Yi I Zhou

US Patent:

20220259644, Aug 18, 2022

Filed:

Apr 25, 2022

Appl. No.:

17/728540

Inventors:

- Hercules CA, US
Priyadarshini Gogoi - Ann Arbor MI, US
Saedeh Sepehri Javdani - Ypsilanti MI, US
Yi Zhou - Ann Arbor MI, US

International Classification:

C12Q 1/6841
G01N 33/574
C12Q 1/6844
C12Q 1/686
G01N 33/487

Abstract:

A system and method for capturing and analyzing a set of cells, comprising: an array including a set of parallel pores, each pore including a chamber including a chamber inlet and a chamber outlet, and configured to hold a single cell, and a pore channel fluidly connected to the chamber outlet; an inlet channel fluidly connected to each chamber inlet of the set of parallel pores; an outlet channel fluidly connected to each pore channel of the set of parallel pores; a set of electrophoresis channels fluidly coupled to the outlet channel, configured to receive a sieving matrix for electrophoretic separation; and a set of electrodes including a first electrode and a second electrode, wherein the set of electrodes is configured to provide an electric field that facilitates electrophoretic analysis of the set of cells.

US Patent:

20220251668, Aug 11, 2022

Filed:

Apr 25, 2022

Appl. No.:

17/728789

Inventors:

- Hercules CA, US
Priyadarshini Gogoi - Ann Arbor MI, US
Yi Zhou - Plymouth MI, US
Saedeh Sepehri - Ypsilanti MI, US
Christopher Siemer - Ypsilanti MI, US

International Classification:

C12Q 1/6886
C12Q 1/6841
G01N 33/574
B01L 3/00
C12Q 1/6834

Abstract:

A system and method for isolating cells, comprising: a substrate having a broad surface; an array comprising a set of wells defined at the broad surface of the substrate, each well including: a base surface, an open surface directly opposing the base surface, defined at the broad surface of the substrate, and configured to receive one of a single cell and a single cluster of cells from a direction perpendicular to the broad surface of the substrate, and a set of channels that fluidly couple each well to at least one adjacent well; wherein the set of wells includes an interior subset and an exterior subset fluidly coupled to and surrounding the interior subset by way of the set of channels; and a fluid delivery module surrounding the array and fluidly coupled to each well in the set of wells.

US Patent:

20210040567, Feb 11, 2021

Filed:

Oct 22, 2020

Appl. No.:

17/077095

Inventors:

- Hercules CA, US
Priyadarshini Gogoi - Ann Arbor MI, US
Yi Zhou - Plymouth MI, US
Saedeh Sepehri - Ypsilanti MI, US
Christopher Siemer - Ypsilanti MI, US

International Classification:

C12Q 1/6886
C12Q 1/6841
G01N 33/574
B01L 3/00
C12Q 1/6834

Abstract:

A system and method for isolating cells, comprising: a substrate having a broad surface; an array comprising a set of wells defined at the broad surface of the substrate, each well including: a base surface, an open surface directly opposing the base surface, defined at the broad surface of the substrate, and configured to receive one of a single cell and a single cluster of cells from a direction perpendicular to the broad surface of the substrate, and a set of channels that fluidly couple each well to at least one adjacent well; wherein the set of wells includes an interior subset and an exterior subset fluidly coupled to and surrounding the interior subset by way of the set of channels; and a fluid delivery module surrounding the array and fluidly coupled to each well in the set of wells.

US Patent:

20200410736, Dec 31, 2020

Filed:

Jun 25, 2019

Appl. No.:

16/451813

Inventors:

- San Jose CA, US
Yi Zhou - Los Angeles CA, US
Connelly Barnes - Seattle WA, US
Jimei Yang - Merced CA, US

International Classification:

G06T 13/80
G06N 3/04
G06F 17/16

Abstract:

The present disclosure relates to systems, methods, and non-transitory computer readable media for generating a digital animation of a digital animation character by utilizing a generative adversarial network and a hip motion prediction network. For example, the disclosed systems can utilize an unconditional generative adversarial network to generate a sequence of local poses of a digital animation character based on an input of a random code vector. The disclosed systems can also utilize a conditional generative adversarial network to generate a sequence of local poses based on an input of a set of keyframes. Based on the sequence of local poses, the disclosed systems can utilize a hip motion prediction network to generate a sequence of global poses based on hip velocities. In addition, the disclosed systems can generate an animation of a digital animation character based on the sequence of global poses.

