Ying Huang

US Patent:

6444687, Sep 3, 2002

Filed:

Dec 14, 2000

Appl. No.:

09/737141

Inventors:

Andrew W. Stamford - Chatham Township NJ
Craig D. Boyle - Branchburg NJ
Ying Huang - East Brunswick NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 314545

US Classification:

514318, 514326, 514333, 514341, 51425214, 51425309, 51425402, 51425405, 544295, 544360, 544367, 544370, 546194, 546210, 546256, 5462741

Abstract:

Compounds of the formula I or a pharmaceutically acceptable salt, solvate or N-oxide thereof, wherein X is CHâ or Nâ; Y is H, halogen, trihaloalkyl, alkyl, alkenyl, cycloalkyl, cycloalkyl, SH, âS-alkyl, or âCN. R is alkyl, âCF , cycloalkyl, heterocycloalkyl, heterocycloalkyl-alkyl, heteroarylalky or adamantyl, or optionally substituted phenyl, phenoxyalkyl, phenylthioalkyl, pyridyl, thienyl, thiazolyl, pyrazinyl, 1,2,5,6-tetrahydropyridine or âwherein R and R are hydrogen, alkyl or together form a cycloalkyl, are disclosed, as well as pharmaceutical compositions and methods of using said compounds in the treatment of eating disorders and diabetes.

US Patent:

6632828, Oct 14, 2003

Filed:

Jul 23, 2002

Appl. No.:

10/200966

Inventors:

Andrew W. Stamford - Chatham Township NJ
Craig D. Boyle - Branchburg NJ
Ying Huang - East Brunswick NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 314545

US Classification:

514333, 514341, 514326, 514318, 51425214, 51425309, 51425402, 51425405, 546194, 546210, 546256, 5462741, 544295, 544360, 544367, 544370

Abstract:

Compounds of the formula I or a pharmaceutically acceptable salt, solvate or N-oxide thereof, wherein X is CHâ or Nâ; Y is H, halogen, trihaloalkyl, alkyl, alkenyl, cycloalkyl, cycloalkyl, SH, âS-alkyl, or âCN. R is alkyl, âCF , cycloalkyl, heterocycloalkyl, heterocycloalkyl-alkyl, heteroarylalky or adamantyl, or optionally substituted phenyl, phenoxyalkyl, phenylthioalkyl, pyridyl, thienyl, thiazolyl, pyrazinyl, 1,2,5,6-tetrahydropyridine or âwherein R and R are hydrogen, alkyl or together form a cycloalkyl, are disclosed, as well as pharmaceutical compositions and methods of using said compounds in the treatment of eating disorders and diabetes.

US Patent:

6641708, Nov 4, 2003

Filed:

Aug 23, 1999

Appl. No.:

09/378874

Inventors:

Frederick F. Becker - Houston TX
Peter R. C. Gascoyne - Belaire TX
Ying Huang - San Diego CA
Xiao-Bo Wang - San Diego CA
Jun Yang - Houston TX

Assignee:

Board of Regents, The University of Texas System - Austin TX

International Classification:

G01N 2726

US Classification:

204547, 204643

Abstract:

Methods and apparatus for discriminating matter in a chamber having an inlet port and an outlet port utilizing dielectrophoresis and field flow fractionation. A carrier medium is introduced into the inlet port and is directed from the inlet port to the outlet port according to a velocity profile. A programmed voltage signal is applied to an electrode element coupled to the chamber to form a dielectrophoretic force on the matter. The dielectrophoretic force is balanced with a gravitational force to displace the matter to positions within said velocity profile in the carrier medium to discriminate the matter. A chamber having a top and bottom outlet port may be utilized to withdraw a first portion of a carrier medium from the top outlet port at a first, controllable fluid flow rate and to withdraw a second portion of the carrier medium from the bottom outlet port at a second, controllable fluid flow rate.

US Patent:

6667319, Dec 23, 2003

Filed:

Jul 24, 2002

Appl. No.:

10/202239

Inventors:

Andrew W. Stamford - Chatham Township NJ
Ying Huang - East Brunswick NJ
Guoqing Li - Staten Island NY

Assignee:

Schering-Plough Corporation - Kenilworth NJ

International Classification:

A61K 314468

US Classification:

514329, 546224, 548557, 548950, 540605, 514426, 514330, 514212, 514210

Abstract:

The present invention discloses compounds which, are novel receptor antagonists for NPY Y5 as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such NPY Y5 receptor antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.

