Ying Jie Huang

US Patent:

6444687, Sep 3, 2002

Filed:

Dec 14, 2000

Appl. No.:

09/737141

Inventors:

Andrew W. Stamford - Chatham Township NJ
Craig D. Boyle - Branchburg NJ
Ying Huang - East Brunswick NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 314545

US Classification:

514318, 514326, 514333, 514341, 51425214, 51425309, 51425402, 51425405, 544295, 544360, 544367, 544370, 546194, 546210, 546256, 5462741

Abstract:

Compounds of the formula I or a pharmaceutically acceptable salt, solvate or N-oxide thereof, wherein X is CHâ or Nâ; Y is H, halogen, trihaloalkyl, alkyl, alkenyl, cycloalkyl, cycloalkyl, SH, âS-alkyl, or âCN. R is alkyl, âCF , cycloalkyl, heterocycloalkyl, heterocycloalkyl-alkyl, heteroarylalky or adamantyl, or optionally substituted phenyl, phenoxyalkyl, phenylthioalkyl, pyridyl, thienyl, thiazolyl, pyrazinyl, 1,2,5,6-tetrahydropyridine or âwherein R and R are hydrogen, alkyl or together form a cycloalkyl, are disclosed, as well as pharmaceutical compositions and methods of using said compounds in the treatment of eating disorders and diabetes.

US Patent:

6632828, Oct 14, 2003

Filed:

Jul 23, 2002

Appl. No.:

10/200966

Inventors:

Andrew W. Stamford - Chatham Township NJ
Craig D. Boyle - Branchburg NJ
Ying Huang - East Brunswick NJ

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 314545

US Classification:

514333, 514341, 514326, 514318, 51425214, 51425309, 51425402, 51425405, 546194, 546210, 546256, 5462741, 544295, 544360, 544367, 544370

Abstract:

Compounds of the formula I or a pharmaceutically acceptable salt, solvate or N-oxide thereof, wherein X is CHâ or Nâ; Y is H, halogen, trihaloalkyl, alkyl, alkenyl, cycloalkyl, cycloalkyl, SH, âS-alkyl, or âCN. R is alkyl, âCF , cycloalkyl, heterocycloalkyl, heterocycloalkyl-alkyl, heteroarylalky or adamantyl, or optionally substituted phenyl, phenoxyalkyl, phenylthioalkyl, pyridyl, thienyl, thiazolyl, pyrazinyl, 1,2,5,6-tetrahydropyridine or âwherein R and R are hydrogen, alkyl or together form a cycloalkyl, are disclosed, as well as pharmaceutical compositions and methods of using said compounds in the treatment of eating disorders and diabetes.

US Patent:

6667319, Dec 23, 2003

Filed:

Jul 24, 2002

Appl. No.:

10/202239

Inventors:

Andrew W. Stamford - Chatham Township NJ
Ying Huang - East Brunswick NJ
Guoqing Li - Staten Island NY

Assignee:

Schering-Plough Corporation - Kenilworth NJ

International Classification:

A61K 314468

US Classification:

514329, 546224, 548557, 548950, 540605, 514426, 514330, 514212, 514210

Abstract:

The present invention discloses compounds which, are novel receptor antagonists for NPY Y5 as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such NPY Y5 receptor antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.

US Patent:

6894063, May 17, 2005

Filed:

Mar 12, 2002

Appl. No.:

10/096390

Inventors:

William J. Greenlee - Teaneck NJ, US
Ying Huang - East Brunswick NJ, US
Joseph M. Kelly - Parlin NJ, US
Stuart W. McCombie - Caldwell NJ, US
Andrew W. Stamford - Chatham Township NJ, US
Yusheng Wu - New York NY, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K031/445
A61K031/435
A61K031/41
C07D421/00
C07C281/00

US Classification:

514315, 514277, 514359, 51421001, 51421201, 546195, 564 37, 540 1, 540484, 548400

Abstract:

A novel class of compounds such as antagonists of the neuropeptide Y Y5 receptor, methods of making such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention or amelioration of one or more diseases associated with the neuropeptide Y Y5 receptor are disclosed.

US Patent:

7304076, Dec 4, 2007

Filed:

Oct 24, 2003

Appl. No.:

10/692559

Inventors:

Andrew W. Stamford - Chatham Township NJ, US
Ying Huang - East Brunswick NJ, US
Li Guoqing - Staten Island NY, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K 31/445
C07D 401/12

US Classification:

514316, 546186

Abstract:

The present invention discloses compounds which, are novel receptor antagonists for NPY Y5 as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such NPY Y5 receptor antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.

US Patent:

7366706, Apr 29, 2008

Filed:

Nov 23, 2004

Appl. No.:

10/994248

Inventors:

Hung-yang (Henry) Chang - Scarsdale NY, US
Ying Huang - Yorktown Heights NY, US
Jim Alain Laredo - Katonah NY, US
Jeaha Yang - Stamford CT, US
Ray Ming Yeh - Katonah NY, US

Assignee:

International Business Machines Corporation - Armonk NY

International Classification:

G06F 17/00
G06N 5/00

US Classification:

706 45, 706 46, 706 47

Abstract:

A method for automating the deployment and lifecycle management of an integration solution by using a deployment solution template to gather deployment information, where the integration solution combines components developed separately or on different platforms. The deployment information gathered includes the computing environment topology into which the integration solution is being deployed, as well as the resource requirements and non-functional requirements of the integration solution and its components. The method provides computer implemented models for analyzing the gathered deployment information, and identifying and optimizing deployment options. Choices for selection among identified and optimized options based on non-functional requirements of the integration solution may be displayed to a user of the deployment method. The deployment template may be customized to modify the information being gathered in view of the analysis provided by the models, and in order to use the template and models in subsequent deployments and for the management of the integration solution.

US Patent:

7381813, Jun 3, 2008

Filed:

May 31, 2002

Appl. No.:

10/157899

Inventors:

Kathryn Rene Bracken - Morristown NJ, US
Joseph Ernest de los Angeles - Cranford NJ, US
Ying Huang - Olney MD, US
Michael Joseph Kadan - Adamstown MD, US
Gary Michael Ksander - Milford NJ, US
Dennis Bryan Zerby - Myersville MD, US

Assignee:

Novartis AG - Basel

International Classification:

C07H 21/04
C07H 21/02
C12N 15/00

US Classification:

536 235, 536 231, 536 241, 4353201

Abstract:

Mutants of steroid receptor ligand binding domains and synthetic ligands which have specific binding affinities for these receptors are provided. The use of these LBD-ligand combinations for construction of selective “molecular gene switches” is disclosed. Methods of regulating gene function using these switches are provided.

US Patent:

7408066, Aug 5, 2008

Filed:

Jun 19, 2006

Appl. No.:

11/455873

Inventors:

Robert G. Aslanian - Rockaway NJ, US
Michael Y. Berlin - Flemington NJ, US
Ying Huang - Berkeley Heights NJ, US
Kevin D. McCormick - Basking Ridge NJ, US
Mwangi W. Mutahi - Nyeri, KE
Neng-Yang Shih - Warren NJ, US
Pauline C. Ting - New Providence NJ, US
Wing C. Tom - Cedar Grove NJ, US
Junying Zheng - Bridgewater NJ, US

Assignee:

Schering Corproation - Kenilworth NJ

International Classification:

C07D 401/04
C07D 401/14
A61K 31/495

US Classification:

546184, 546192, 546193, 546194, 544224, 544336

Abstract:

Disclosed are compounds of the formula.