the buildings by October, he said.
  • Date: May 27, 2011
  • Category: World
  • Source: Google

Fire at another TEPCO nuclear plant in Japan

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  • Takeo Iwamoto, a spokesman for Tokyo Electric Power Co., says a fire broke out Friday at a building at the Fukushima Dai-ichi nuclear plant. The complex is located about 7.5 miles (12 kilometres) south of TEPCOs tsunami-hit Fukushima Dai-ichi nuclear complex.
  • Date: May 26, 2011
  • Category: World
  • Source: Google

UN Opens Probe Into Japan's Crippled Nuke Plant

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  • "We have analyzed data, which showed that it was highly likely that most of the fuel rods have melted. But it is unlikely that melting fuel rods could worsen the crisis because the melted fuels are covered in water," said Takeo Iwamoto, a company spokesman.
  • Date: May 24, 2011
  • Category: World
  • Source: Google

Tepco Must End 'Whack-a-Mole,' Cover Fukushima Reactors as Typhoons Loom

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  • The temporary covers are the only measures planned at themoment to protect against typhoons, Takeo Iwamoto, a Tepcospokesman, said by phone. The company may install them fasterthan the plan announced on April 17, he said.
  • Date: Apr 20, 2011
  • Source: Google

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