Ying Jiang

US Patent:

20040253647, Dec 16, 2004

Filed:

Aug 6, 2004

Appl. No.:

10/481954

Inventors:

Paul Mathews - Irvington-on-Hudson NY, US
Ralph Nixon - Tarrytown NY, US
Stephen Schmidt - Nutley NJ, US
Ying Jiang - Valhalla NY, US

International Classification:

G01N033/53
G01N033/567

US Classification:

435/007200

Abstract:

The present invention describes cell-based screening methods that allow for the elimination of false-positive results due to nonspecific toxicity of test compounds, while detecting those compounds that specifically modulate cellular metabolites in metabolic pathways associated with diseases and disorders, with particular regard to Alzheimer's disease. The methods are particularly suited to high-throughput screening techniques to identify compounds (drugs) that are effective in a cell-based system. The methods of the invention involve determining within a cell system the levels of both a metabolic precursor and a metabolite of interest and have broad application in high-throughput drug discovery and identification, particularly for precursor and metabolite molecules which are associated with disease and disease progression, such as Alzheimer's disease.

US Patent:

56266111, May 6, 1997

Filed:

Feb 10, 1994

Appl. No.:

8/194766

Inventors:

Cheng-Kung Liu - Norwalk CT
Ying Jiang - North Haven CT
Mark S. Roby - Killingworth CT
Steven L. Bennett - New Haven CT
Richard P. Stevenson - Colchester CT
Jeffrey P. Pietrangeli - Bridgeport CT

Assignee:

United States Surgical Corporation - Norwalk CT

International Classification:

A61B 1700

US Classification:

606230

Abstract:

The present invention relates to composite materials having a core portion formed from a first bioabsorbable material and at least one shell portion of a second bioabsorbable material joined to the core portion. The first and second bioabsorbable materials have different rates of bioabsorption. In a preferred embodiment, the core portion is coextruded with the shell portion to form a composite filament or sheet. The materials of the present invention may be used as sutures or formed into medical devices or surgical articles for implantation within a living organism.

US Patent:

60932007, Jul 25, 2000

Filed:

Sep 10, 1997

Appl. No.:

8/926728

Inventors:

Cheng-Kung Liu - Norwalk CT
Ying Jiang - North Haven CT
Mark S. Roby - Killingworth CT
Steven L. Bennett - Southington CT
Richard P. Stevenson - Colchester CT
Jeffrey P. Pietrangeli - Bridgeport CT

Assignee:

United States Surgical - Norwalk CT

International Classification:

A61B 1704

US Classification:

606228

Abstract:

Composite materials have a core portion formed from a biocompatible material and at least one shell portion of a biocompatible material joined to the core portion. In a preferred embodiment, the core portion is coextruded with the shell portion to form a composite filament or sheet. The composite materials may be used as sutures or formed into medical devices or surgical articles for implantation within a living organism.

US Patent:

55780466, Nov 26, 1996

Filed:

May 12, 1995

Appl. No.:

8/439830

Inventors:

Cheng-Kung Liu - Norwalk CT
Ying Jiang - North Haven CT
Mark S. Roby - Killingworth CT
Steven L. Bennett - New Haven CT
Richard P. Stevenson - Colchester CT
Jeffrey P. Pietrangeli - Bridgeport CT

Assignee:

United States Surgical Corporation - Norwalk CT

International Classification:

A61B 1700

US Classification:

606151

Abstract:

The present invention relates to composite materials having a core portion formed from a first bioabsorbable material and at least one shell portion of a second bioabsorbable material joined to the core portion. The first and second bioabsorbable materials have different rates of bioabsorption. In a preferred embodiment, the core portion is coextruded with the shell portion to form a composite filament or sheet. The materials of the present invention may be used as sutures or formed into medical devices or surgical articles for implantation within a living organism.