Xian Chun Huang

US Patent:

20120043203, Feb 23, 2012

Filed:

Sep 27, 2011

Appl. No.:

13/246404

Inventors:

Qiao Lin - New York NY, US
Xian Huang - New York NY, US

Assignee:

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - New York NY

International Classification:

G01N 27/333
G01N 33/66

US Classification:

20440306, 204415

Abstract:

The disclosed subject matter relates to a sensor or system for monitoring a target analyte by using a polymer solution that is capable of binding to the analyte. The sensor of the disclosed subject matter includes a viscosity-based sensor or a permittivity-based sensor. The viscosity-based sensor contains a semi-permeable membrane, a substrate, and a microchamber including a vibrational element. The permittivity-based sensor contains a semi-permeable membrane, a substrate, and a microchamber. The sensor discussed herein provides excellent reversibility and stability as highly desired for long-term analyte monitoring.

US Patent:

20130210805, Aug 15, 2013

Filed:

Oct 6, 2011

Appl. No.:

13/878654

Inventors:

Robert G. Aslanian - Rockaway NJ, US
Christopher W. Boyce - Flemington NJ, US
Brian A. McKittrick - New Vernon NJ, US
Kevin D. McCormick - Basking Ridge NJ, US
Anandan Palani - Bridgewater NJ, US
Jun Qin - Somerset NJ, US
Haiqun Tang - Belle Mead NJ, US
Dong Xiao - Warren NJ, US
Younong Yu - East Brunswick NJ, US
John P. Caldwell - Ringwood NJ, US
Elizabeth Helen Kelley - Lynnfield MA, US
Hongjun Zhang - Newton MA, US
Phieng Siliphaivanh - Newton MA, US
Rachel N. MacCoss - Oxford, GB
Joey L. Methot - Westwood MA, US
Jolicia Polivina Gauuan - Schenectady NY, US
Qin Jiang - Latham NY, US
Andrew J. Leyhane - Latham NY, US
Johny Biju - Piscataway NJ, US
Li Dong - Lawrenceville NJ, US
Xian Huang - Warren NJ, US
Ning Shao - Watchung NJ, US
Wei Zhou - Scotch Plains NJ, US
Pawan K. Dhondi - Elizabeth NJ, US

International Classification:

C07D 239/91
A61K 31/517
A61K 45/06
C07D 403/10
C07D 417/10
C07D 413/10
C07D 405/10
C07D 413/14
C07D 498/10
C07D 403/14
A61K 31/55
C07D 401/14
A61K 31/5395
C07D 471/04
C07D 401/10

US Classification:

51421207, 544284, 51426621, 5142662, 51426623, 544290, 51426624, 5142663, 544230, 540523, 514249, 544 66, 5142292, 51426622

Abstract:

This application provides for compounds of the formula Formula I or a pharmaceutically acceptable salt thereof, wherein the individual variables are defined herein, as well as processes to prepare these compounds, pharmaceutical compositions comprising the same and their use in treating disease state associated with the CRTHreceptor.

US Patent:

20160370362, Dec 22, 2016

Filed:

Jun 22, 2016

Appl. No.:

15/189372

Inventors:

- New York NY, US
Xian Huang - New York NY, US

Assignee:

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - New York NY

International Classification:

G01N 33/543
G01N 27/413
G01N 27/327
G01N 33/66
G01N 27/40

Abstract:

The disclosed subject matter relates to a sensor or system for monitoring a target analyte by using a polymer solution that is capable of binding to the analyte. The sensor of the disclosed subject matter includes a viscosity-based sensor or a permittivity-based sensor. The viscosity-based sensor contains a semi-permeable membrane, a substrate, and a microchamber including a vibrational element. The permittivity-based sensor contains a semi-permeable membrane, a substrate, and a microchamber. The sensor discussed herein provides excellent reversibility and stability as highly desired for long-term analyte monitoring.

US Patent:

20160249837, Sep 1, 2016

Filed:

May 13, 2016

Appl. No.:

15/153813

Inventors:

- New York NY, US
Xian Huang - New York NY, US

Assignee:

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - New York NY

International Classification:

A61B 5/1473
A61B 5/145

Abstract:

Techniques for monitoring a target analyte in a sample using a polymer capable of binding to the target analyte are disclosed. An implantable monitor useful for the disclosed techniques includes a microdevice coupled with a wireless interface. The wireless interface can comprise a capacitance digital converter coupled with the microdevice and can be adapted to produce a digital signal representing a measurement of the target analyte. A microcontroller can be coupled with the capacitance digital converter and a transponder can be coupled with the microcontroller to transmit the digital signal received from the capacitance digital converter to an external reader.

US Patent:

20140134607, May 15, 2014

Filed:

Jan 21, 2014

Appl. No.:

14/160092

Inventors:

- New York NY, US
Xian HUANG - New York NY, US

International Classification:

A61B 5/145
G01N 33/66
A61B 5/00
G01N 33/543

US Classification:

435 5, 422 69, 436501, 4352871, 435 724, 600365

Abstract:

Techniques for monitoring a target analyte in a sample using a polymer capable of binding to the target analyte are disclosed. A microdevice useful for the disclosed techniques includes a semi-permeable membrane structure, a substrate, a first and second microchambers formed between the membrane structure and the substrate. The first microchamber can be adapted to receive a solution including the polymer, and the second microchamber can be adapted to receive a reference solution. Environmental target analyte can permeate the semi-permeable membrane structure and enters the first microchamber and the second microchamber. Based on the difference in a property associated with the polymer solution that is responsive to the target analyte-polymer binding, and the corresponding property associated with reference solution, the presence and/or concentration of the target analyte can be determined.