Yin Liang - Bridgewater NJ, US Jian Zhu - North Haven CT, US Laurel Sweet - Branford CT, US James Livingston - Guilford CT, US
Assignee:
Bayer Pharmaceuticals Corporation - West Haven CT
International Classification:
A61K045/00 C12N005/08
US Classification:
424/093700, 435/366000
Abstract:
The present invention relates to a method for preparing pseudo islets. In addition, the invention is also directed to methods of treating diabetes and diabetes-related disorders by administering compounds identified by the methods described herein.
Use Of Alpha-Methylglucoside (Amg) As An Indicator For Glucose Absorption And Excretion
Keith T. Demarest - Flemington NJ, US James M. Lenhard - Fort Washington PA, US Gregory C. Leo - Lansdale PA, US Yin Liang - Owings Mills MD, US Tonya L. Martin - Quakertown PA, US
Assignee:
Janssen Pharmaceutica, N.V. - Beerse
International Classification:
G01N 33/50
US Classification:
436 93
Abstract:
Presented here are methods using alpha-methylglucoside (AMG) in vivo as an indicator for glucose absorption from the gastrointestinal (GI) system or glucose excretion in the urine after oral administration of AMG. The methods find use in, for example, but not limited to, determining the effect of a sodium-dependent glucose transporter (SGLT) inhibitor in an animal, comparing the differences in the effects of a first and second SGLT inhibitor in an animal, and diagnosing a disease associated with glucose absorption from the gastrointestinal (GI) system or glucose excretion from the kidney in an animal.
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