Timothy A Geary

US Patent:

6632621, Oct 14, 2003

Filed:

Nov 24, 2000

Appl. No.:

09/721870

Inventors:

David E. Lowery - Portage MI
Timothy G. Geary - Kalamazoo MI
Teresa M. Kubiak - Richland MI
Martha J. Larsen - Kalamazoo MI

Assignee:

Pharmacia Upjohn Company - Kalamazoo MI

International Classification:

G01N 33569

US Classification:

435 722, 435 72, 435 721, 536 237, 530350, 5303886, 930210

Abstract:

The invention provides neuropeptide ligands, G protein-coupled receptors and methods of screening for modulators of receptor activity. Identified modulators, including neuropeptide ligand mimetics, are useful as biostatic and biocidal agents of varying scope, ranging from lethal activity restricted to particular invertebrate parasites to broad spectrum invertebrate parasiticides active on a wide range of invertebrates, including helminths and insects.

US Patent:

7208591, Apr 24, 2007

Filed:

Aug 28, 2003

Appl. No.:

10/650467

Inventors:

David E. Lowery - Portage MI, US
Timothy G. Geary - Kalamazoo MI, US
Teresa M. Kubiak - Richland MI, US
Martha J. Larsen - Kalamazoo MI, US

Assignee:

Pharmacia & Upjohn Company - Kalamazoo MI

International Classification:

C12N 15/12

US Classification:

536 235, 435 721, 435 691, 4352523, 4353201

Abstract:

The invention provides neuropeptide ligands, G protein-coupled receptors and methods of screening for modulators of receptor activity. Identified modulators, including neuropeptide ligand mimetics, are useful as biostatic and biocidal agents of varying scope, ranging from lethal activity restricted to particular invertebrate parasites to broad spectrum invertebrate parasiticides active on a wide range of invertebrates, including helminths and insects.

US Patent:

20020037863, Mar 28, 2002

Filed:

Apr 6, 2001

Appl. No.:

09/827661

Inventors:

Timothy Geary - Kalamazoo MI, US

International Classification:

A61K031/7048
A61K031/407
A61K031/365

US Classification:

514/028000, 514/409000, 514/450000

Abstract:

An anthelmintic composition comprising: (a) one or more active ingredients which is a member from the family of macrocyclic lactones; and (b) one or more active ingredients which is a member from the family of spirodioxepinoindoles is provided. The composition is used to treat or prevent parasitic diseases.

US Patent:

20040014740, Jan 22, 2004

Filed:

May 28, 2003

Appl. No.:

10/446253

Inventors:

Byung Lee - Kalamazoo MI, US
Timothy Geary - Kalamazoo MI, US
John Davis - Kalamazoo MI, US
Jerry Bowman - Lawton MI, US

International Classification:

A61K031/453
A61K031/397
C 07D 4 9/02

US Classification:

514/210190, 514/326000, 514/342000, 546/212000, 546/280400, 548/950000

Abstract:

Novel anthelmintic compositions containing thiophene derivatives as active ingredients are disclosed.

US Patent:

20040018581, Jan 29, 2004

Filed:

Jul 24, 2002

Appl. No.:

10/202348

Inventors:

Timothy Geary - Kalamazoo MI, US
Margaret Favreau - Richland MI, US

Assignee:

Pharmacia and UpJohn Company

International Classification:

C12Q001/18

US Classification:

435/032000

Abstract:

This invention describes novel methods for the identification of compounds useful as inhibitors of enzymes. The methods involve obtaining a target gene-complemented microorganism which is dependent on the expression of the target gene for survival in test conditions. By measuring the viability of the complemented microorganism after exposure to a compound, compounds that inhibit growth in test conditions are identified. These compounds that inhibit growth are further tested in conditions where the expression of the target gene is not required for growth in order to identify compounds that specifically inhibit the target gene but do not effect the viability of the host.

US Patent:

58591885, Jan 12, 1999

Filed:

May 30, 1997

Appl. No.:

8/866845

Inventors:

Timothy G. Geary - Kalamazoo MI
Jerry W. Bowman - Lawton MI
Alan R. Friedman - Portage MI

Assignee:

Pharmacia & Upjohn Company - Kalamazoo MI

International Classification:

A61K 3808

US Classification:

530329

Abstract:

The present invention provides a novel radioactive neuropeptide represented by the formula Lys-His-Glu-Tyr. sup. --I -Leu-Arg-Phe-amide. The invention also provides a method for detecting anthelmintic activity of a compound using the novel neuropeptide of the present invention in a receptor binding assay. The novel radioactive neuropeptide has potent bioactivity in Ascaris suum neuromuscular strips, and therefore is particularly useful for high volume screening for potential anthelmintic compounds.

US Patent:

50791435, Jan 7, 1992

Filed:

May 2, 1990

Appl. No.:

7/517633

Inventors:

Ronald D. Klein - Schoolcraft MI
Timothy G. Geary - Kalamazoo MI

Assignee:

The Upjohn Company - Kalamazoo MI

International Classification:

C12Q 102
C12Q 168
C12N 120
C07H 1512

US Classification:

435 29

Abstract:

A method for identifying compounds useful as antiparasitic drugs is disclosed. Deficient microorganisms are complemented with homologous metabolic enzyme genes. The metabolic enzyme is the drug target. In addition, recombinant DNA molecules comprising helminthic PFK and PEPCK genes are disclosed.