Alvin H. Schmaier - Ann Arbor MI Yongping Jiang - Northville MI
Assignee:
Temple University- of the Commonwealth System of Higher Education - Philadelphia PA
International Classification:
A61K 3817 C07K 1447
US Classification:
514 12
Abstract:
The release of bradykinin into the circulatory system is potentiated by administration of a polypeptide having an amino acid sequence corresponding to domain 3 of the human kininogen heavy chain. The polypeptide competitively inhibits the binding of high and low molecular weight kininogen to platelets and other cells which protect the kininogens from kallikrein cleavage, thereby increasing the level of bradykinin in the cirulation. The resulting in vivo effect is an intravascular elevation of bradykinin and concomitant lowering of blood pressure. The domain 3 polypeptide also inhibits thrombin-induced platelet and endothelial cell activation.
Name / Title
Company / Classification
Phones & Addresses
Yongping Jiang President
ABTEK, INC
28 Camelot Dr, Shrewsbury, MA 01545 29 Pinewood Rd, Wellesley, MA 02482