Tammy Tan Huang

US Patent:

6594805, Jul 15, 2003

Filed:

Nov 13, 2001

Appl. No.:

09/986912

Inventors:

Alexander Tetelbaum - Hayward CA
Maad A. Al-Dabagh - Sunnyvale CA
Tammy T. Huang - Fremont CA

Assignee:

LSI Logic Corporation - Milpitas CA

International Classification:

G06F 1750

US Classification:

716 5, 716 6, 716 8, 716 1, 716 4, 716 18

Abstract:

A system, method and program for hierarchically designing integrated circuits(ICs). Potential sources of crosstalk are identified in the hierachical design and prior to and during placement and wiring while maintaining the hierachical structure. Blocks are placed and analyzed to determine if all blocks are well behaved and where necessary selectively re-organized to be well behaved. Blockages are inserted blocks to restrict top level wiring to avoid crosstalk. Orthogonal restrictions are placed on top level wiring as well as on top level wire lengths.

US Patent:

8183014, May 22, 2012

Filed:

Sep 12, 2011

Appl. No.:

13/230081

Inventors:

Sean Stevens - San Francisco CA, US
Tammy T. Huang - Goldens Bridge NY, US
Joel H. Martin - Putnam Valley NY, US
Jeanette L. Fairhurst - White Plains NY, US
Ashique Rafique - Yonkers NY, US
Eric Smith - New York NY, US
Kevin J. Pobursky - Beacon NY, US
Nicholas J. Papadopoulos - LaGrangeville NY, US
James P. Fandl - LaGrangeville NY, US
Gang Chen - Yorktown Heights NY, US
Margaret Karow - Santa Rosa Valley CA, US

Assignee:

Regeneron Pharmaceuticals, Inc. - Tarrytown NY

International Classification:

C12N 5/10
C12N 15/13
C12N 15/63

US Classification:

435 696, 4352523, 4353201, 435325, 536 2353

Abstract:

A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a Kof about 500 pM or less and blocks IL-6 activity with an ICof 200 pM or less, is provided. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an affinity at least 2-fold higher relative to its binding monkey IL-6R.

US Patent:

8338135, Dec 25, 2012

Filed:

Dec 2, 2011

Appl. No.:

13/309594

Inventors:

Sean Stevens - San Francisco CA, US
Tammy T. Huang - Goldens Bridge NY, US
Joel H. Martin - Putnam Valley NY, US
Jeanette L. Fairhurst - White Plains NY, US
Ashique Rafique - Yonkers NY, US
Marcela Torres - Congers NY, US
Kevin J. Pobursky - Beacon NY, US
Raymond W. Leidich - Middletown NY, US
Joan A. Windsor - Princeton NJ, US
Warren R. Mikulka - Brewster NY, US
Diana M. Ahrens - Mahopac NY, US
Ergang Shi - Ossining NY, US
Nicholas J. Papadopoulos - LaGrangeville NY, US

Assignee:

Regeneron Pharmaceuticals, inc. - Tarrytown NY

International Classification:

C12P 21/08

US Classification:

435 691, 536 235, 4353201, 435325, 435358, 435243, 43525233, 530350, 5303871, 5303873, 5303879

Abstract:

An isolated human antibody or antigen binding fragment thereof which binds to human interleukin-4 receptor alpha (hIL-4Rα) with an affinity constant (K) of less than 200 pM, as measured by surface plasmon resonance, is provided.

US Patent:

20130157313, Jun 20, 2013

Filed:

Apr 18, 2012

Appl. No.:

13/450011

Inventors:

Sean Stevens - San Francisco CA, US
Tammy T. Huang - Goldens Bridge NY, US
Joel H. Martin - Putnam Valley NY, US
Jeanette L. Fairhurst - White Plains NY, US
Ashique Rafique - Yonkers NY, US
Eric Smith - New York NY, US
Kevin J. Pobursky - Beacon NY, US
Nicholas J. Papadopoulos - Lagrangeville NY, US
James P. Fandl - Lagrangeville NY, US
Gang Chen - Yorktown Heights NY, US
Margaret Karow - Santa Rosa Valley CA, US

Assignee:

Regeneron Pharmaceuticals, Inc. - Tarrytown NY

International Classification:

C07K 16/28

US Classification:

435 696, 536 2353, 4353201, 43525233, 435334

Abstract:

A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a Kof about 500 pM or less and blocks IL-6 activity with an ICof 200 pM or less, is provided. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an affinity at least 2-fold higher relative to its binding monkey IL-6R.

