Xin Zhao

US Patent:

20200055044, Feb 20, 2020

Filed:

Nov 2, 2017

Appl. No.:

16/346746

Inventors:

- Arlington MA, US
Aniruddh SARKAR - Cambridge MA, US
Xin ZHAO - Chestnut Hill MA, US
Kumaran KOLANDAIVELU - Jamaica Plain MA, US

International Classification:

B01L 3/00
G01N 33/49
G01N 27/07
G01N 27/08

Abstract:

Disclosed are methods and devices for platelet function analysis. An impedance-based micro platelet function test device comprises a pair of micro-fabricated 3D electrodes for measuring an electrical impedance between the pair electrodes during a platelet function test, and a microfluidic chamber enclosing the pair of electrodes. At least one of the electrodes comprises an electrode core coated with a metal coating, the metal coating has a patterned surface structure derived from a patterned surface of the electrode core, and the microfluidic chamber has an inlet for accepting a blood sample comprising platelets for the platelet function test. The measured electrical impedance characterizes platelet aggregation in the blood sample. Such micro platelet function test methods and devices provide a low-cost, micro electrical-mechanical system based testing platform that enable accurate and repeatable platelet function analyses.