Yongping Ping Jiang

US Patent:

54729459, Dec 5, 1995

Filed:

Feb 9, 1994

Appl. No.:

8/193114

Inventors:

Alvin H. Schmaier - Ann Arbor MI
Yongping Jiang - Northville MI

Assignee:

Temple University- of the Commonwealth System of Higher Education - Philadelphia PA

International Classification:

A61K 3817
C07K 1447

US Classification:

514 12

Abstract:

The release of bradykinin into the circulatory system is potentiated by administration of a polypeptide having an amino acid sequence corresponding to domain 3 of the human kininogen heavy chain. The polypeptide competitively inhibits the binding of high and low molecular weight kininogen to platelets and other cells which protect the kininogens from kallikrein cleavage, thereby increasing the level of bradykinin in the cirulation. The resulting in vivo effect is an intravascular elevation of bradykinin and concomitant lowering of blood pressure. The domain 3 polypeptide also inhibits thrombin-induced platelet and endothelial cell activation.