Ying Y Luo

US Patent:

6387658, May 14, 2002

Filed:

Sep 23, 1999

Appl. No.:

09/404627

Inventors:

Ying Luo - Los Altos CA
Betty Huang - San Leandro CA

Assignee:

Rigel Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C07H 2104

US Classification:

435 691, 536 1, 536 111, 536 187, 536 221, 536 231, 536 235, 530350, 4353201

Abstract:

The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

US Patent:

6391582, May 21, 2002

Filed:

Dec 9, 1998

Appl. No.:

09/208827

Inventors:

Ying Luo - Los Altos CA
Pei Wen Yu - Burlingame CA
James Lorens - Portola Valley CA

Assignee:

Rigel Pharmaceuticlas, Inc. - So. San Francisco CA

International Classification:

C12P 2102

US Classification:

435 691, 435466, 435477, 435483

Abstract:

The invention provides shuttle vectors, and methods of using shuttle vectors, capable of expression in, at least, a mammalian cell. Furthermore, the shuttle vectors are capable of replication in at least yeast, and optionally, bacterial cells. Also provided is a method wherein yeast are transformed with a shuttle vector as provided herein. Heterologous nucleic acids flanked by 5â and 3â ends identical to a homologous recombination site within the shuttle vector are introduced to the transformed yeast and allowed to homologously recombine with the shuttle vector such that they are inserted into the vector by the yeast organism. The shuttle vector is then recovered and transferred to a mammalian cell for expression.

US Patent:

6428980, Aug 6, 2002

Filed:

Nov 16, 1999

Appl. No.:

09/441039

Inventors:

Ying Luo - Los Altos CA
PeiWen Yu - Cupertino CA
Mary Shen - Newark CA
Betty Huang - San Leandro CA

Assignee:

Rigel Pharmaceuticals, Inc. - South San Franciso CA

International Classification:

C12N 510

US Classification:

435 691, 536 231, 536 235, 435 711, 435 712, 4352523, 43525411, 4353201, 435325, 435471

Abstract:

The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

US Patent:

6562591, May 13, 2003

Filed:

Oct 21, 1999

Appl. No.:

09/425324

Inventors:

Ying Luo - Los Altos CA
C. Alan Fu - San Mateo CA
Mary Shen - Newark CA

Assignee:

Rigel Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C12P 2106

US Classification:

435 691, 4353201, 435471, 4352523, 536 235

Abstract:

The present invention is directed to polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

US Patent:

6569658, May 27, 2003

Filed:

Aug 24, 2000

Appl. No.:

09/645791

Inventors:

Ying Luo - Los Altos CA
C. Alan Fu - San Mateo CA
Mary Shen - Newark CA

Assignee:

Rigel Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C12N 912

US Classification:

435194, 424 941, 530350

Abstract:

The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

US Patent:

6589725, Jul 8, 2003

Filed:

Oct 25, 1999

Appl. No.:

09/427154

Inventors:

Ying Luo - Los Altos CA
Eva Chan - San Francisco CA
Xiang Xu - South San Francisco CA
Betty Huang - San Leandro CA

Assignee:

Rigel Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C12Q 100

US Classification:

435 4, 435 6, 435 691

Abstract:

The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

US Patent:

6617102, Sep 9, 2003

Filed:

Oct 25, 2000

Appl. No.:

09/696668

Inventors:

Ying Luo - Los Altos CA
Eva Chan - San Francisco CA
Xiang Xu - San Francisco CA
Betty Huang - San Leandro CA
Valeria Ossovskaya - Sausalito CA

Assignee:

Rigel Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

C12Q 100

US Classification:

435 4, 435 6, 435 71

Abstract:

The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

US Patent:

6623980, Sep 23, 2003

Filed:

Feb 23, 1999

Appl. No.:

09/255920

Inventors:

Joseph Fisher - San Carlos CA
James Lorens - Menlo Park CA
David Anderson - San Bruno CA
Ying Luo - Los Altos CA
Mary Shen - Newark CA

Assignee:

Rigel Pharmaceuticals, Inc. - South San Francisco CA

International Classification:

G01N 33566

US Classification:

436501, 435 691, 435325, 435357, 436518, 530300, 536 231

Abstract:

The present invention is directed to novel exocytotic polypeptides, such as Exo1 and Exo2 polypeptides and related molecules, which have an inhibitory effect on exocytosis and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are method for identifying novel compositions which mediate exocytotic polypeptide bioactivity, and the use of such compositions in diagnosis and treatment of disease.