US Patent:

6894063, May 17, 2005

Filed:

Mar 12, 2002

Appl. No.:

10/096390

Inventors:

William J. Greenlee - Teaneck NJ, US
Ying Huang - East Brunswick NJ, US
Joseph M. Kelly - Parlin NJ, US
Stuart W. McCombie - Caldwell NJ, US
Andrew W. Stamford - Chatham Township NJ, US
Yusheng Wu - New York NY, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K031/445
A61K031/435
A61K031/41
C07D421/00
C07C281/00

US Classification:

514315, 514277, 514359, 51421001, 51421201, 546195, 564 37, 540 1, 540484, 548400

Abstract:

A novel class of compounds such as antagonists of the neuropeptide Y Y5 receptor, methods of making such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention or amelioration of one or more diseases associated with the neuropeptide Y Y5 receptor are disclosed.

US Patent:

7304076, Dec 4, 2007

Filed:

Oct 24, 2003

Appl. No.:

10/692559

Inventors:

Andrew W. Stamford - Chatham Township NJ, US
Ying Huang - East Brunswick NJ, US
Li Guoqing - Staten Island NY, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31/445
C07D 401/12

US Classification:

514316, 546186

Abstract:

The present invention discloses compounds which, are novel receptor antagonists for NPY Y5 as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such NPY Y5 receptor antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.

US Patent:

7366706, Apr 29, 2008

Filed:

Nov 23, 2004

Appl. No.:

10/994248

Inventors:

Hung-yang (Henry) Chang - Scarsdale NY, US
Ying Huang - Yorktown Heights NY, US
Jim Alain Laredo - Katonah NY, US
Jeaha Yang - Stamford CT, US
Ray Ming Yeh - Katonah NY, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06F 17/00
G06N 5/00

US Classification:

706 45, 706 46, 706 47

Abstract:

A method for automating the deployment and lifecycle management of an integration solution by using a deployment solution template to gather deployment information, where the integration solution combines components developed separately or on different platforms. The deployment information gathered includes the computing environment topology into which the integration solution is being deployed, as well as the resource requirements and non-functional requirements of the integration solution and its components. The method provides computer implemented models for analyzing the gathered deployment information, and identifying and optimizing deployment options. Choices for selection among identified and optimized options based on non-functional requirements of the integration solution may be displayed to a user of the deployment method. The deployment template may be customized to modify the information being gathered in view of the analysis provided by the models, and in order to use the template and models in subsequent deployments and for the management of the integration solution.

US Patent:

7503032, Mar 10, 2009

Filed:

Jun 15, 2001

Appl. No.:

09/881024

Inventors:

Kumar Bhaskaran - Englewood Cliffs NJ, US
Guillermo Gallego - Ridgewood NJ, US
Ying Huang - Yorktown Heights NY, US
Ying T. Leung - Tarrytown NY, US
Nitin R. Nayak - Ossining NY, US
Sanjay E. Ramaswamy - Naperville IL, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06F 9/44

US Classification:

717104, 717105, 705 7, 705 10

Abstract:

A computer implemented system analysis and design method for use in a complex business environment characterized by a set of tightly linked business processes captures in a framework a world view of a business decision and/or a business application software system. A world view is defined by business objectives, constraints, assumptions, data, and underlying model used in business decision and/or the application software system. The framework is used to specify and document each business decision and/or business application software system in the complex environment. A BDML (Business Decision Markup Language) is used to implement the framework for specifying the world view of a business decision and/or a business application software system. A BDML processor comprises a syntax processor that checks the syntax correctness and syntax consistency within an individual and between different documents written in BDML, a logic processor that checks logical consistency between different documents written in BDML, in terms of the business objectives, constraints, assumptions, data, and underlying model among the different documents, and a knowledge-based processor including a knowledge base of business decisions, common choices for their decision support models and commercially available decision support systems, the knowledge-based processor providing suggestions for a set of BDML documents to improve consistency using the knowledge base.