Xin Xuan Jiang

US Patent:

7781421, Aug 24, 2010

Filed:

May 28, 2004

Appl. No.:

10/856314

Inventors:

Douglas F. Covey - Ballwin MO, US
Xin Jiang - Baltimore MD, US

Assignee:

Washington University - St. Louis MO

International Classification:

A61K 31/56
A61K 31/58
C07J 53/00
C07J 71/00

US Classification:

514179, 514172, 514173, 540 15, 540 76, 552510

Abstract:

Novel pentacyclic steroids and pentacyclic D-homosteroids comprising: (i) the tetracyclic steroid ring system or tetracyclic D-homosteroid ring system, respectively; (ii) a C(3) substituent selected from the group consisting of (a) a hydroxyl or carboxyl in the α-configuration and (b) a sulfate or other negatively charged moiety; and (iii) a fused fifth ring, the fused fifth ring comprising a hydrogen bond acceptor, and (a) in the case of the pentacyclic steroid the C(13) and C(17) carbons, or (b) in the case of the pentacyclic D-homosteroid the C(13) and C(17a) carbons, having utility as anesthetics and in the treatment of disorders relating to GABA function and activity.

US Patent:

20100317638, Dec 16, 2010

Filed:

Aug 20, 2010

Appl. No.:

12/860345

Inventors:

Douglas F. Covey - Ballwin MO, US
Xin Jiang - Baltimore MD, US

Assignee:

WASHINGTON UNIVERSITY - St. Louis MO

International Classification:

A61K 31/58
A61P 25/08
A61P 25/24
A61P 25/22
A61P 25/30
A61K 31/575

US Classification:

514173, 514178, 514182, 514172

Abstract:

Novel pentacyclic steroids and pentacyclic D-homosteroids comprising: (i) the tetracyclic steroid ring system or tetracyclic D-homosteroid ring system, respectively; (ii) a C(3) substituent selected from the group consisting of (a) a hydroxyl or carboxyl in the α-configuration and (b) a sulfate or other negatively charged moiety; and (iii) a fused fifth ring, the fused fifth ring comprising a hydrogen bond acceptor, and (a) in the case of the pentacyclic steroid the C(13) and C(17) carbons, or (b) in the case of the pentacyclic D-homosteroid the C(13) and C(17a) carbons, having utility as anesthetics and in the treatment of disorders relating to GABA function and activity.