Ying R Huang

US Patent:

6444687, Sep 3, 2002

Filed:

Dec 14, 2000

Appl. No.:

09/737141

Inventors:

Andrew W. Stamford - Chatham Township NJ
Craig D. Boyle - Branchburg NJ
Ying Huang - East Brunswick NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 314545

US Classification:

514318, 514326, 514333, 514341, 51425214, 51425309, 51425402, 51425405, 544295, 544360, 544367, 544370, 546194, 546210, 546256, 5462741

Abstract:

Compounds of the formula I or a pharmaceutically acceptable salt, solvate or N-oxide thereof, wherein X is CHâ or Nâ; Y is H, halogen, trihaloalkyl, alkyl, alkenyl, cycloalkyl, cycloalkyl, SH, âS-alkyl, or âCN. R is alkyl, âCF , cycloalkyl, heterocycloalkyl, heterocycloalkyl-alkyl, heteroarylalky or adamantyl, or optionally substituted phenyl, phenoxyalkyl, phenylthioalkyl, pyridyl, thienyl, thiazolyl, pyrazinyl, 1,2,5,6-tetrahydropyridine or âwherein R and R are hydrogen, alkyl or together form a cycloalkyl, are disclosed, as well as pharmaceutical compositions and methods of using said compounds in the treatment of eating disorders and diabetes.

US Patent:

6632828, Oct 14, 2003

Filed:

Jul 23, 2002

Appl. No.:

10/200966

Inventors:

Andrew W. Stamford - Chatham Township NJ
Craig D. Boyle - Branchburg NJ
Ying Huang - East Brunswick NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 314545

US Classification:

514333, 514341, 514326, 514318, 51425214, 51425309, 51425402, 51425405, 546194, 546210, 546256, 5462741, 544295, 544360, 544367, 544370

Abstract:

Compounds of the formula I or a pharmaceutically acceptable salt, solvate or N-oxide thereof, wherein X is CHâ or Nâ; Y is H, halogen, trihaloalkyl, alkyl, alkenyl, cycloalkyl, cycloalkyl, SH, âS-alkyl, or âCN. R is alkyl, âCF , cycloalkyl, heterocycloalkyl, heterocycloalkyl-alkyl, heteroarylalky or adamantyl, or optionally substituted phenyl, phenoxyalkyl, phenylthioalkyl, pyridyl, thienyl, thiazolyl, pyrazinyl, 1,2,5,6-tetrahydropyridine or âwherein R and R are hydrogen, alkyl or together form a cycloalkyl, are disclosed, as well as pharmaceutical compositions and methods of using said compounds in the treatment of eating disorders and diabetes.

US Patent:

6667319, Dec 23, 2003

Filed:

Jul 24, 2002

Appl. No.:

10/202239

Inventors:

Andrew W. Stamford - Chatham Township NJ
Ying Huang - East Brunswick NJ
Guoqing Li - Staten Island NY

Assignee:

Schering-Plough Corporation - Kenilworth NJ

International Classification:

A61K 314468

US Classification:

514329, 546224, 548557, 548950, 540605, 514426, 514330, 514212, 514210

Abstract:

The present invention discloses compounds which, are novel receptor antagonists for NPY Y5 as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such NPY Y5 receptor antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.

US Patent:

6707879, Mar 16, 2004

Filed:

Apr 3, 2002

Appl. No.:

10/116714

Inventors:

Keith M. McClelland - Needham MA
Craig Dawson - Shirley MA
Ying Huang - Lexington MA
Andrea L. Whitson - Jamaica Plain MA

Assignee:

L-3 Communications Security and Detection Systems - Woburn MA

International Classification:

G01N 2304

US Classification:

378 57

Abstract:

A system for remote inspection of items including at least one inspection machine constructed to examine an item under inspection to obtain information about the item, a database coupled to the at least one inspection machine that receives and stores the information about the item in an item file, the item including a unique item identifier, and an item file inspection device that receives the item file, analyzes data contained in the item file and records screening information based on an analysis of the item file. The system also includes a server that controls transfer of the item file and the screening information between the database and the item file inspection device. The screening information is linked with the item file using the unique item identifier. The item file inspection device is located remote from the at least one inspection machine.

US Patent:

6721391, Apr 13, 2004

Filed:

Apr 3, 2002

Appl. No.:

10/116718

Inventors:

Keith M. McClelland - Needham MA
Craig Dawson - Shirley MA
Ying Huang - Lexington MA
Andrea L. Whitson - Jamaica Plain MA

Assignee:

L-3 Communications Security and Detection Systems - Woburn MA

International Classification:

G01N 2310

US Classification:

378 57, 378 62

Abstract:

A computer readable medium encoded with a plurality of instructions for execution on at least one processor, the plurality of instructions performing a method of remote screening of items of baggage. The method includes steps of storing information about an item under inspection, linking a unique item identifier with the information to uniquely associate the information with the item under inspection and retrieving the information about the item under inspection in response to a request. The method also includes analyzing the information to determine a screening result for the item under inspection, and storing the screening result with the information about the item.

US Patent:

6894063, May 17, 2005

Filed:

Mar 12, 2002

Appl. No.:

10/096390

Inventors:

William J. Greenlee - Teaneck NJ, US
Ying Huang - East Brunswick NJ, US
Joseph M. Kelly - Parlin NJ, US
Stuart W. McCombie - Caldwell NJ, US
Andrew W. Stamford - Chatham Township NJ, US
Yusheng Wu - New York NY, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K031/445
A61K031/435
A61K031/41
C07D421/00
C07C281/00

US Classification:

514315, 514277, 514359, 51421001, 51421201, 546195, 564 37, 540 1, 540484, 548400

Abstract:

A novel class of compounds such as antagonists of the neuropeptide Y Y5 receptor, methods of making such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention or amelioration of one or more diseases associated with the neuropeptide Y Y5 receptor are disclosed.

US Patent:

7139406, Nov 21, 2006

Filed:

Apr 3, 2002

Appl. No.:

10/116693

Inventors:

Keith M. McClelland - Needham MA, US
Craig Dawson - Shirley MA, US
Ying Huang - Lexington MA, US
Andrea L. Whitson - Jamaica Plain MA, US

Assignee:

L-3 Communications Security and Detection Systems - Woburn MA

International Classification:

G06K 17/00
G01N 9/00
G01T 1/38

US Classification:

382100, 705 5, 340600, 378 57

Abstract:

A method of advance baggage screening includes steps of transmitting a threat file corresponding to an item under inspection to a processing center, analyzing the threat file according to a detection algorithm at the processing center to determine a screening result for the item under inspection, and transmitting the screening result to a remotely located operator interface for access by an operator.

US Patent:

7304076, Dec 4, 2007

Filed:

Oct 24, 2003

Appl. No.:

10/692559

Inventors:

Andrew W. Stamford - Chatham Township NJ, US
Ying Huang - East Brunswick NJ, US
Li Guoqing - Staten Island NY, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31/445
C07D 401/12

US Classification:

514316, 546186

Abstract:

The present invention discloses compounds which, are novel receptor antagonists for NPY Y5 as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such NPY Y5 receptor antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.