Yu U Zhao

US Patent:

8362311, Jan 29, 2013

Filed:

Sep 30, 2009

Appl. No.:

12/571036

Inventors:

Richard R. Schrock - Winchester MA, US
Annie J. King - Cambridge MA, US
Yu Zhao - Brighton MA, US
Margaret M. Flook - Cambridge MA, US
Amir H. Hoveyda - Lincoln MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA
Trustees of Boston College - Chestnut Hill MA

International Classification:

C07C 6/00
C07F 11/00

US Classification:

585646, 556 63, 556413

Abstract:

The present invention relates generally to catalysts and processes for the Z-selective formation of internal olefin(s) from terminal olefin(s) via homo-metathesis reactions.

US Patent:

20090312559, Dec 17, 2009

Filed:

Jan 10, 2007

Appl. No.:

12/160411

Inventors:

Amir H. Hoveyda - Lincoln MA, US
Marc L. Snapper - Ashland MA, US
Jason Rodrigo - Brighton MA, US
Yu Zhao - Brighton MA, US

International Classification:

C07F 7/08
C07D 233/61

US Classification:

5483401, 556436, 556449

Abstract:

The present invention provides methods, compositions and systems for silylation of substrates, including direct asymmetric silylation of a substrate to provide enantiomerically enriched silylated products.

US Patent:

20230130799, Apr 27, 2023

Filed:

Sep 28, 2022

Appl. No.:

17/936059

Inventors:

- Tarrytown NY, US
Darya BURAKOV - Tarrytown NY, US
Gang CHEN - Yorktown Heights NY, US
James P. FANDL - LaGrangeville NY, US
Yu ZHAO - Williston Park NY, US

Assignee:

Regeneron Pharmaceuticals, Inc. - Tarrytown NY

International Classification:

C07K 16/46
C07K 16/00
C12N 15/90
C12N 15/85

Abstract:

This invention relates to site-specific integration and expression of recombinant proteins in eukaryotic cells. In particular, the invention includes compositions and methods for improved expression of antigen-binding proteins including monospecific and bispecific antibodies in eukaryotic cells, particularly Chinese hamster () cell lines, by employing multiple expression-enhancing locus.

US Patent:

20190233544, Aug 1, 2019

Filed:

Apr 20, 2017

Appl. No.:

16/095084

Inventors:

- Tarrytown NY, US
Darya BURAKOV - Tarrytown NY, US
Gang CHEN - Tarrytown NY, US
James P. FANDL - Tarrytown NY, US
Yu ZHAO - Tarrytown NY, US

Assignee:

REGENERON PHARMACEUTICALS, INC. - Tarrytown NY

International Classification:

C07K 16/46
C07K 16/00
C12N 15/85

Abstract:

This invention relates to site-specific integration and expression of recombinant proteins in eukaryotic cells. In particular, the invention includes compositions and methods for improved expression of antigen-binding proteins including monospecific and bispecifc antibodies in eukaryotic cells, particularly Chinese hamster () cell lines, by employing multiple expression-enhancing locus.

US Patent:

20170201347, Jul 13, 2017

Filed:

Nov 24, 2015

Appl. No.:

14/950191

Inventors:

Kapil Borle - Watertown MA, US
Biao Chen - Jamesville NY, US
Fangfang Zhu - Bridgewater NJ, US
Yu Zhao - Somerville MA, US

Assignee:

Syracuse University - Syracuse NY

International Classification:

H04L 1/00
H04L 7/04

Abstract:

A method of decoding a plurality of diverse signals for low-density parity-check (LDPC) decoders that takes advantage of signal diversity. The method allows for the combining of soft-decision LDPC encoded non-coherently modulated signals, which is in contrast to existing approaches where hard decision combining is used for non-coherently modulated signals. The method includes the steps of inputting each diversity signal into a unique demodulator, and calculating the LLR of each demodulated signal. When the diverse demodulated signals are combined into a single combined signal, each bit of the combined signal is selected according to the value of either the highest LLR value of each bit across the demodulated signals or according to the sum of the LLR of each bit across the demodulated signals.

US Patent:

20170078897, Mar 16, 2017

Filed:

Sep 14, 2016

Appl. No.:

15/264924

Inventors:

- Brookline MA, US
Georgiy Pekhteryev - Kharkiv, UA
Zhenzhen Ye - Groton MA, US
Yu Zhao - Syracuse NY, US

International Classification:

H04W 24/02
H04W 24/10

Abstract:

Devices, systems, and method for compensating for non-line-of-sight (“NLOS”) bias in time difference of arrival (“TDOA”) estimates between a first anchor and a second anchor in a network having an obstacle in the line-of-sight therebetween are provided. The systems and methods include transmitting a first packet from a first anchor; indirectly receiving the first packet by a second anchor, then transmitting a second packet by the second anchor; indirectly receiving the second packet by the first anchor; and receiving the first packet and the second packet by a mobile node. The true fly-time of the first or second packets between the first anchor and the second anchor and the bias in time of flight of the first or second packets between the first anchor and the second anchor are estimated. The time difference of arrival at the mobile device between a direct path and an indirect path is further estimated and the NLOS bias in the time difference of arrival estimated at the mobile device is corrected.