Ming J Luo

US Patent:

6447991, Sep 10, 2002

Filed:

Dec 29, 1998

Appl. No.:

09/222068

Inventors:

Charles E. Daitch - Charlottesville VA 22902
Bouvard Hosticka - Charlottesville VA 22903
Pamela N. Norris - Charlottesville VA 22901
Ming Luo - Vestavia AL 35216
Lawrence J. DeLucas - Birmingham AL 35243

International Classification:

C12Q 770

US Classification:

435 5, 435 71, 436501, 436527

Abstract:

Smart aerogel, an aerogel material doped with special bio-affinity compounds to providing means of unique collection, detection and identification of bioaerosols, including bacteria, viruses, toxins, and other bioaerosols. Aerogels, extremely low density and highly porous materials with a complex pore structure, are used as an intelligent detection material by incorporating specific bioaffinity pharmaceuticals directly into the matrix. The complex pore structure contains micropores, mesopores, and macropores in an open pore structure. The opening pore structure of the aerogel is used to create docking sites by linking high affinity pharmaceuticals that specifically bind only to certain bioaerosols. The high internal surface area of the aerogel and the extremely low density provides abundant receptor sites per unit mesopore for a high bioaerosol-receptor interaction, yet in a manner which will reduce possible damage and destruction to the bioaerosols captured.

US Patent:

6509359, Jan 21, 2003

Filed:

Mar 17, 2000

Appl. No.:

09/527189

Inventors:

Wayne J. Brouillette - Pelham AL 35124
Venkatram Reddy Atigadda - Birmingham AL 35209
Ming Luo - Vestavia Hills AL 35216
Yarlagadda S. Babu - Birmingham AL 35226

International Classification:

A61K 314418

US Classification:

514327, 51421002, 51421103, 514423, 514424, 514428, 540200, 540531, 546 24, 546221, 546243, 548413, 548541, 548543, 548551

Abstract:

A compound having the formula: wherein all variables are as defined in the specification, for use as a neuramninidase inhibitor.

US Patent:

6512100, Jan 28, 2003

Filed:

Aug 30, 2000

Appl. No.:

09/651622

Inventors:

Stephen C Johnson - Birmingham AL
Ashraf Saeed - Birmingham AL
Ming Luo - Birmingham AL

Assignee:

Ibbex, Inc. - Birmingham AL
UAB Research Foundation - Birmingham AL

International Classification:

C07H 1504

US Classification:

536 172, 536 173, 536 174, 536 177, 536 178, 536 179, 536 181, 536 184

Abstract:

The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including humans) origin. In particular, this invention provides a novel class of effective compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.

US Patent:

6812332, Nov 2, 2004

Filed:

Jan 21, 2003

Appl. No.:

10/348668

Inventors:

Stephen C. Johnson - Birmingham AL
Ashraf Saeed - Birmingham AL
Ming Luo - Birmingham AL

Assignee:

IBBEX, Inc. - Birmingham AL
UAB Research Foundation - Birmingham AL

International Classification:

C07H 1504

US Classification:

536 172, 536 173, 536 174, 536 177, 536 178, 536 179, 536 181, 536 184, 514 25, 514 23, 514 62, 435 5, 435 71, 435200

Abstract:

The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including humans) origin. In particular, this invention provides a novel class of effective compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.

US Patent:

6844346, Jan 18, 2005

Filed:

Dec 24, 2002

Appl. No.:

10/328790

Inventors:

Stephen C. Johnson - Birmingham AL, US
Ashraf Saeed - Birmingham AL, US
Ming Luo - Birmingham AL, US

Assignee:

IBBEX, Inc. - Birmingham AL
Univ. of Alabama at Birmingham - Birmingham AL

International Classification:

C07H 1504
C07H 1704

US Classification:

51425409, 514307, 514314, 514339, 514374, 514422, 514432, 514538, 424 165, 435 18, 536 172, 536 173, 536 174, 536 177, 536 178, 536 179, 536 181, 536 184

Abstract:

The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including humans) origin. These compounds are based upon N-acetylneuraminic acid glycosides. In particular, this invention provides a novel class of these compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.

US Patent:

8466177, Jun 18, 2013

Filed:

Oct 31, 2008

Appl. No.:

12/682341

Inventors:

Ming Luo - Birmingham AL, US
Zhen Yang - Ridgewood NJ, US

Assignee:

The UAB Research Foundation - Birmingham AL

International Classification:

A61K 31/4439
A61K 31/426
A61K 31/427
C07D 277/36
C07D 277/34
C07D 417/06

US Classification:

514342, 5462697, 514369, 548183

Abstract:

Compounds that are useful in treating or preventing viral infections, such as influenza, are described herein. Further described are compositions made from these compounds and methods for using the compounds and their compositions in treating or preventing viral infections.

US Patent:

20030211538, Nov 13, 2003

Filed:

Dec 3, 2002

Appl. No.:

10/309763

Inventors:

Ming Luo - Vestavia Hills AL, US

International Classification:

G01N033/53
G06F019/00
G01N033/48
G01N033/50
C07K014/47

US Classification:

435/007100, 530/350000, 702/019000

Abstract:

The present invention relates to a polypeptide that includes amino acid sequence of the CAP-Gly domain or a portion thereof and heterologous amino acid sequence, the structure of any such polypeptide and its use in designing, identifying or validating ligands to the CAP-Gly domain or homologous structure.

US Patent:

20040180393, Sep 16, 2004

Filed:

Oct 6, 2003

Appl. No.:

10/679663

Inventors:

Stephen Johnson - Birmingham AL, US
Ming Luo - Birmingham AL, US
Shijia Yan - Birmingham AL, US

International Classification:

C12Q001/48
C12Q001/34

US Classification:

435/015000, 536/053000, 435/018000

Abstract:

The current invention relates to the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including human) origin. In particular, this invention provides a novel class of effective compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.