US Patent:

20200115764, Apr 16, 2020

Filed:

Dec 6, 2019

Appl. No.:

16/706254

Inventors:

- Ann Arbor MI, US
Priyadarshini Gogoi - Ann Arbor MI, US
Yi Zhou - Plymouth MI, US
Saedeh Sepehri - Ypsilanti MI, US
Christopher Siemer - Ypsilanti MI, US

International Classification:

C12Q 1/6886
C12Q 1/6834
G01N 33/574
B01L 3/00
C12Q 1/6841

Abstract:

A system and method for isolating cells, comprising: a substrate having a broad surface; an array comprising a set of wells defined at the broad surface of the substrate, each well including: a base surface, an open surface directly opposing the base surface, defined at the broad surface of the substrate, and configured to receive one of a single cell and a single cluster of cells from a direction perpendicular to the broad surface of the substrate, and a set of channels that fluidly couple each well to at least one adjacent well; wherein the set of wells includes an interior subset and an exterior subset fluidly coupled to and surrounding the interior subset by way of the set of channels; and a fluid delivery module surrounding the array and fluidly coupled to each well in the set of wells.

US Patent:

20190270085, Sep 5, 2019

Filed:

May 22, 2019

Appl. No.:

16/419485

Inventors:

- Plymouth MI, US
Kyle Gleason - Brighton MI, US
Austin Payne - Ypsilanti MI, US
Priyadarshini Gogoi - Ann Arbor MI, US
Christopher Siemer - Ypsilanti MI, US
Yi Zhou - Plymouth MI, US
Saedeh Javdani Sepehri - Ypsilanti MI, US

International Classification:

B01L 3/00
G01N 35/00
B01L 7/00

Abstract:

A system for isolating cells in at least one of single-cell format and single-cluster format, comprising a reservoir, including a reservoir inlet and a reservoir outlet, configured to receive a biological sample and to receive at least one fluid, a manifold configured to receive and deliver the biological sample and the at least one fluid from the reservoir into a biological sample substrate, the manifold comprising a broad surface comprising a central region configured to receive the biological sample substrate, a set of openings configured to enable fluid flow transmission across the biological sample substrate, a manifold inlet configured to transmit flow from the reservoir the first subset of openings, a manifold outlet configured at a downstream end of the broad surface and coupled to the second subset of openings, the manifold outlet configured to transmit waste fluid from the manifold.

US Patent:

20190144931, May 16, 2019

Filed:

Jul 30, 2018

Appl. No.:

16/049057

Inventors:

- Plymouth MI, US
Priyadarshini Gogoi - Ann Arbor MI, US
Saedeh Sepehri Javdani - Ypsilanti MI, US
Yi Zhou - Ann Arbor MI, US

International Classification:

C12Q 1/6841
G01N 33/574
G01N 33/487
C12Q 1/6844
C12Q 1/686

Abstract:

A system and method for capturing and analyzing a set of cells, comprising: an array including a set of parallel pores, each pore including a chamber including a chamber inlet and a chamber outlet, and configured to hold a single cell, and a pore channel fluidly connected to the chamber outlet; an inlet channel fluidly connected to each chamber inlet of the set of parallel pores; an outlet channel fluidly connected to each pore channel of the set of parallel pores; a set of electrophoresis channels fluidly coupled to the outlet channel, configured to receive a sieving matrix for electrophoretic separation; and a set of electrodes including a first electrode and a second electrode, wherein the set of electrodes is configured to provide an electric field that facilitates electrophoretic analysis of the set of cells.

US Patent:

20180334706, Nov 22, 2018

Filed:

Jul 30, 2018

Appl. No.:

16/048975

Inventors:

- Plymouth MI, US
Priyadarshini Gogoi - Ann Arbor MI, US
Saedeh Sepehri Javdani - Ypsilanti MI, US
Yi Zhou - Ann Arbor MI, US

International Classification:

C12Q 1/6841
G01N 33/574
C12Q 1/686
G01N 33/487
C12Q 1/6844
G01N 27/447

Abstract:

A system and method for capturing and analyzing a set of cells, comprising: an array including a set of parallel pores, each pore including a chamber including a chamber inlet and a chamber outlet, and configured to hold a single cell, and a pore channel fluidly connected to the chamber outlet; an inlet channel fluidly connected to each chamber inlet of the set of parallel pores; an outlet channel fluidly connected to each pore channel of the set of parallel pores; a set of electrophoresis channels fluidly coupled to the outlet channel, configured to receive a sieving matrix for electrophoretic separation; and a set of electrodes including a first electrode and a second electrode, wherein the set of electrodes is configured to provide an electric field that facilitates electrophoretic analysis of the set of cells.