Ying J Jiang

US Patent:

20040253647, Dec 16, 2004

Filed:

Aug 6, 2004

Appl. No.:

10/481954

Inventors:

Paul Mathews - Irvington-on-Hudson NY, US
Ralph Nixon - Tarrytown NY, US
Stephen Schmidt - Nutley NJ, US
Ying Jiang - Valhalla NY, US

International Classification:

G01N033/53
G01N033/567

US Classification:

435/007200

Abstract:

The present invention describes cell-based screening methods that allow for the elimination of false-positive results due to nonspecific toxicity of test compounds, while detecting those compounds that specifically modulate cellular metabolites in metabolic pathways associated with diseases and disorders, with particular regard to Alzheimer's disease. The methods are particularly suited to high-throughput screening techniques to identify compounds (drugs) that are effective in a cell-based system. The methods of the invention involve determining within a cell system the levels of both a metabolic precursor and a metabolite of interest and have broad application in high-throughput drug discovery and identification, particularly for precursor and metabolite molecules which are associated with disease and disease progression, such as Alzheimer's disease.

US Patent:

20220354573, Nov 10, 2022

Filed:

May 5, 2022

Appl. No.:

17/737710

Inventors:

- Boston MA, US
Ji-Xin Cheng - Newton MA, US
Nan Zheng - Allston MA, US
Yueming Li - Brighton MA, US
Ying Jiang - Brighton MA, US
Lu Lan - Allston MA, US
Carolyn Marar - Brighton MA, US

Assignee:

Trustees of Boston University - Boston MA

International Classification:

A61B 18/18
H01P 7/08

Abstract:

A system for neuromodulation includes a split-ring resonator (SRR) comprising a resonance circuit, the SRR being implantable in a cranial target site and a source of microwave signals, wherein the microwave signals are deliverable wirelessly to couple with the SRR to produce a localized electrical field, wherein the localized electrical field inhibits one or more neurons at the cranial target site with submillimeter spatial precision.

US Patent:

20220287758, Sep 15, 2022

Filed:

Mar 9, 2022

Appl. No.:

17/690948

Inventors:

- Boston MA, US
Ji-Xin Cheng - Newton MA, US
Nan Zheng - Allston MA, US
Yueming Li - Brighton MA, US
Ying Jiang - Brighton MA, US
Lu Lan - Allston MA, US
Linli Shi - Allston MA, US

Assignee:

Trustees of Boston University - Boston MA

International Classification:

A61B 18/04
B82Y 30/00
B82Y 40/00
B01J 19/10

Abstract:

A tapered fiber optoacoustic emitter includes a nanosecond laser configured to emit laser pulses and an optic fiber. The optic fiber includes a tip configured to guide the laser pulses. The tip has a coating including a diffusion layer and a thermal expansion layer, wherein the diffusion layer includes epoxy and zinc oxide nanoparticles configured to diffuse the light while restricting localized heating. The thermal expansion layer includes carbon nanotubes (CNTs) and Polydimethylsiloxane (PDMS) configured to convert the laser pulses to generate ultrasound. The frequency of the ultrasound is tuned with a thickness of the diffusion layer and a CNT concentration of the expansion layer.