US Patent:

62021966, Mar 13, 2001

Filed:

Feb 3, 1998

Appl. No.:

9/017378

Inventors:

Tammy Huang - Fremont CA
Wen-Chuan Hsu - Los Altos CA

Assignee:

LSI Logic Corporation - Milpitas CA

International Classification:

G06F 1750

US Classification:

716 14

Abstract:

A method for optimizing routing mesh segment widths within limits imposed by voltage drop and metal migration requirements, beginning with an initial mesh comprising a plurality of horizontal segments forming rows and a plurality of vertical segments forming columns. First, a voltage drop and current density associated with each segment is determined. Then a first width for each segment is found by scaling each segment width using a voltage drop scaling factor so that the routing mesh has a maximum voltage drop that satisfies the voltage drop requirement. Next, widths for each segment are determined such that the metal migration requirement minus a margin is satisfied. Then the method ensures that each segment within each row, and each segment within each column, is not more than a first scaling factor wider than its neighboring segments. A second width for each segment is found by ensuring that each segment within each row is not more than a second scaling factor wider than segments at a same vertical position in neighboring rows, and each segment within each column is not more than the second scaling factor wider than segments at a same horizontal position in neighboring columns. The method then selects the larger of the first width and second width for each segment, determines the voltage drop and current density associated with each segment, and checks whether the voltage drop and metal migration requirements are violated.

US Patent:

55683959, Oct 22, 1996

Filed:

Jun 29, 1994

Appl. No.:

8/268920

Inventors:

Tammy Huang - Fremont CA

Assignee:

LSI Logic Corporation - Milpitas CA

International Classification:

G06F 1750

US Classification:

364489

Abstract:

A system for modeling and estimating crosstalk noise and detecting false logic is provided. The noise is caused by culprit signal nets that are in a switching state and affect a victim net which is in a non-switching (DC) steady state. This estimated noise is evaluated against a predetermined threshold to determine whether any false logic results in the victim net.

US Patent:

20140255390, Sep 11, 2014

Filed:

Sep 6, 2013

Appl. No.:

14/020573

Inventors:

- Tarrytown NY, US
Sean Stevens - San Francisco CA, US
Tammy T. Huang - Goldens Bridge NY, US
Joel H. Martin - Putnam Valley NY, US
Jeanette L. Fairhurst - White Plains NY, US
Ashique Rafique - Yonkers NY, US
Eric Smith - New York NY, US
Kevin J. Pobursky - Beacon NY, US
Nicholas J. Papadopoulos - LaGrangeville NY, US
James P. Fandl - LaGrangeville NY, US
Gang Chen - Yorktown Heights NY, US
Margaret Karow - Santa Rosa Valley CA, US

Assignee:

REGENERON PHARMACEUTICALS, INC. - Tarrytown NY

International Classification:

A61K 39/395
A61K 31/519
A61K 45/06
C07K 16/24

US Classification:

4241331, 4241581

Abstract:

The present invention provides methods of preventing or treating rheumatoid arthritis using a fully human antibody or antigen-binding fragment thereof that specifically binds human interleukin-6 receptor (hIL-6R). The methods of the present invention may include administration of a second therapeutic agent, such as one or more of a non-steroidal anti-inflammatory drug (NSAID), a glucocorticoid, a disease-modifying anti-rheumatic drug (DMARD), or a TNF-alpha antagonist, T-cell blocker, anti-CD20 antibody, an IL-1, JAK or IL-17 antagonist, or any combination thereof.