Barbara P Schick

US Patent:

7259140, Aug 21, 2007

Filed:

Mar 29, 2004

Appl. No.:

10/551005

Inventors:

James D. San Antonio - Media PA, US
Barbara P. Schick - Merion Station PA, US
Angela Verrecchio - Philadelphia PA, US

Assignee:

Thomas Jefferson University - Philadelphia PA

International Classification:

A61K 38/00

US Classification:

514 8, 530324

Abstract:

Heparin-binding peptides are provided of the formula R(XBBXBXYR)RR, R(XBBBXXBXYR)RR, and C(XBBBXXBX)C; wherein X, X, X, and Xare independently selected from the group consisting of hydropathic amino acids; B, B, B, and Bare independently selected from the group consisting of basic amino acids; C is cysteine; Yis zero or one to ten amino acid residues, wherein at least one amino acid residue is proline; n is an integer from one to ten; and R, R, and Rare independently selected segments containing from zero to twenty amino acid residues, provided, at least one of the segments R, R, and Rcomprises at least one hydrophobic amino acid residue. The peptide C(XBBBXXBX)C is optionally cyclized via a disulfide bond formed between cysteine residues. The peptides are administered to reduce plasma LMWH and heparin levels and to reduce the anticoagulant effects of heparin and LMWH. The peptides are also administered to inhibit microbial growth and to inhibit mast cell serine proteases involved in various diseases and disorders.

US Patent:

6855801, Feb 15, 2005

Filed:

Feb 2, 2000

Appl. No.:

09/496391

Inventors:

James D. San Antonio - Media PA, US
Angela Verrecchio - Brighton MA, US
Barbara P. Schick - Merion Station PA, US

Assignee:

Thomas Jefferson University - Philadelphia PA

International Classification:

C07K004/00
C07K007/06
C07K009/00

US Classification:

530300, 530328, 530329

Abstract:

The present invention involves peptides of various sequences and sizes and methods of using said peptides with a strong affinity for glycosaminoglycans and proteoglycans, wherein said peptides interact strongly with heparin, other glycosaminoglycans, or proteoglycans (PGs).